Research and development - Articles
A new edition of the EPO Guidelines for Examination (‘the guidelines’) came into force on 1 March 2021. Relevant to life sciences, this edition includes a new subsection detailing EPO practice with respect to the interpretation of terms relating to amino or nucleic acid sequences, as well as a new section on the examination of claims to antibodies.
A new edition of the EPO Guidelines for Examination (‘the guidelines’) came into force on 1 March 2021. Relevant to life sciences, this edition includes a new subsection detailing EPO practice with respect to the interpretation of terms relating to amino or nucleic acid sequences, as well as a new section on the examination of claims to antibodies. Terms in relation to amino or nucleic acid sequences (F-IV, 4.24) In the field of biotechnology, cl…
A new edition of the EPO Guidelines for Examination (‘the guidelines’) came into force on 1 March 2021. Relevant to life sciences, this edition includes a new subsection detailing EPO practice with respect to the interpretation of terms relating to amino or nucleic acid sequences, as well as a new section on the examination of claims to antibodies. Terms in relation to amino or nucleic acid sequences (F-IV, 4.24) In the field of biotechnology, cl…
07-Apr-2021
Pharmacovigilance has developed inconceivably overall of late, and its significance when in doubt and in a general sense in the clinical thought industry has been seen. To frustrate or chop down quiet dangers, Pharmacovigilance is crucial.
Pharmacovigilance is a wide term to depict drug success. It portrays the course of action, flourishing, assessment, assumption, and checking of the malignant impacts of solutions and meds. It is a cycle driven and reliable area inside the prescription business. It is the security assessment of showed drugs separated under pragmatic or interminable states of clinical use in enormous associations. Pharmacovigilance intends to perceive dim security issues as right on time as could be viewed as average. It also plans to perceive an improvement in the rehash o…
Pharmacovigilance is a wide term to depict drug success. It portrays the course of action, flourishing, assessment, assumption, and checking of the malignant impacts of solutions and meds. It is a cycle driven and reliable area inside the prescription business. It is the security assessment of showed drugs separated under pragmatic or interminable states of clinical use in enormous associations. Pharmacovigilance intends to perceive dim security issues as right on time as could be viewed as average. It also plans to perceive an improvement in the rehash o…
In the month of Brake’s 'Road Safety Week 2019', Dr Jim Golby, Director of Research and Customer Experience for Applied Driving Techniques (ADT) highlights the benefits of addressing the business-critical activity of driving for work. Most organisations have employees that are required to drive for work as either a primary or secondary function of their job. This necessary task exposes employees to what is considered the most high-risk activity typically undertaken by employees: driving at work.
Most organisations have employees that are required to drive for work as either a primary or secondary function of their job. This necessary task exposes employees to what is considered the most high-risk activity typically undertaken by employees: driving at work. Driving on company business, or wo…
Most organisations have employees that are required to drive for work as either a primary or secondary function of their job. This necessary task exposes employees to what is considered the most high-risk activity typically undertaken by employees: driving at work. Driving on company business, or wo…
Preclinical examinations encompass various activities that fill in as an association between drug disclosure and status and the initiation of a clinical primer on individuals.
Surely, even before a medicine could be attempted in a clinical fundamental, the improvement collaboration of a drug all around incorporates three critical advances, including divulgence, preclinical unforeseen development, and a while later clinical starter. The advancement from exposure to preclinical improvement is a persistent association. The results got from toxicology and preliminary pharmacology testing regularly add to contender decision for a prescription. The recording of an Investigational New Drug (IND) sets up a breaking point between preclinical new development and clinical research of a medicine. The c…
Surely, even before a medicine could be attempted in a clinical fundamental, the improvement collaboration of a drug all around incorporates three critical advances, including divulgence, preclinical unforeseen development, and a while later clinical starter. The advancement from exposure to preclinical improvement is a persistent association. The results got from toxicology and preliminary pharmacology testing regularly add to contender decision for a prescription. The recording of an Investigational New Drug (IND) sets up a breaking point between preclinical new development and clinical research of a medicine. The c…
Excipients are very important for pharmaceutical preparations. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more convenient to use.
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more convenient to use. Divided doses are easier to be accepted by the body. However, in addition to the above-mentioned effects, excipients of the drug are also one of the important facto…
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more convenient to use. Divided doses are easier to be accepted by the body. However, in addition to the above-mentioned effects, excipients of the drug are also one of the important facto…
25-Mar-2021
According to process and intrinsic quality, plant extracts can be divided into simple extracts, quantitative extracts, standardized extracts, and purified extracts.
Plant extract refers to a product that is formed through an extraction and separation process where plants are used as raw materials. Generally the original components of the plants are not changed. In some cases, excipients are also used to make the powder or granular products have features like good fluidity and resistance to moisture absorption. There are also a small amount of liquid or oily plant extract products. According to process and intrinsic quality, plant extracts can be divided into simple extracts, quantitative extracts, standardized extracts, and purified extracts. Based on the product form, they are classified i…
Plant extract refers to a product that is formed through an extraction and separation process where plants are used as raw materials. Generally the original components of the plants are not changed. In some cases, excipients are also used to make the powder or granular products have features like good fluidity and resistance to moisture absorption. There are also a small amount of liquid or oily plant extract products. According to process and intrinsic quality, plant extracts can be divided into simple extracts, quantitative extracts, standardized extracts, and purified extracts. Based on the product form, they are classified i…
24-Mar-2021
Every clinical trial chooses the best clinical research course of action to collect as much data as possible. Before any of these medications reach the patients, it has to undergo our clinical trial phases.
Clinical trials are studies performed for research in people who have an objective at evaluating a surgical, medical, or behavioral intervention. Clinical Trials are the primary method of researchers to determine whether a new treatment or drug, or diet is safe and effective in human beings. Clinical research requires trials conducted to collect information regarding the efficiency and safety of a new drug, device, or treatment. These are tested on certain individuals, and this process is termed clinical trial recruitment. The main aim of patient recruitment is to raise awa…
Clinical trials are studies performed for research in people who have an objective at evaluating a surgical, medical, or behavioral intervention. Clinical Trials are the primary method of researchers to determine whether a new treatment or drug, or diet is safe and effective in human beings. Clinical research requires trials conducted to collect information regarding the efficiency and safety of a new drug, device, or treatment. These are tested on certain individuals, and this process is termed clinical trial recruitment. The main aim of patient recruitment is to raise awa…
Ionic liquids, as an exciting class of compounds that can circumvent the above problems, are being ignored. Half of the drugs currently on the market are salts linked together by ionic bonds.
In drug development and production, solid active pharmaceutical ingredients, which are usually made into powders or tablets, are a preferred choice compared with liquid active pharmaceutical ingredients. If solid active ingredients are to be finally marketed, the issue of solubility must be solved. 40-70% of drug development failures are due to poor solubility. This is because drugs of poor solubility cannot be well-absorbed by the body. Ionic liquids, as an exciting class of compounds that can circumvent the above problems, are being ignored. Half of the drugs currently on the…
In drug development and production, solid active pharmaceutical ingredients, which are usually made into powders or tablets, are a preferred choice compared with liquid active pharmaceutical ingredients. If solid active ingredients are to be finally marketed, the issue of solubility must be solved. 40-70% of drug development failures are due to poor solubility. This is because drugs of poor solubility cannot be well-absorbed by the body. Ionic liquids, as an exciting class of compounds that can circumvent the above problems, are being ignored. Half of the drugs currently on the…
24-Mar-2021
Excipients are the general term for other materials in preparations except for the main drug, and are an important part of pharmaceutical preparations.
The purpose of formulation development is to ensure that the drug is safe, effective, stable, and convenient to use. If the dosage form is improperly selected and if the prescription and process design are unreasonable, it will have a certain impact on the quality of the drug product, and even affect the drug’s efficacy and safety. Therefore, formulation research occupies a very important position in drug development. Excipients are the general term for other materials in preparations except for the main drug, and are an important part of pharmaceutical preparations. Below are a few guidelines for the selection of excipients in drug formulat…
The purpose of formulation development is to ensure that the drug is safe, effective, stable, and convenient to use. If the dosage form is improperly selected and if the prescription and process design are unreasonable, it will have a certain impact on the quality of the drug product, and even affect the drug’s efficacy and safety. Therefore, formulation research occupies a very important position in drug development. Excipients are the general term for other materials in preparations except for the main drug, and are an important part of pharmaceutical preparations. Below are a few guidelines for the selection of excipients in drug formulat…
According to a new cardiac surgery market study by iData Research, the number of cardiac surgeries exceeds 900,000 procedures each year in the United States. The US Cardiac surgery market is growing rapidly driven by the growth of many underlying procedures.
The number of cardiac surgery procedures commonly includes: • Coronary Artery Bypass Grafting (CABG)• Transcatheter Aortic Valve Replacements (TAVR)• Surgical Heart Valve Replacements• Annuloplasty Repairs• Transcatheter Mitral Valve Repairs (TMVR)• Balloon Valvuloplasties• Transmyocardial Revascularizations• Intra-Aortic Balloon Counterpulsation• Donor Heart Transplants TOP CARDIAC SURGERIES In the US cardiac surgery market, the largest portion of the procedures comes from coronary artery bypass graft (CABG) procedures. Desp…
The number of cardiac surgery procedures commonly includes: • Coronary Artery Bypass Grafting (CABG)• Transcatheter Aortic Valve Replacements (TAVR)• Surgical Heart Valve Replacements• Annuloplasty Repairs• Transcatheter Mitral Valve Repairs (TMVR)• Balloon Valvuloplasties• Transmyocardial Revascularizations• Intra-Aortic Balloon Counterpulsation• Donor Heart Transplants TOP CARDIAC SURGERIES In the US cardiac surgery market, the largest portion of the procedures comes from coronary artery bypass graft (CABG) procedures. Desp…
According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have an impact on the expression of genes regulating cholesterol metabolism, among other things. The findings provide valuable new insight into the genetics of coronary artery disease.
According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have an impact on the expression of genes regulating cholesterol metabolism, among other things. The findings provide valuable new insight into the genetics…
According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have an impact on the expression of genes regulating cholesterol metabolism, among other things. The findings provide valuable new insight into the genetics…
The U.S. Food and Drug Administration recently granted marketing authorization for an anterior cruciate ligament (ACL) implant, intended to perform as an alternative to traditional ACL reconstructions. The Bridge-Enhanced ACL Repair (BEAR) Implant, by Miach Orthopaedics, differs from the traditional surgical reconstruction as it does not require the use of harvested tendons for ACL repair but rather helps the tendon to rebuild itself.
The U.S. Food and Drug Administration recently granted marketing authorization for an anterior cruciate ligament (ACL) implant, intended to perform as an alternative to traditional ACL reconstructions. The Bridge-Enhanced ACL Repair (BEAR) Implant, by Miach Orthopaedics, differs from the traditional surgical reconstruction as it does not require the use of har…
The U.S. Food and Drug Administration recently granted marketing authorization for an anterior cruciate ligament (ACL) implant, intended to perform as an alternative to traditional ACL reconstructions. The Bridge-Enhanced ACL Repair (BEAR) Implant, by Miach Orthopaedics, differs from the traditional surgical reconstruction as it does not require the use of har…
AI uses colorful, time-lapse heat maps to identify the features of embryos that could result in more successful implants and develop into a pregnancy.
Although in vitro fertilization solely involves a sperm and an egg, the process leading to an embryo can be more challenging than just putting the two together. In 2019, the Centers for Disease Control and Prevention (CDC) reported that approximately 10% of women in the U.S. between the ages of 15-44 had difficulty either getting pregnant or avoiding a miscarriage. This demographic of women suffering from ovulation disorders directly translates into a potential patient population for assisted reproduction procedures. According to one Israeli machine learning startup, AI has the potential to boost the success rate of in vitro fertilization (IV…
Although in vitro fertilization solely involves a sperm and an egg, the process leading to an embryo can be more challenging than just putting the two together. In 2019, the Centers for Disease Control and Prevention (CDC) reported that approximately 10% of women in the U.S. between the ages of 15-44 had difficulty either getting pregnant or avoiding a miscarriage. This demographic of women suffering from ovulation disorders directly translates into a potential patient population for assisted reproduction procedures. According to one Israeli machine learning startup, AI has the potential to boost the success rate of in vitro fertilization (IV…
05-Feb-2021
The duration and efficacy of the clinical trials for COVID-19 vaccine are the most considerable factors for the inventors. These two factors are focused based on statistical decisions. The statistical decisions are very helpful for the pharmaceuticals to get their roles quickly and more effectively. The following statistical areas played an important role in getting the COVID-19 vaccine trails quick and effective.
After all the tensions and confusion, mankind conquered COVID-19 disease through the development of effective vaccine. When you are going through the development history of vaccines, you will come across these terms; ITT Analysis, Toxicity Monitoring, Interim analysis, Immunogenicity, noninferiority, Vaccine efficacy, etc. Yes, these terms are relevant in a novel vaccine developme…
After all the tensions and confusion, mankind conquered COVID-19 disease through the development of effective vaccine. When you are going through the development history of vaccines, you will come across these terms; ITT Analysis, Toxicity Monitoring, Interim analysis, Immunogenicity, noninferiority, Vaccine efficacy, etc. Yes, these terms are relevant in a novel vaccine developme…
Pharmaceutical excipients can also be used in the manufacturing process, for example, by promoting the flowability or non-stick properties of the powder to assist in the handling of related active substances. In addition, they can also assist in vitro stability, such as preventing denaturation during the expected shelf life. The choice of suitable excipients also depends on the route of administration and dosage form, as well as the active ingredient and other factors.
Pharmaceutical excipients are natural or synthetic substances formulated together with the active ingredients of the drug, whose purpose is to increase the formulations containing effective active ingredients or endow the active ingredients in the final dosage form with therapeutic effects, such as promoting drug absorpt…
Pharmaceutical excipients are natural or synthetic substances formulated together with the active ingredients of the drug, whose purpose is to increase the formulations containing effective active ingredients or endow the active ingredients in the final dosage form with therapeutic effects, such as promoting drug absorpt…
Pharmaceutical excipients can also be used in the manufacturing process, for example, by promoting the flowability or non-stick properties of the powder to assist in the handling of related active substances. In addition, they can also assist in vitro stability, such as preventing denaturation during the expected shelf life.
Pharmaceutical excipients are natural or synthetic substances formulated together with the active ingredients of the drug, whose purpose is to increase the formulations containing effective active ingredients or endow the active ingredients in the final dosage form with therapeutic effects, such as promoting drug absorption or solubility. Pharmaceutical excipients can also be used in the manufacturing process, for example, by promoting the flowability or non-s…
Pharmaceutical excipients are natural or synthetic substances formulated together with the active ingredients of the drug, whose purpose is to increase the formulations containing effective active ingredients or endow the active ingredients in the final dosage form with therapeutic effects, such as promoting drug absorption or solubility. Pharmaceutical excipients can also be used in the manufacturing process, for example, by promoting the flowability or non-s…
Over the course of the UK lockdown, manufacturing sectors such as pharmaceutical reaped the benefits in terms of growth. But keeping up with demand is never easy, especially amidst a global pandemic when speed of production became an ever-growing sticking point to meet the needs of scientific discovery.
Having been thrust into a digital-first world, businesses in these industries have had no choice but to adapt to survive. Here, Brian Imrie, managing director of adi Facilities Engineering, evaluates how technology has played a key role within the pharmaceutical maintenance strategy, and what changes are set to make a successful stay into the future.
2020 thrust digitisation into the stratosphere across nearly every industry to speak of. With remote working and social distancing negatin…
2020 thrust digitisation into the stratosphere across nearly every industry to speak of. With remote working and social distancing negatin…
Finland based oil refining and marketing company Neste, Oyj has entered into a pact with the South Korean chemical giant LG Chem, aiming to produce the biopolymers and biochemicals globally.
Finland based oil refining and marketing company Neste, Oyj has entered into a pact with the South Korean chemical giant LG Chem, aiming to produce the biopolymers and biochemicals globally. As per the pact, LG Chem will replace the fossil feedstocks used for manufacturing polymers and chemicals with ‘Neste Renewable Hydrocarbons’ in the near term, thereby lending its significant contribution towards transforming the world into a circular bioeconomy. Get more info : https://www.chemanalyst.com/NewsAndDeals/DealsDetails/lg-chem-and-neste-collaborate-to-produce-bio-based-polymer-resins-77 The partnership…
Finland based oil refining and marketing company Neste, Oyj has entered into a pact with the South Korean chemical giant LG Chem, aiming to produce the biopolymers and biochemicals globally. As per the pact, LG Chem will replace the fossil feedstocks used for manufacturing polymers and chemicals with ‘Neste Renewable Hydrocarbons’ in the near term, thereby lending its significant contribution towards transforming the world into a circular bioeconomy. Get more info : https://www.chemanalyst.com/NewsAndDeals/DealsDetails/lg-chem-and-neste-collaborate-to-produce-bio-based-polymer-resins-77 The partnership…
Solentim, the global leader for solutions to create, isolate and characterize the highest value cells for the development of new biological medicines, yesterday launched a dedicated new workflow for single cell cloning of human induced pluripotent stem cells (hiPSCs). A combination of Solentim’s VIPS™ (verified in-situ plate seeding) instrument and the new MatriClone™ matrix has been shown to give a 4 to 5-fold improvement in cloning efficiency compared with traditional limiting dilution methods.
VIPS™ + MatriClone™ combination ensures high efficiency seeding of hiPSCs with high viability Bournemouth, UK, 23rd September 2020 / Sciad Newswire / Solentim, the global leader for solutions to create, isolate and characterize the highest value cells f…
VIPS™ + MatriClone™ combination ensures high efficiency seeding of hiPSCs with high viability Bournemouth, UK, 23rd September 2020 / Sciad Newswire / Solentim, the global leader for solutions to create, isolate and characterize the highest value cells f…
19-Mar-2021
While negotiations are still ongoing, the structure of the post-Brexit medicine testing and approval process is still unclear, and the UK government has so far ruled out an extension to the transition period which is due to come to an end at the end of this year.
While negotiations are still ongoing, the structure of the post-Brexit medicine testing and approval process is still unclear, and the UK government has so far ruled out an extension to the transition period which is due to come to an end at the end of this year. What is clear is that the Medicines and Healthcare products Regulatory Agency (MHRA) is becoming independent to the EMA’s drug approval and oversight process. It might result in the testing and release of products being completed under two separate regulatory frameworks. D…
While negotiations are still ongoing, the structure of the post-Brexit medicine testing and approval process is still unclear, and the UK government has so far ruled out an extension to the transition period which is due to come to an end at the end of this year. What is clear is that the Medicines and Healthcare products Regulatory Agency (MHRA) is becoming independent to the EMA’s drug approval and oversight process. It might result in the testing and release of products being completed under two separate regulatory frameworks. D…
