Research and development - Articles

Pharmaceutical excipients can also be used in the manufacturing process, for example, by promoting the flowability or non-stick properties of the powder to assist in the handling of related active substances. In addition, they can also assist in vitro stability, such as preventing denaturation during the expected shelf life.
Pharmaceutical excipients are natural or synthetic substances formulated together with the active ingredients of the drug, whose purpose is to increase the formulations containing effective active ingredients or endow the active ingredients in the final dosage form with therapeutic effects, such as promoting drug absorption or solubility. Pharmaceutical excipients can also be used in the manufacturing process, for example, by promoting the flowability or non-s…

Over the course of the UK lockdown, manufacturing sectors such as pharmaceutical reaped the benefits in terms of growth. But keeping up with demand is never easy, especially amidst a global pandemic when speed of production became an ever-growing sticking point to meet the needs of scientific discovery. Having been thrust into a digital-first world, businesses in these industries have had no choice but to adapt to survive. Here, Brian Imrie, managing director of adi Facilities Engineering, evaluates how technology has played a key role within the pharmaceutical maintenance strategy, and what changes are set to make a successful stay into the future.
2020 thrust digitisation into the stratosphere across nearly every industry to speak of. With remote working and social distancing negatin…

Finland based oil refining and marketing company Neste, Oyj has entered into a pact with the South Korean chemical giant LG Chem, aiming to produce the biopolymers and biochemicals globally.
Finland based oil refining and marketing company Neste, Oyj has entered into a pact with the South Korean chemical giant LG Chem, aiming to produce the biopolymers and biochemicals globally. As per the pact, LG Chem will replace the fossil feedstocks used for manufacturing polymers and chemicals with ‘Neste Renewable Hydrocarbons’ in the near term, thereby lending its significant contribution towards transforming the world into a circular bioeconomy. Get more info : https://www.chemanalyst.com/NewsAndDeals/DealsDetails/lg-chem-and-neste-collaborate-to-produce-bio-based-polymer-resins-77 The partnership…

Solentim, the global leader for solutions to create, isolate and characterize the highest value cells for the development of new biological medicines, yesterday launched a dedicated new workflow for single cell cloning of human induced pluripotent stem cells (hiPSCs). A combination of Solentim’s VIPS™ (verified in-situ plate seeding) instrument and the new MatriClone™ matrix has been shown to give a 4 to 5-fold improvement in cloning efficiency compared with traditional limiting dilution methods.
VIPS™ + MatriClone™ combination ensures high efficiency seeding of hiPSCs with high viability Bournemouth, UK, 23rd September 2020 / Sciad Newswire / Solentim, the global leader for solutions to create, isolate and characterize the highest value cells f…

While negotiations are still ongoing, the structure of the post-Brexit medicine testing and approval process is still unclear, and the UK government has so far ruled out an extension to the transition period which is due to come to an end at the end of this year.
While negotiations are still ongoing, the structure of the post-Brexit medicine testing and approval process is still unclear, and the UK government has so far ruled out an extension to the transition period which is due to come to an end at the end of this year. What is clear is that the Medicines and Healthcare products Regulatory Agency (MHRA) is becoming independent to the EMA’s drug approval and oversight process. It might result in the testing and release of products being completed under two separate regulatory frameworks. D…

Becoming a doctor is not easy. It takes years of training and you will have to prove yourself at every turn. For those willing to put in the work, there are a number of essential steps that must be taken in order to qualify. Let’s take a look.
Becoming a doctor is not easy. It takes years of training and you will have to prove yourself at every turn. For those willing to put in the work, there are a number of essential steps that must be taken in order to qualify. Let’s take a look. University It is impossible to become a doctor without a medical degree from a GMC (General Medical Council) - approved university. Most medical degrees last for five years, and offer a mixture of medical science theory and practical training. In order to enrol, students will need at least three A levels, two of…

On behalf of the organizing committee; we invite you to join us for an exciting and stimulating meeting! The principal objective of this conference is to provide an international forum for cutting edge research in Nursing, Nursing Education and Research. A high-quality scientific program is planned, which will strike a balance between various sub-specialties in Nursing.
We are looking for Speakers and Delegates who are interested to participate at our upcoming 29th Edition of World Congress on Nursing Education & Research during May 25-26, 2020 Dublin, Ireland. Nursing Education-2020 aims to discover advances in health practice, management and education with the leading world doctors, registered nurses, health care professionals, professors, research fellows, universities, students, dir…

Anti-aging is intensively discussed nowadays. This article talks about the factors and biomarkers that relates to aging.
Exercise and aging Although lots of money and efforts have been invested into drug development, no drug is found to be effective in combatting aging. It is important to note that exercise is a truly effective anti-aging measure. In the absence of suitable treatments for age-related dysfunction, exercise is currently the only intervention that shows significant efficacy, reducing the incidence of age-related diseases, improving quality of life, and even increasing the life expectancy of the human body. Even moderate exercise can bring seeable benefits. Although key molecular participants mediating the protective effects of exercise on age-related diseases are not yet known…

Immunotherapy has proven to be effective in treating a variety of cancers. This article sorts out some of the latest research findings on cancer immunotherapy.
Cancer Res: Scientists identify potential new targets for cancer immunotherapy: GARP  According to the American Cancer Society, colorectal cancer is the third leading cause of cancer death in men and women. Although significant progress has been made in the treatment of such cancers, the 5-year survival rate of colorectal cancer patients is only 12%. Recently, in a research report published in Cancer Research, scientists from the University of South Carolina Medical University found a potential new target for colorectal cancer immunotherapy. Similar to PD-1, GARP is a special protein expressed on the surface of immune cells. R…

Alzheimer's disease is one of the most common neurodegenerative disorder for the elderly. Early-onset Alzheimer's is rare that develops before age 65, primarily genetically influenced. Generally, the patients older than age 65 who account for a large proportion among the whole patients suffer from late-onset Alzheimer’s. The patients with late-onset Alzheimer’s have to fight against a series of frustrating symptoms, such as memory loss, poor language skills, unstable emotions, and no self-care ability, which may lead to numerous troubles or burden for themselves and the family members.
Alzheimer's disease is one of the most common neurodegenerative disorder for the elderly. Early-onset Alzheimer's is rare that develops before age 65, primarily genetically influenced. Generally, the patients…

For quite a long time, it remains a puzzle as to what causes Alzheimer's disease. There are different opinions on this matter. Previously, tau and β-amyloid are to blame. In this article, let's see what new findings have been discovered.
Overactive neurons in specific regions of the brain are thought to be early disturbances of Alzheimer's disease. In a new study, researchers from the Technical University of Munich, Germany, were the first to explain the causes and mechanisms of this early neurological dysfunction. They found that the excitatory neurotransmitter glutamate persisted for too long in the vicinity of active neurons. This causes these neurons to suffer from pathological over-stimulation, which is likely to be a key factor in learning and memory loss in patients with Alzheimer'…

Small-molecule inhibitors are a well-established class of potential useful drugs. Our products are included in all kinds of fields of Medical and Pharmaceutical research, such as Neurological Disease, Cancer, Metabolic Disease and so on. This article deals with the most concerned questions about small molecule inhibitors.
In recent years, many new therapy approaches has emerged in the field of cancer treatment. The monoclonal antibody drugs approved each year is on the rise, and the immunotherapy represented by anti-PD-1/PD-L1 antibody is rewriting the pattern of cancer treatment. In addition, cell therapy, represented by CAR-T therapy, is officially on the stage, bringing a totally different treatment to blood cancer. Facing these endless stream of advanced therapies, traditional small mol…

Compared to polyclonal antibodies, monoclonal antibodies have multiple advantages, featured by strong specificity for a single epitope, little or no variability, and the easy operation to modify and customize in terms of different needs, thereby turning out to be the most suitable candidate for recombinant antibodies (rAbs). The rAbs are obtained through sequencing of the animal's immune cells and inserting the gene into a suitable cell strain, such as bacterium, yeast, and mammalian cells. Even if the original cell strain dies or is mutated, the desired cell strain can be generated by gene insertion since the antibody is definitive.
In general, polyclonal antibodies are made by collecting blood from an immunized animal stimulated with a target antigen, which can be provided all the time as…

Bispecific antibody (BsAb) is an artificially engineered antibody that can simultaneously bind two specific epitopes or target proteins with some special biological functions, such as directly targeting effector cells to tumor cells, to enhance cytotoxicity, improve antibody selectivity and functionality, and avoid immune escape mechanisms, thereby improving therapeutic efficacy. BsAb also reduces the cost of drug development and clinical trials compared to the combination of two monoclonal antibody drugs.
Bispecific antibody (BsAb) is an artificially engineered antibody that can simultaneously bind two specific epitopes or target proteins with some special biological functions, such as directly targeting effector cells to tumor cells, to enhance cytotoxicity, improve antibody selectivity a…

Enzymes, as a biologically active catalyst, also have some special properties compared to other industrial catalysts. Understanding these characteristics is of great significance for us to understand enzymes, and better utilize enzymes for industrial use and production.
Cellular activity carrying out in the living body depends on different chemical reactions. If there is no enzyme, then the body's metabolism and other life-related reactions can only be carried out at an extremely slow rate. Under such circumstances, life activities cannot be maintained. Scientists predict that if there is no enzyme, the body temperature needs to reach about 300 °C to digest food.   The human body may lack certain enzymes for some reasons, causing the reaction catalyzed by the enzyme to be abnormal, and…

More than 2,000 enzymes have been identified, and each enzyme is involved with one specific chemical reaction. Enzymes are therefore substrate-specific. They are grouped into a half-dozen classes on the basis of the kinds of reactions they take part in.
Enzymes are key protein molecules in living systems. Once synthesized, they are not usually converted to other kinds of molecules, and so are the substances taken in as fuel for digestive and respiratory processes (such as sugar, fat, and molecular oxygen). This is because enzymes are catalysts, which means they can participate in chemical reactions without themselves being changed, just like the moderator of a public debate who ideally moves the participants and the audience toward a conclusion by dictating the terms of the argument while n…

Here are the top Pharma and Life Science recruitment organisations advertising in September on PharmiWeb.jobs.
Barrington James Clinical - 206 Jobs RBW Consulting - 163 Jobs i-Pharm Consulting - 141 Jobs CHASE - 133 Jobs SEC Recruitment - 116 Jobs ID Search & Selection - 86 Jobs Clinical Professionals Ltd - 85 Jobs Hobson Prior - 76 Jobs CK Clinical - 68 Jobs Barrington James Europe - 63 Jobs X4 Life Sciences - 63 Jobs Advanced Regulatory (UK & Europe) - 60 Jobs Barrington James Medical / Executive - 58 Jobs Thornshaw Recruitment - 56 Jobs Barrington James Scientific - 48 Jobs Only Medics Recruitment ltd - 46 Jobs Planet Pharma Staffing Limited - 45 Jobs Umbilical Life - 44 Jobs ProClinical Ltd - 39 Jobs CTC Resourcing Solutions - 34 Jobs Volt - 31 Jobs Haybury - 31 Jobs Advanced S…

A list of the TOP Pharma Companies who are hiring this month (September)
Covance - 388 Jobs BSI Group - 167 Jobs PRA Health Sciences - 105 Jobs PPD- 81 Jobs Roche - 77 Jobs Synteract- 74 Jobs United BioSource Corporation. - 69 Jobs Cytel - 68 Jobs Syneos Health - 52 Jobs CROMSOURCE - 51 Jobs IQVIA - 36 Jobs AstraZeneca - 36 Jobs Celgene - 32 Jobs IQVIA Biotech - 21 Jobs Oxford BioMedica (UK) Limited - 16 Jobs Lonza - 16 Jobs Grunenthal GmbH - 14 Jobs   Register and Upload Your CV Now

Translational science and research organisation, Fera Science Ltd, has hosted its Advances in Environmental Risk Assessments symposium, inviting members of the PPP industry to come together and discuss how to develop new solutions that will support an increase in agricultural outputs.
Plant protection products (PPPs) used in agriculture have doubled in numbers since the 1980s. Without them, the food safety of billions of people would be threatened. But the PPP chemical industry continues to face ongoing debate to ensure that these products raise the quality and yield crops with minimal impact on the surrounding environment. To help facilitate this debate, Translational science and research organisation, Fera Science Ltd, has hosted its Advances in Environmental Risk Assessments symposium…

From driverless cars being rolled out recently to robots performing surgeries, technology has surely made a stellar progress. One such example is medical robots. Medical robots are set to revolutionize the healthcare sector, especially surgeries, since they are becoming more and more acceptable, globally. They not only help in reducing the time of surgery but also ensure the accuracy of the whole process coupled with better quality of patient care, thereby increasing the demand for surgical robots across the globe.
The growth of the Medical Robots Market can be attributed to the issuance of IPOs by medical robot companies, advantages offered by robot-assisted training in rehabilitation therapy, growing hospital investments in medical robots, increasing funding for medical robot research, an…