Research and development - Articles

Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University of Copenhagen), Michael Egholm (University of Copenhagen), Rolf H. Berg (Risø National Laboratory), Technical University of Denmark) and Ole Buchardt (University of Copenhagen) invented it in 1991.
Applications of PNA include altering gene expression, serving as inhibitors and promoters, antigene and antisense therapeutics, anticancer agents, antiviral agents, antibacterial and antiparasitic agents, molecular tools and probes for biosensors, DNA Sequence detection and nanotechnology. Genome editing In October 2022, Neubase shifted the focus of its PNA business to gene editing. Neubase, in partnership with a g…

In recent years, various nucleic acid-based therapies (NBT) have emerged as effective and specific activators of endogenous gene expression.
Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and subcellular localization. Currently, the US Food and Drug Administration (FDA) and the European Medicines Agency have approved several therapies targeting splicing mechanisms to regulate mutations in exons. These methods can increase the expression of coding and non-coding genes specifically and controllably, reducing development and manufacturing costs and thus expanding the range of treatable diseases. B…

From nurturing a positive work culture to empowering and developing your people for success, Pioneer Group sets out some top tips for building a high-performance team as a life science company.
When it comes to recruitment, the life sciences industry is undoubtedly highly competitive. With demand for skilled professionals often outpacing the supply, attracting (and retaining) qualified candidates with the right expertise can be a significant challenge for many life science companies. From nurturing a positive work culture to empowering and developing your people for success, Pioneer Group sets out some top tips for building a high-performance team as a life science company. Invest in Graduate Programmes Investing in graduate outreach can help to bridge the skills gap in life sciences, and…

One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body.
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body. In this article, we will explore different types of nanoparticle development that are revolutionizing…

Oxide nanoparticles have found applications in the field of medicine and healthcare. Metal oxide nanoparticles, such as iron oxide nanoparticles, are widely used as contrast agents in magnetic resonance imaging (MRI) due to their paramagnetic properties.
Oxides nanoparticles have gained significant attention in various fields due to their unique properties and potential applications. Synthesis Methods of Oxides Nanoparticles The synthesis of these nanoparticles requires careful consideration of the method employed, as it can greatly influence their physical and chemical characteristics. Chemical Precipitation Method The chemical precipitation method is one of the most widely used techniques for the synthesis of oxides nanoparticles. In this method, a precursor solution containing metal…

In recent years, some studies have been conducted on the delivery of anticancer drugs, genes and peptides through garphene derivatives.
The Importance of Drug and Gene Delivery Due to its poor water solubility, non-specific delivery and severe side effects, chemotherapy drugs have many limitations in fighting cancer clinically. On the other hand, gene therapy has also been widely explored as another option for cancer treatment, but the lack of safe, selective and effective gene delivery vectors hinders the further clinical application of gene therapy. Recently, various nanomaterial-based drug and gene delivery systems have been intensively studied and proved to be promising in cancer treatment. Accelerate Research and Practice of Graphene in Drug and Gene Delivery Graphene is cons…

Genes are the basic unit of inheritance. They're like a blueprint containing biological information your parents can pass on to you, identifying certain traits you acquire, such as the color of your hair, eyes and skin. However, it turns out genes can transfer more than just physical traits — a recent study shows they can also be the cause of your sleeping difficulties.
Genes are the basic unit of inheritance. They're like a blueprint containing biological information your parents can pass on to you, identifying certain traits you acquire, such as the color of your hair, eyes and skin. However, it turns out genes can transfer more than just physical traits — a recent study shows they can also be the cause of your sleeping difficulties. Can you be genetically predisposed to insomnia? Learn…

Refractory Material Market Size was valued at USD 19.9 Billion in 2022. The Refractory Material industry is projected to grow from USD 20.93 Billion in 2023 to USD 31.40 Billion by 2032, exhibiting a compound yearly growth rate (CAGR) of 5.20% during the forecast period (2023 - 2032).
Introduction: The global refractory material market is undergoing significant transformations driven by advancements in technology, increasing demand from various industries, and a growing emphasis on sustainable solutions. Refractory materials play a crucial role in high-temperature applications, providing resistance against heat, corrosion, and wear. This article explores the key trends and innovations that are shaping the refractory material market. Advanced Manufacturing Techniques: The refr…

● At the 17th International Conference on Advanced Technologies and Treatments for Diabetes (ATTD) in Florence, Italy, Roche shared recent accuracy data for its new Accu-Chek SmartGuide solution for real-time continuous glucose monitoring (rtCGM). ● International experts discussed how a novel CGM solution using prediction capabilities can address unmet needs of people with diabetes at the Roche symposium. ● The presented study results underlined the accurate and safe performance of the solution.
Roche (SIX: RO, ROG; OTCQX: RHHBY) presented the latest data on its novel solution for continuous glucose monitoring. The solution consists of a CGM sensor and two apps designed to display current glucose values and predictions over 30 minutes and two hours. In addition, it features a risk predi…

The Mental Health Screening market is projected to reach USD 1.8 billion by 2029 from USD 0.9 billion in 2023, at a CAGR 12.2% from 2023 to 2029
According to a new report by MarketsandMarkets™ – Mental Health Screening Market in terms of revenue was estimated to be worth $0.9 billion in 2023 and is poised to reach $1.8 billion by 2029, growing at a CAGR of 12.2% from 2023 to 2029. The growth in the Mental Health Screening market is driven by the growing geriatric population and subsequent increase in the prevalence of mental disorders, rising awareness of mental health issues, technological advancements, and the increasing focus on remote monitoring. The adoption of mental health screening tools is also expected to increase with the integration with wearable technologies and the…

Molecular sieves are highly porous materials that have the ability to adsorb molecules based on size and shape. They are commonly used as desiccants (absorbing moisture) or as adsorbents for various gases and liquids.
What is Molecular Sieve? Molecular sieves are highly porous materials that have the ability to adsorb molecules based on size and shape. They are commonly used as desiccants (absorbing moisture) or as adsorbents for various gases and liquids. Molecular sieves, with their unique properties and structure, have become indispensable in various scientific and industrial applications. Environmental Applications of Molecular Sieve 1. Removing Pollutants from Wastewater: Molecular sieves offer an effective solution for treating wastewater by adsorbing and removing harmful pollut…

Specialists from across Mtech Access look at each of ISPOR’s top 10 HEOR trends for 2024–2025. Jump in as our experts give their hot take on each trend, sharing their perspectives on the topics in these areas (get ready – it’s a jam-packed read!).
    Executive Summary Hayley Shoel and Abigail Beveridge, from our Medical Writing Team, outline what to expect from this paper in the below Executive Summary. In January 2024, ISPOR published their ‘2024–2025 Top HEOR Trends’ report, a horizon scanning publication that highlighted key trends affecting healthcare decision-making around the world. Since these trends resonate with our own research and activities here at Mtech Access, experts within our team have come together to share their perspectives on each of the t…

A highly active Ag3PO4 product with exposed {110} crystal planes was prepared by hydrothermal reaction using AgNO3 and H3PO4 as raw materials and urea hydrolysis to adjust the pH value of the system.
Silver phosphate (Ag3PO4) is one of the ideal candidate materials in the field of photocatalysis due to its low toxicity, wide photoresponse range, and good photocatalytic performance, and has attracted wide attention from people from all walks of life. So far, researchers have prepared Ag3PO4 through various methods, which will provide technical support for the development and utilization of Ag3PO4, and other Ag-based or PO4-based photocatalysts can also learn from its preparation methods. Preparation Methods 1. Solid phase grinding method The solid phase grinding method uses grindin…

Hydrogen carbonate, also called bicarbonate, is an acid salt formed from carbonic acid and contains hydrogen carbonate ions. Hydrogen carbonate is a commonly used chemical reagent.
What is hydrogen carbonate? Hydrogen carbonate, also called bicarbonate, is an acid salt formed from carbonic acid and contains hydrogen carbonate ions. Most hydrogen carbonates are thermally unstable and decompose into carbonates, carbon dioxide and water. Alkali metal hydrogen carbonate is soluble in water, and it can react with acid rapidly to release carbon dioxide gas, and the corresponding normal salt carbonate can be obtained by adding alkali. Common hydrogen carbonates are soluble in water. Such as: potassium bicarbonate, sodium bicarbonate, calcium bicarbonate, and other bicarbonates …

Despite Alzheimer’s being discovered over 100 years ago, the complexity of the brain and limitations surrounding research/diagnostic methods have historically acted as barriers for Alzheimer's disease (AD) drug development. As a result, market authorisations for AD have been particularly low, with only four drugs treating the symptoms, rather than the causes, approved between 1996 and 2020.
Despite Alzheimer’s being discovered over 100 years ago, the complexity of the brain and limitations surrounding research/diagnostic methods have historically acted as barriers for Alzheimer's disease (AD) drug development. As a result, market authorisations for AD have been particularly low, with only four drugs treating the symptoms, rather than the causes, approved between 1996 and 2020. Recently, how…

The COVID-19 pandemic has killed millions of people. Vaccines certainly are the most outstanding ways to prevent major diseases and death, though they haven't eliminated infections. At present, the most effective vaccine is the mRNA vaccine developed by Pfizer-BioNTech and Moderna. Before that, mRNA technology stopped in the lab phase. How to apply mRNA technology to more complex diseases in the future? The ideal and safe delivery vector may be the answer.
Although lipid nanoparticles (LNPs) are the most advanced mRNA delivery carriers in clinical practice, further optimization is still ongoing. An ideal ionizable cationic lipid needs to meet three characteristics: The ionizable hydrophilic amine head can fully realize mRNA enrichment Hydrophobic hydrocarbon tail can promote self-assem…

Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and complex chemical structure, extensive and significant biological activity, unique mechanism of action, and scarce natural resources have gained immense favor among botanists, chemists, pharmacologists, and molecular biologists, making it a prominent anticancer star and research focus in the latter half of the 20th century.
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and comp…

The cosmetics and skincare industry is constantly evolving and a recent trend that has emerged is the use of fermented ingredients in skincare products. Fermentation is a microbial metabolic process that has been used for centuries in food and beverage production, and now it has been extended to the cosmetic industry.
What are Fermented Raw Materials? Fermented raw materials are natural ingredients that have undergone a fermentation process. The substrates of fermentation utilized in cosmetics industry include rice, soybeans, milk, and fruits. The substrates are used by microorganisms like yeast, bacteria, and fungi for metabolism or biosynthesis to create beneficial compounds that served as the fermented raw materials for cosmetic skincare product. Here are a few examples of fermentation-g…

Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of diabetes is increasing year by year.
Diabetes has various types and requires long-term treatment. Antidiabetic drugs are essential for people with the disease. These drugs can be classified into insulin injections and oral antidiabetic medications. Commonly used oral antidiabetic drugs in clinical practice include biguanides (such as metformin), sulfonylurea insulin secretagogues (e.g., glimepiride, glipizide, gliclazide), non-sulfonylurea insulin secretagogues (e.g., repaglinide, nateglinide), α-glucosidase inhibitors (acarbose, voglibose, miglitol), DPP-4 inhibitors (sitagliptin, etc.), and GLP-1 rec…

Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages.
What is a Nanobody? The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in biological function and biochemical characteristics. Therefore, nanobodies have shown good control effects in disease diagnosis, cancer and infectious diseases. What are Nanobody-Drug Conjugates (NDCs) The development concept of nanobody-drug conjugates (NDCs) is similar to that of antibody drug conjugates (ADC), that is, the antibody in ADC is replaced by a nanobody with higher affinity. Because nanobod…