Research and development - Articles
They may have been developed to better manage fluids on production lines, but transparent pressure vessels are increasingly being seen as ideal testing environments for research and development. With orders from blue chip companies including Apple research organisations like Boston Scientific and major universities, engineer Loris Medart from SR-TEK discusses how vessels designed for use in industry are revolutionising R&D.
Fluids have long been seen as one of the most difficult substances to manage on a production line. Movement, pressure, temperature, and humidity are just a few of the factors that can drastically alter fluid performance. As a result, when creating the world’s only commercially available transparent pressure vessel we had to ensure it enabled complete control of the inter…
Fluids have long been seen as one of the most difficult substances to manage on a production line. Movement, pressure, temperature, and humidity are just a few of the factors that can drastically alter fluid performance. As a result, when creating the world’s only commercially available transparent pressure vessel we had to ensure it enabled complete control of the inter…
Leukemia cell lines are important and widely used research tools. Their usefulness is mainly connected with their ability to provide an indefinite source of biological material for experimental purposes. Due to their high relevance for human disease, easy manipulation, and relative low costs, leukemia cell lines continue to represent vital in vitro model systems for a large range of ongoing investigations, especially basic leukemia research and drug discovery.
Leukemia cell lines are important and widely used research tools. Their usefulness is mainly connected with their ability to provide an indefinite source of biological material for experimental purposes. Due to their high relevance for human disease, easy manipulation, and relative low costs, leukemia cell lines continu…
Leukemia cell lines are important and widely used research tools. Their usefulness is mainly connected with their ability to provide an indefinite source of biological material for experimental purposes. Due to their high relevance for human disease, easy manipulation, and relative low costs, leukemia cell lines continu…
Human primary cardiomyocyte-based models are superior to whether artificial cellular models or animal models due to their native physiological and pharmacological properties. Therefore, human primary cardiomyocytes have the potential to become the most clinically relevant model for developing novel cardiac drugs and predicting safety assessment of new drugs.
What are Human Cardiomyocytes? The heart is one of the first organs formed in the embryo, which highlights its crucial function in pumping blood to carry oxygen and nutrients to other tissues of the organism whether during development or in later life. Human primordial heart starts to beat at around 22 days after fertilization. It is the presence of cardiomyocytes that results in the early beating of the heart. Cardiomyocytes,…
What are Human Cardiomyocytes? The heart is one of the first organs formed in the embryo, which highlights its crucial function in pumping blood to carry oxygen and nutrients to other tissues of the organism whether during development or in later life. Human primordial heart starts to beat at around 22 days after fertilization. It is the presence of cardiomyocytes that results in the early beating of the heart. Cardiomyocytes,…
27-Aug-2021
Animal primary cells are isolated directly from healthy or diseased tissue via an enzymatic, chemical, or mechanical process. These cells can be taken from the animal’s kidney, liver, skin, or another organ. Once removed from the in vivo environment, these cells are then placed in an artificial (in vitro) environment for propagation.
Animal Primary Cells Animal primary cells are isolated directly from healthy or diseased tissue via an enzymatic, chemical, or mechanical process. These cells can be taken from the animal’s kidney, liver, skin, or another organ. Once removed from the in vivo environment, these cells are then placed in an artificial (in vitro) environment for propagation. When in an in vitro environment, animal cells must be carefully cultured. This includes ensu…
Animal Primary Cells Animal primary cells are isolated directly from healthy or diseased tissue via an enzymatic, chemical, or mechanical process. These cells can be taken from the animal’s kidney, liver, skin, or another organ. Once removed from the in vivo environment, these cells are then placed in an artificial (in vitro) environment for propagation. When in an in vitro environment, animal cells must be carefully cultured. This includes ensu…
27-Aug-2021
Stem cells are primitive, undifferentiated cells that can potentially turn into a wide variety of cell types. Liver cells, blood cells, and muscle cells are only a few of the specialized types that have their origin in stem cells. Aside from their ability to differentiate into cells with specific functions, they can also divide or renew themselves indefinitely.
Stem cells are primitive, undifferentiated cells that can potentially turn into a wide variety of cell types. Liver cells, blood cells, and muscle cells are only a few of the specialized types that have their origin in stem cells. Aside from their ability to differentiate into cells with specific functions, they can also divide or renew themselves indefinitely. Because they can repair and regenerate damaged tissue…
Stem cells are primitive, undifferentiated cells that can potentially turn into a wide variety of cell types. Liver cells, blood cells, and muscle cells are only a few of the specialized types that have their origin in stem cells. Aside from their ability to differentiate into cells with specific functions, they can also divide or renew themselves indefinitely. Because they can repair and regenerate damaged tissue…
BM-MNCs, the heterogeneous cell mixture, are widely used in cell-based therapy and regenerative medicine, which can promote distinct angiogenic properties, mediate vascular repair, express several cytoprotective growth factors and cytokines and restore pathologically altered genes after ischemic injury. BM-MNCs can be prepared rapidly within a few hours and be collected autologously just prior to administration, which could be advantageous in acute clinical care settings, compared with other cell sources, such as stem cells requiring a period of cell culture before transplantation.
Cell therapy has been identified as an effective method to regenerate damaged tissue. Bone marrow-derived mononuclear cells (BM-MNCs) were first reported on a therapeutic angiogenesis for…
Cell therapy has been identified as an effective method to regenerate damaged tissue. Bone marrow-derived mononuclear cells (BM-MNCs) were first reported on a therapeutic angiogenesis for…
27-Aug-2021
The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value.
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value. However, there are some technical difficulties that hinder the development of children's oral liquid preparations. Poor solubil…
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value. However, there are some technical difficulties that hinder the development of children's oral liquid preparations. Poor solubil…
20-Aug-2021
With the increasing supply of good quality fresh and cryo-preserved human hepatocytes (such as ABC-TC3646, AcceGen advanced technology), researchers can further apply this in vitro model to advance our knowledge of liver functions, the mechanisms underlying the regulation and drug-induced changes of metabolic enzyme expression and hepatocellular integrity.
Hepatocytes are parenchymal cells that constitute as much as 80% of the total liver volume and mediate a number of vital liver functions, such as the control of lipid and carbohydrate homeostasis, the synthesis of various proteins, the storage of vitamins, the processing of bile, immunological defense, and the biotransformation of endogenous molecules and xenobiotics [1]. Human hepatocytes directly reflect the specific metabolism and func…
Hepatocytes are parenchymal cells that constitute as much as 80% of the total liver volume and mediate a number of vital liver functions, such as the control of lipid and carbohydrate homeostasis, the synthesis of various proteins, the storage of vitamins, the processing of bile, immunological defense, and the biotransformation of endogenous molecules and xenobiotics [1]. Human hepatocytes directly reflect the specific metabolism and func…
20-Aug-2021
A brief introduction to human tumor cell lines.
History, benefits and applications of human cancer cell lines.
Tumor cell lines (or cancer cell lines) are derived from the cancerous growths on an organ in a human or animal subject. These cell lines have undergone laboratory modifications that render them immortalized—they are capable of proliferating indefinitely in an in vitro environment. For that reason, tumor cell lines have become invaluable tools in the field of cancer research. History of Human Cancer Cell Lines In the first half of the 20th century, various experiments demonstrated that animal cell lines could be maintained in an in vitro environment. The first human cell line was established in 1951, from cervical carcinoma cells taken from 30-year-old H…
Tumor cell lines (or cancer cell lines) are derived from the cancerous growths on an organ in a human or animal subject. These cell lines have undergone laboratory modifications that render them immortalized—they are capable of proliferating indefinitely in an in vitro environment. For that reason, tumor cell lines have become invaluable tools in the field of cancer research. History of Human Cancer Cell Lines In the first half of the 20th century, various experiments demonstrated that animal cell lines could be maintained in an in vitro environment. The first human cell line was established in 1951, from cervical carcinoma cells taken from 30-year-old H…
Penn State academics are using SR-Tek transparent pressure vessels to determine optimum production conditions for biopharmaceuticals in a bid to increase yields and prevent contamination events.
Biopharmaceuticals, or biologically produced medications, are rapidly being used to treat a host of chronic and genetic conditions. Expected to be worth $535 billion by 2027, the biopharmaceutical market is currently undergoing significant growth. However, production issues are hampering the industry’s ability to meet demand. Now a research team from Pennsylvania State University is looking to tackle one of the major bottlenecks in biopharmaceutical production – purification and filtration. Led by Dr Andrew Zydney, 14 graduate students from the university are investigating system effects, including…
Biopharmaceuticals, or biologically produced medications, are rapidly being used to treat a host of chronic and genetic conditions. Expected to be worth $535 billion by 2027, the biopharmaceutical market is currently undergoing significant growth. However, production issues are hampering the industry’s ability to meet demand. Now a research team from Pennsylvania State University is looking to tackle one of the major bottlenecks in biopharmaceutical production – purification and filtration. Led by Dr Andrew Zydney, 14 graduate students from the university are investigating system effects, including…
05-Aug-2021
With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items.
With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items. However, the real advantage of 3D printing technology lies in its printing materials. Only by developing more new materials can the application fields of 3D printing technology be expanded. At present, 3D printing materials mainly include engineering plastics, photosensitive resins, rubber materials, metal materials, and ceramic materials. In addition, food materials such as colored plaster materials, artificial bone meal, cellular biological materials, and sugar can also be used in the field of 3D printing. What kind of polymer materials can be used in 3D Printing? Engineering plasti…
With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items. However, the real advantage of 3D printing technology lies in its printing materials. Only by developing more new materials can the application fields of 3D printing technology be expanded. At present, 3D printing materials mainly include engineering plastics, photosensitive resins, rubber materials, metal materials, and ceramic materials. In addition, food materials such as colored plaster materials, artificial bone meal, cellular biological materials, and sugar can also be used in the field of 3D printing. What kind of polymer materials can be used in 3D Printing? Engineering plasti…
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions.
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions. Except for insoluble coating materials or broken capsule shells, all solid preparations should pass through the screen. Therefore, a disintegration test should be carried out to make sure that a drug is rele…
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions. Except for insoluble coating materials or broken capsule shells, all solid preparations should pass through the screen. Therefore, a disintegration test should be carried out to make sure that a drug is rele…
In the past decade, major breakthroughs have been made in all aspects of material research, covering almost all material types.
In the past decade, major breakthroughs have been made in all aspects of material research, covering almost all material types. For instance, graphene, the value of which was not recognized initially, has been found to be potentially valuable in many electronic applications such as solar cells, transistors, camera sensors, digital screens, and semiconductors. Besides, research on other materials such as metals, bulk metallic glasses, high-performance alloys, ceramics and glass has been also intensified. Materials that developed quickly in the past 10 years Because composite materials and hybrid materials can withstand harsh environments, such as bulk materials, com…
In the past decade, major breakthroughs have been made in all aspects of material research, covering almost all material types. For instance, graphene, the value of which was not recognized initially, has been found to be potentially valuable in many electronic applications such as solar cells, transistors, camera sensors, digital screens, and semiconductors. Besides, research on other materials such as metals, bulk metallic glasses, high-performance alloys, ceramics and glass has been also intensified. Materials that developed quickly in the past 10 years Because composite materials and hybrid materials can withstand harsh environments, such as bulk materials, com…
29-Jun-2021
The purpose of the stability testing is to investigate how the raw materials or pharmaceutical preparations will change over time under the influence of temperature, humidity, and light, so as to provide a scientific basis for the production, packaging, storage, and transportation conditions of the drug, and to establish the validity period of the drug through the test.
The purpose of the stability testing is to investigate how the raw materials or pharmaceutical preparations will change over time under the influence of temperature, humidity, and light, so as to provide a scientific basis for the production, packaging, storage, and transportation conditions of the drug, and to establish the validity period of the drug through the test. In addition to humidity and temperature, other factors…
The purpose of the stability testing is to investigate how the raw materials or pharmaceutical preparations will change over time under the influence of temperature, humidity, and light, so as to provide a scientific basis for the production, packaging, storage, and transportation conditions of the drug, and to establish the validity period of the drug through the test. In addition to humidity and temperature, other factors…
Charnwood Molecular, a leading UK-based pre-clinical discovery CRO servicing the global pharmaceutical and biotechnology market, is pleased to announce the acquisition of the assay development and biological screening provider, Aurelia Bioscience.
The sector-leading expertise and technology development within Aurelia Bioscience will enable and enhance Charnwood’s provision of a world-class integrated drug discovery and development service platform as it continues to build upon its strong foundation in medicinal chemistry, scale-up and process research & development. Aurelia Bioscience is a leading preclinical CRO specialising in bioassay development, pharmacological profiling and compound screening, working in the early stages of the drug discovery pipeline including target identifica…
The sector-leading expertise and technology development within Aurelia Bioscience will enable and enhance Charnwood’s provision of a world-class integrated drug discovery and development service platform as it continues to build upon its strong foundation in medicinal chemistry, scale-up and process research & development. Aurelia Bioscience is a leading preclinical CRO specialising in bioassay development, pharmacological profiling and compound screening, working in the early stages of the drug discovery pipeline including target identifica…
Pharmaceutical excipients have important functions such as serving as carriers, improving drug stability, solubilization and slowing down the drug release.
Pharmaceutical excipients have important functions such as serving as carriers, improving drug stability, solubilization and slowing down the drug release. They are important ingredients that may affect the quality, safety, and effectiveness of the preparation. Classified by function and purpose, pharmaceutical excipients can be used in different drug forms, including: Injection, where pharmaceutical excipients are antioxidants, cosolvents, and isotonic regulators, etc. Oral solid preparations, where pharmaceutical excipients are lubricants, fillers, and adhesives and diluents, etc. Oral liquid preparations, where pharmaceutical excipien…
Pharmaceutical excipients have important functions such as serving as carriers, improving drug stability, solubilization and slowing down the drug release. They are important ingredients that may affect the quality, safety, and effectiveness of the preparation. Classified by function and purpose, pharmaceutical excipients can be used in different drug forms, including: Injection, where pharmaceutical excipients are antioxidants, cosolvents, and isotonic regulators, etc. Oral solid preparations, where pharmaceutical excipients are lubricants, fillers, and adhesives and diluents, etc. Oral liquid preparations, where pharmaceutical excipien…
25-May-2021
The pancreas is an organ deep in the abdomen of the human body. Although it is small in size, its physiological function and pathological changes are closely related to life. It mainly plays an important role in neutralizing stomach acid and digesting protein, fat and sugar. When performing pancreas function tests, we often see the term lipase. So what does this mean?
The pancreas is an organ deep in the abdomen of the human body. Although it is small in size, its physiological function and pathological changes are closely related to life. It mainly plays an important role in neutralizing stomach acid and digesting protein, fat and sugar. When performing pancreas function tests, we often see the term lipase. So what does this mean? What is lipase? Lipase, also known as triacylglycero…
The pancreas is an organ deep in the abdomen of the human body. Although it is small in size, its physiological function and pathological changes are closely related to life. It mainly plays an important role in neutralizing stomach acid and digesting protein, fat and sugar. When performing pancreas function tests, we often see the term lipase. So what does this mean? What is lipase? Lipase, also known as triacylglycero…
Liver cancer is the fifth most common cancer in the world and the third leading cause of cancer deaths. A healthy diet and lifestyle are the key to preventing various diseases. In recent years, probiotics, as part of a healthy diet, have received increasing attention for their role in cancer prevention and treatment, including liver cancer. Do probiotics have the potential to prevent liver cancer?
Liver cancer is the fifth most common cancer in the world and the third leading cause of cancer deaths. A healthy diet and lifestyle are the key to preventing various diseases. In recent years, probiotics, as part of a healthy diet, have received increasing attention for their role in cancer prevention and treatment, including liver cancer. Do probiotics have the potential to prevent liver cancer?…
Liver cancer is the fifth most common cancer in the world and the third leading cause of cancer deaths. A healthy diet and lifestyle are the key to preventing various diseases. In recent years, probiotics, as part of a healthy diet, have received increasing attention for their role in cancer prevention and treatment, including liver cancer. Do probiotics have the potential to prevent liver cancer?…
19-May-2021
The healthcare industry is now well into its digital transformation journey, having embraced new digital platforms in order to reduce costs while providing higher levels of service and engagement for all stakeholders, including providers, physicians, payers, and patients. The cloud is becoming ever more critical within the transformation journey.
The healthcare industry is now well into its digital transformation journey, having embraced new digital platforms in order to reduce costs while providing higher levels of service and engagement for all stakeholders, including providers, physicians, payers, and patients. The cloud is becoming ever more critical within the transformation journey and whilst the healthcare sector started cautiously – migrating non-critical and back end services – it…
The healthcare industry is now well into its digital transformation journey, having embraced new digital platforms in order to reduce costs while providing higher levels of service and engagement for all stakeholders, including providers, physicians, payers, and patients. The cloud is becoming ever more critical within the transformation journey and whilst the healthcare sector started cautiously – migrating non-critical and back end services – it…
LABWorld China 2021, organized by Informa Markets and China Chamber of Commerce for Import and Export of Medicine and Health Products and co-organized by Sinoexpo Informa Markets, will take place during 16-18 December 2021 in SNIEC Shanghai China.
Biosecurity Law has been officially implemented since 15 April 2021. Great attention has been attached to biosecurity work and a lot has been carried out in terms of national biosecurity strategy, policy and legislation. Many related tasks have been added into the provincial government reports and listed as the main objectives of China's 14th five-year plan, including but not limited to: Strengthen the biosecurity management of pathogenic microorganism laboratory, establish national key laboratories, build provincial laboratories wi…
Biosecurity Law has been officially implemented since 15 April 2021. Great attention has been attached to biosecurity work and a lot has been carried out in terms of national biosecurity strategy, policy and legislation. Many related tasks have been added into the provincial government reports and listed as the main objectives of China's 14th five-year plan, including but not limited to: Strengthen the biosecurity management of pathogenic microorganism laboratory, establish national key laboratories, build provincial laboratories wi…
