Research and development - Articles
24-Jul-2024
Digital twins are a virtual replica of a physical object, system, or process. In the pharmaceutical industry, digital twins are especially useful in drug discovery and production, but they still have much unrealized potential.
Could digital twins permanently change the pharmaceutical sector? While this cutting-edge technology already has applications in the clinical and drug production fields, it needs to be utilized more. Here’s how industry professionals can use this revolutionary technology. What Is a Digital Twin? A digital twin is a virtual replica of a physical object, individual, system or process. It replicates the asset’s form, features and functionality to produce a digitalized, three-dimensional copy that is basically indistinguishable from its real-world counterpart. The main co…
Could digital twins permanently change the pharmaceutical sector? While this cutting-edge technology already has applications in the clinical and drug production fields, it needs to be utilized more. Here’s how industry professionals can use this revolutionary technology. What Is a Digital Twin? A digital twin is a virtual replica of a physical object, individual, system or process. It replicates the asset’s form, features and functionality to produce a digitalized, three-dimensional copy that is basically indistinguishable from its real-world counterpart. The main co…
Pharmacovigilance, specifically adverse event case intake, is a prime candidate for disruption by AI. Here, ArisGlobal’s Emmanuel Belabe explores how far Generative AI and Large Language Models have come in enabling human-like decision-making and processing, and the broader opportunity beyond.
Pharmacovigilance processes are designed to uphold the safety of marketed human medinical products over time, once authorised for patient consumption, but as the ocean of available data continues to rise in volume, the task of discerning and acting on important signals is becoming ever harder. It’s odd then that approaches to post-market Safety monitoring have changed little in decades First there’s the increasing array of formats through which cases come to light, not to mention the proliferating ran…
Pharmacovigilance processes are designed to uphold the safety of marketed human medinical products over time, once authorised for patient consumption, but as the ocean of available data continues to rise in volume, the task of discerning and acting on important signals is becoming ever harder. It’s odd then that approaches to post-market Safety monitoring have changed little in decades First there’s the increasing array of formats through which cases come to light, not to mention the proliferating ran…
11-Jul-2024
The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, antibody engineering, and combinatorial approaches.
What is Antibody Cocktail Therapy? Antibody cocktail therapy is a treatment that mixes two or more monoclonal antibodies together. By combining the properties of different antibodies, this therapy can target multiple targets simultaneously, thereby enhancing the effectiveness of treatment and reducing the development of drug resistance. Antibody cocktail therapy has broad application prospects in fields such as tumors and autoimmune diseases. How to Develop Antibody Cocktail Therapy? The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, anti…
What is Antibody Cocktail Therapy? Antibody cocktail therapy is a treatment that mixes two or more monoclonal antibodies together. By combining the properties of different antibodies, this therapy can target multiple targets simultaneously, thereby enhancing the effectiveness of treatment and reducing the development of drug resistance. Antibody cocktail therapy has broad application prospects in fields such as tumors and autoimmune diseases. How to Develop Antibody Cocktail Therapy? The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, anti…
Lab-made mini-organs are revolutionizing the future of life science research with their remarkable potential. These tiny, three-dimensional structures, grown from stem cells, closely resemble real human organs. The uses of mini-organs span across various subjects, including disease modeling and drug development, offering unprecedented insights and innovative solutions to some of healthcare’s most challenging problems.
Lab-made mini-organs are revolutionizing the future of life science research with their remarkable potential. These tiny, three-dimensional structures, grown from stem cells, closely resemble real human organs. The uses of mini-organs span across various subjects, including disease modeling and drug development, offering unprecedented insights and innovative solutions to some…
Lab-made mini-organs are revolutionizing the future of life science research with their remarkable potential. These tiny, three-dimensional structures, grown from stem cells, closely resemble real human organs. The uses of mini-organs span across various subjects, including disease modeling and drug development, offering unprecedented insights and innovative solutions to some…
Scientists have predicted that the first person who will live to 150 has already been born.1 While this number may sound far-fetched, researchers have developed several interventions to extend the human lifespan. Innovations such as artificial intelligence, stem cell therapy, precision medicine, and telemedicine are changing how healthcare providers diagnose and treat illnesses, ultimately increasing the average life expectancy. But how exactly is technology helping us live longer?
Scientists have predicted that the first person who will live to 150 has already been born.1 While this number may sound far-fetched, researchers have developed several interventions to extend the human lifespan. Innovations such as artificial intelligence, stem cell therapy, precision medicine, and telemedicine…
Scientists have predicted that the first person who will live to 150 has already been born.1 While this number may sound far-fetched, researchers have developed several interventions to extend the human lifespan. Innovations such as artificial intelligence, stem cell therapy, precision medicine, and telemedicine…
There is constant innovation across industries as time passes. While other sectors are vital, life science has seen critical advancements globally. How are researchers able to achieve these fantastic breakthroughs? Consider the intersection of life sciences and technology. Here’s what you need to know about the various life sciences and their recent innovations.
There is constant innovation across industries as time passes. While other sectors are vital, life science has seen critical advancements globally. How are researchers able to achieve these fantastic breakthroughs? Consider the intersection of life sciences and technology. Here’s what you need to know about the various life sciences and their recent innovations. Why Innovations Are Critical to Life Science Research You expect parts…
There is constant innovation across industries as time passes. While other sectors are vital, life science has seen critical advancements globally. How are researchers able to achieve these fantastic breakthroughs? Consider the intersection of life sciences and technology. Here’s what you need to know about the various life sciences and their recent innovations. Why Innovations Are Critical to Life Science Research You expect parts…
RNA synthesis is a fundamental technique in molecular biology that allows researchers to design and create specific RNA molecules tailored to their experimental needs.
These custom RNA molecules play crucial roles in a wide range of applications, including gene expression studies, functional genomics, and RNA interference experiments. The process of custom RNA synthesis involves the production of RNA molecules with precise sequences and modifications, enabling researchers to investigate various biological processes with high specificity and efficiency. In RNA synthesis, there are two main methods commonly used: chemical synthesis and enzymatic synthesis. Custom chemical synthesis involves the step-by-step assembly of RNA molecules using nucleotide building blocks and chemic…
These custom RNA molecules play crucial roles in a wide range of applications, including gene expression studies, functional genomics, and RNA interference experiments. The process of custom RNA synthesis involves the production of RNA molecules with precise sequences and modifications, enabling researchers to investigate various biological processes with high specificity and efficiency. In RNA synthesis, there are two main methods commonly used: chemical synthesis and enzymatic synthesis. Custom chemical synthesis involves the step-by-step assembly of RNA molecules using nucleotide building blocks and chemic…
PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics.
About Propylene Glycol Propylene glycol (PG) is a clear, odorless, and viscous liquid that is miscible with water and many organic solvents. It is a small molecule that is structurally different and unrelated to PEG, despite a similar name. PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics. In addition, it has a wide range of other practical applications, such as antifreeze agent, cutting fluid, and as an additive to latex paints and coatings to increase freeze-thaw capabilities. Propylene Glycol as An Excipient Excipients are essential supports for active ingredients in drugs, vaccines and other products, contributing…
About Propylene Glycol Propylene glycol (PG) is a clear, odorless, and viscous liquid that is miscible with water and many organic solvents. It is a small molecule that is structurally different and unrelated to PEG, despite a similar name. PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics. In addition, it has a wide range of other practical applications, such as antifreeze agent, cutting fluid, and as an additive to latex paints and coatings to increase freeze-thaw capabilities. Propylene Glycol as An Excipient Excipients are essential supports for active ingredients in drugs, vaccines and other products, contributing…
Mtech Access are now part of Petauri. This marks a significant and exciting milestone in our journey, and aligns with our commitment to partnering with industry to bring life-enhancing technologies to market, providing more patient choice and meeting the needs of the healthcare environment.
What this means for our clients: Enhanced services: This strategic move will allow us to offer greater breadth and depth of technical and consulting experience, as well as market coverage for our clients. Continuity and stability: The quality of work and client service that you have come to expect, along with your current projects and relationships, will remain unchanged. Innovative solutions: Leveraging the strengths of the Petauri group, we will build on our commitment to growth and inn…
What this means for our clients: Enhanced services: This strategic move will allow us to offer greater breadth and depth of technical and consulting experience, as well as market coverage for our clients. Continuity and stability: The quality of work and client service that you have come to expect, along with your current projects and relationships, will remain unchanged. Innovative solutions: Leveraging the strengths of the Petauri group, we will build on our commitment to growth and inn…
19-Jun-2024
Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product.
Similarities and Differences Between Liquid Formulation and Semi-solid Formulation Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product. The similarities and differences between them are mainly reflected in the following aspects: Overall process: The preparation process of liquid preparations is usually more straightforward, which involves dissolving the drug in a solvent and completing the steps of mixing and stirring. The preparation process of semi-solid preparations requires more steps, such as mixing, heating, cooling, stir…
Similarities and Differences Between Liquid Formulation and Semi-solid Formulation Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product. The similarities and differences between them are mainly reflected in the following aspects: Overall process: The preparation process of liquid preparations is usually more straightforward, which involves dissolving the drug in a solvent and completing the steps of mixing and stirring. The preparation process of semi-solid preparations requires more steps, such as mixing, heating, cooling, stir…
13-Jun-2024
Different techniques have been developed to functionalize nanotubes, including covalent and non-covalent approaches.
Nanotubes, with their unique properties and structure, have revolutionized various fields of science and technology. Over the past few decades, tremendous efforts have been made to functionalize nanotubes, unlocking their true potential for a wide range of applications. Understanding Functionalization of Nanotubes Functionalization refers to the process of modifying the surface properties of nanotubes, enabling them to interact with specific molecules or materials. This modification plays a crucial role in tailoring the physical and chemical properties of nanotubes, making them suitable for a variety of applications. Different techniques have been developed to functionalize…
Nanotubes, with their unique properties and structure, have revolutionized various fields of science and technology. Over the past few decades, tremendous efforts have been made to functionalize nanotubes, unlocking their true potential for a wide range of applications. Understanding Functionalization of Nanotubes Functionalization refers to the process of modifying the surface properties of nanotubes, enabling them to interact with specific molecules or materials. This modification plays a crucial role in tailoring the physical and chemical properties of nanotubes, making them suitable for a variety of applications. Different techniques have been developed to functionalize…
A recent poll conducted among clinical trial professionals has highlighted the most significant trends expected to transform the industry over the next five years
A recent poll conducted among industry professionals reveals significant insights into the evolving landscape of clinical trials. With 70% of respondents identifying increased use of AI and machine learning (ML) as the biggest trend, it is clear that integrating advanced technologies will play a pivotal role in shaping the future of clinical trials. Other notable trends include the rise of decentralized trials (14%), enhanced patient engagement tools (13%), and regulatory harmonization (4%). The Future of Clinical Trials: Key Trends As the clinical trials industry evolves, it faces numerous challenges, including data management in…
A recent poll conducted among industry professionals reveals significant insights into the evolving landscape of clinical trials. With 70% of respondents identifying increased use of AI and machine learning (ML) as the biggest trend, it is clear that integrating advanced technologies will play a pivotal role in shaping the future of clinical trials. Other notable trends include the rise of decentralized trials (14%), enhanced patient engagement tools (13%), and regulatory harmonization (4%). The Future of Clinical Trials: Key Trends As the clinical trials industry evolves, it faces numerous challenges, including data management in…
The collaboration between the Centre for Process Innovation (CPI), academia, and industry leaders within pharma and digital could help medicines reach patients up to a year faster (30 April 2024).
The collaboration will develop a working model of a cloud-first manufacturing facility that will use technologies such as artificial intelligence (AI), machine learning and the Internet of Things (IoT) to accelerate the speed at which new medicines are made. Using these technologies in pharma could lead to patients gaining faster access to innovative treatments and could reduce operational costs for manufacturers by up to 30 per cent. Alongside cost reduction, digital manufacturing technologies also allow greater agility to scale production and meet changing demand, with som…
The collaboration will develop a working model of a cloud-first manufacturing facility that will use technologies such as artificial intelligence (AI), machine learning and the Internet of Things (IoT) to accelerate the speed at which new medicines are made. Using these technologies in pharma could lead to patients gaining faster access to innovative treatments and could reduce operational costs for manufacturers by up to 30 per cent. Alongside cost reduction, digital manufacturing technologies also allow greater agility to scale production and meet changing demand, with som…
Microneedle patches for the eyes and lips are small, adhesive patches that are infused with microneedles made of dissolvable materials such as hyaluronic acid or collagen.
In recent years, microneedle patches have emerged as a revolutionary technology in the beauty and skincare industry. These patches are designed to deliver active ingredients directly into the skin, providing targeted treatments for a variety of concerns. One area where microneedle patches have shown significant promise is in the treatment of the delicate skin around the eyes and lips. In this article, we will explore the latest innovations in microneedle eye and lip patch technologies, including advancements in manufacturing processes and delivery methods. Microneedle Eye and Lip Patch Microneedle patches for the eyes and…
In recent years, microneedle patches have emerged as a revolutionary technology in the beauty and skincare industry. These patches are designed to deliver active ingredients directly into the skin, providing targeted treatments for a variety of concerns. One area where microneedle patches have shown significant promise is in the treatment of the delicate skin around the eyes and lips. In this article, we will explore the latest innovations in microneedle eye and lip patch technologies, including advancements in manufacturing processes and delivery methods. Microneedle Eye and Lip Patch Microneedle patches for the eyes and…
The field of pharmaceuticals has seen rapid advancements in drug delivery technologies in recent years, one of which is long-lasting controlled-release microspheres technology.
The field of pharmaceuticals has seen rapid advancements in drug delivery technologies in recent years, one of which is long-lasting controlled-release microspheres technology. This technology involves the use of microscopic particles to deliver drugs in a controlled and sustained manner over an extended period of time. By encapsulating drugs within these microspheres, pharmaceutical companies are able to improve patient compliance, reduce dosing frequency, and enhance therapeutic outcomes. In this article, we will explore the benefits and applications of long-lasting controlled-release microspheres technology. Long-…
The field of pharmaceuticals has seen rapid advancements in drug delivery technologies in recent years, one of which is long-lasting controlled-release microspheres technology. This technology involves the use of microscopic particles to deliver drugs in a controlled and sustained manner over an extended period of time. By encapsulating drugs within these microspheres, pharmaceutical companies are able to improve patient compliance, reduce dosing frequency, and enhance therapeutic outcomes. In this article, we will explore the benefits and applications of long-lasting controlled-release microspheres technology. Long-…
PEG is soluble in organic solvents and water has excellent physicochemical and physiological properties, and is non-toxic, non-antigenic, and non-immunogenic. PEG is biocompatible and exhibits low protein and platelet adsorption in vivo as well as low cellular adherence, which are features that have led to a wide range of applications in biomedical fields.
Polymers play an important role in the biomedical field, and polyethylene glycol (PEG) and its derivatives are among the multifunctional polymers that have attracted much attention. PEG is a synthetic macromolecule with a linear structure consisting of glycol units (-CH2CH2O-) repeatedly linked. Its unique properties give PEG a wide range of applications. PEG is soluble in organic solvents and water has excellent physicochemical and physi…
Polymers play an important role in the biomedical field, and polyethylene glycol (PEG) and its derivatives are among the multifunctional polymers that have attracted much attention. PEG is a synthetic macromolecule with a linear structure consisting of glycol units (-CH2CH2O-) repeatedly linked. Its unique properties give PEG a wide range of applications. PEG is soluble in organic solvents and water has excellent physicochemical and physi…
Lipids, a broad group of naturally occurring molecules, continue to play a significant role in various chemical processes. The analysis and characterization of lipids are critical steps in achieving effective chemical practices in several industries, including the chemical industry. Lipids can function as bio-active compounds in pharmaceuticals, ingredients in cosmetic products, and additives in biofuel production. Their diverse group of fats, oils, sterols, waxes, and other related compounds, provide a key resource for the chemical industry.
The chemical industry applies lipid analysis and characterization in creating specialty chemicals and polymers. Lipids can serve as raw materials in polymer chemistry. For instance, lipid-based monomers can be polymerized to produce high-value pla…
The chemical industry applies lipid analysis and characterization in creating specialty chemicals and polymers. Lipids can serve as raw materials in polymer chemistry. For instance, lipid-based monomers can be polymerized to produce high-value pla…
SN38-BSA is a bioconjugate product that is effectively revolutionizing the field of drug delivery. This article focuses on understanding its makeup and how bioconjugation is instrumental in its function and efficacy.
To begin with, SN38-BSA is composed of SN38, a potent anti-cancer drug, and BSA or Bovine Serum Albumin. SN38 is the active metabolite of the prodrug irinotecan, commonly used in chemotherapy. It's known for its high potency against cancer cells but has limitations in terms of bioavailability and solubility. BSA, on the other hand, is a protein derived from cows that has found extensive uses in biochemistry, including as a carrier protein for drugs. Bioconjugate chemistry is the chemical bonding of two biomolecules, enabling them to create hybrid molecules with new…
To begin with, SN38-BSA is composed of SN38, a potent anti-cancer drug, and BSA or Bovine Serum Albumin. SN38 is the active metabolite of the prodrug irinotecan, commonly used in chemotherapy. It's known for its high potency against cancer cells but has limitations in terms of bioavailability and solubility. BSA, on the other hand, is a protein derived from cows that has found extensive uses in biochemistry, including as a carrier protein for drugs. Bioconjugate chemistry is the chemical bonding of two biomolecules, enabling them to create hybrid molecules with new…
The fast-tracking landscape of contemporary gene therapy demands continuous advances in AAV (Adeno-associated virus) formulation development and the enhancement of cGMP (Current Good Manufacturing Practice) capacity. Together, these transformations are essential in producing safe and effective gene therapies for patients.
AAV Formulation Development: A Primary Focus In the field of gene therapy, AAV formulation development has gained significant focus. AAV vectors are used as delivery vehicles or "vectors" to administer therapeutic genes into patient's cells. This therapeutic gene, once inside the cell, generates a functional protein to correct or counter the effects of the disease-causing genetic mutation, providing a basis for curing several genetic diseases. The AAV's natur…
AAV Formulation Development: A Primary Focus In the field of gene therapy, AAV formulation development has gained significant focus. AAV vectors are used as delivery vehicles or "vectors" to administer therapeutic genes into patient's cells. This therapeutic gene, once inside the cell, generates a functional protein to correct or counter the effects of the disease-causing genetic mutation, providing a basis for curing several genetic diseases. The AAV's natur…
Mycotoxins and GMP fermentation are two key components to consider in today's food and beverage industry. With the increasing demand for high-quality and safe food products around the globe, it's important to understand the significance of these aspects in the production process.
Mycotoxins are toxic secondary metabolites produced by certain fungi. They can contaminate a wide range of commodities, from grain to dried fruits, spices, coffee, and cocoa. They represent a genuine health risk for both humans and animals, causing various diseases referred to as mycotoxicoses. Certain mycotoxins are carcinogenic, immune-suppressing, neurotoxic, or cause damage to organs like the liver. Hence, reducing and controlling mycotoxin levels in food products is of utmost importance. One possible wa…
Mycotoxins are toxic secondary metabolites produced by certain fungi. They can contaminate a wide range of commodities, from grain to dried fruits, spices, coffee, and cocoa. They represent a genuine health risk for both humans and animals, causing various diseases referred to as mycotoxicoses. Certain mycotoxins are carcinogenic, immune-suppressing, neurotoxic, or cause damage to organs like the liver. Hence, reducing and controlling mycotoxin levels in food products is of utmost importance. One possible wa…
