Articles

Mojgan Sani has recently taken over the role of Chief Pharmacist at North Tees and Hartlepool NHS Foundation Trust. Here she talks about how the automation of medication management can help meet many of the challenges currently facing the NHS.
Accessibility to social care isn’t the only issue causing bed blocking across the NHS – pharmacy have a crucial role to play in freeing up bed space too. As a profession, we need to look at streamlining the process for To Take Out (TTO) medication and how automation can achieve this.  The latest annual inpatient survey by the Care Quality Commission found 73% of patients “whose discharge had been delayed” said the main reason was “that they had to wait for medicines”.  Of the 76,668 patients who responded more than a quarter said they had wa…

Resistance to anticancer drugs results from a variety of factors, and individual genetic difference is just one of them. This article is about how to overcome drug resistance against KRAS inhibitors in cancer treatment.
Recently, KRAS and KRAS-G12C mutant inhibitors, which were previously considered to be "non-drugable" targets, have ignited a development boom. However, KRAS inhibitors are not a "magic bullet" for once and for all. Drug resistance is a major problem that frequently occurs in cancer treatment. In clinical practice, tumor tissue becomes significantly smaller after targeted therapy, but soon deteriorates again. Such scenes are commonly observed in real situations. Amgen's latest clinical trial results also indicate that some patients treated with the KRAS-G12C inhibitor AMG 51…

The severe side effects of conventional chemotherapeutic treatments can’t be ignored since in most cases, the valid drug dose that can remove the tumor are too toxic for patients. To solve the limitations, the antibody drug conjugates (ADCs) have emerged consisting of tumor-selective antibody-linked drugs, with the potential to significantly broaden the therapeutic range.
The severe side effects of conventional chemotherapeutic treatments can’t be ignored since in most cases, the valid drug dose that can remove the tumor are too toxic for patients. To solve the limitations, the antibody drug conjugates (ADCs) have emerged consisting of tumor-selective antibody-linked drugs, with the potential to significantly broaden the therapeutic range.   Antibody-drug conjugates (ADCs), the focus o…

Dr. Dennise Broderick, President and Managing Director of global speciality pharmaceutical company, Galen, was the first member to participate in Northern Ireland Chamber of Commerce and Industry’s CEO Spotlight Series.
Craigavon, N.I., 7 Oct 2019 - Dr. Dennise Broderick, President and Managing Director of global speciality pharmaceutical company, Galen, was the first member to participate in Northern Ireland Chamber of Commerce and Industry’s CEO Spotlight Series. Supported by KPMG, the series, which was formally launched on Thursday 3rd October, aims to inspire business growth in local companies through exchanging leadership stories of successful entrepreneurs and senior managers. The inaugural event took place at KPMG’s Soloist Building in Belfast and consisted of a business breakfast fe…

Enzymes, in other words, are just proteins. Since there are only a lot of enzymes for industrial use in the future, it is known that the future development and optimization of catalytic proteins is essential. So what is enzymes development and optimization?
The interpretation of enzymes in the modern industry certainly does not refer to yeast, but to proteins with catalytic functions. As a natural catalyst, enzymes promote various chemical reactions in cells and play a vital role in the existence of living organisms. From the concept of enzymes, to the mature industrial enzyme production, it has probably gone through 130-40 years. The Greek translation of the enzyme is "in yeast", meaning from yeast. In 1897, after the methods of disruption for yeast, the extract obtained had the…

North America Dental Equipment Market Research Report By Product (Dental Radiology Equipment, Dental Hand Pieces, CAD/CAM), Application (Examining The Mouth & Teeth, Cavity Removal, Condensing Filling Materials), End User –  Forecast To 2023
North American Dental Equipment Market Overview Over the last two hundred years, dentistry has made countless strides and also experienced a few setbacks globally. Though, the ultimate goal of the profession has always remained the same, which is to meet the treatment needs of the patient. Dental technology remains an important and valuable key to providing excellence in patient care. The role of today’s dental specialist has extended and evolved to being a gatekeeper of new product information, advisor on new restorative materials, imaging devices and…

Compared to polyclonal antibodies, monoclonal antibodies have multiple advantages, featured by strong specificity for a single epitope, little or no variability, and the easy operation to modify and customize in terms of different needs, thereby turning out to be the most suitable candidate for recombinant antibodies (rAbs). The rAbs are obtained through sequencing of the animal's immune cells and inserting the gene into a suitable cell strain, such as bacterium, yeast, and mammalian cells. Even if the original cell strain dies or is mutated, the desired cell strain can be generated by gene insertion since the antibody is definitive.
In general, polyclonal antibodies are made by collecting blood from an immunized animal stimulated with a target antigen, which can be provided all the time as…

Bispecific antibody (BsAb) is an artificially engineered antibody that can simultaneously bind two specific epitopes or target proteins with some special biological functions, such as directly targeting effector cells to tumor cells, to enhance cytotoxicity, improve antibody selectivity and functionality, and avoid immune escape mechanisms, thereby improving therapeutic efficacy. BsAb also reduces the cost of drug development and clinical trials compared to the combination of two monoclonal antibody drugs.
Bispecific antibody (BsAb) is an artificially engineered antibody that can simultaneously bind two specific epitopes or target proteins with some special biological functions, such as directly targeting effector cells to tumor cells, to enhance cytotoxicity, improve antibody selectivity a…

Investment in biotechnology has been on the rise for nearly a decade, with biotech startups raising just shy of 29 billion USD in 2018. For smart investors, due diligence is now a necessity, as it can make the difference between landing a possible billion-dollar blockbuster or a multi-million dollar dud.
In recent years the biotech and pharmaceutical industries have seen an unprecedented increase in investment. Both large pharma and investors are all searching for the next big thing to expand their portfolios and continue growth. Risk is high and a key part of mitigating this is effective due diligence. Simply put, due diligence is the investigation of a business or asset prior to signing a contract. As with any transaction, information is never perfect and the concept is that by conducting…

Enzymes, as a biologically active catalyst, also have some special properties compared to other industrial catalysts. Understanding these characteristics is of great significance for us to understand enzymes, and better utilize enzymes for industrial use and production.
Cellular activity carrying out in the living body depends on different chemical reactions. If there is no enzyme, then the body's metabolism and other life-related reactions can only be carried out at an extremely slow rate. Under such circumstances, life activities cannot be maintained. Scientists predict that if there is no enzyme, the body temperature needs to reach about 300 °C to digest food.   The human body may lack certain enzymes for some reasons, causing the reaction catalyzed by the enzyme to be abnormal, and…

More than 2,000 enzymes have been identified, and each enzyme is involved with one specific chemical reaction. Enzymes are therefore substrate-specific. They are grouped into a half-dozen classes on the basis of the kinds of reactions they take part in.
Enzymes are key protein molecules in living systems. Once synthesized, they are not usually converted to other kinds of molecules, and so are the substances taken in as fuel for digestive and respiratory processes (such as sugar, fat, and molecular oxygen). This is because enzymes are catalysts, which means they can participate in chemical reactions without themselves being changed, just like the moderator of a public debate who ideally moves the participants and the audience toward a conclusion by dictating the terms of the argument while n…

Here are the top Pharma and Life Science recruitment organisations advertising in September on PharmiWeb.jobs.
Barrington James Clinical - 206 Jobs RBW Consulting - 163 Jobs i-Pharm Consulting - 141 Jobs CHASE - 133 Jobs SEC Recruitment - 116 Jobs ID Search & Selection - 86 Jobs Clinical Professionals Ltd - 85 Jobs Hobson Prior - 76 Jobs CK Clinical - 68 Jobs Barrington James Europe - 63 Jobs X4 Life Sciences - 63 Jobs Advanced Regulatory (UK & Europe) - 60 Jobs Barrington James Medical / Executive - 58 Jobs Thornshaw Recruitment - 56 Jobs Barrington James Scientific - 48 Jobs Only Medics Recruitment ltd - 46 Jobs Planet Pharma Staffing Limited - 45 Jobs Umbilical Life - 44 Jobs ProClinical Ltd - 39 Jobs CTC Resourcing Solutions - 34 Jobs Volt - 31 Jobs Haybury - 31 Jobs Advanced S…

A list of the TOP Pharma Companies who are hiring this month (September)
Covance - 388 Jobs BSI Group - 167 Jobs PRA Health Sciences - 105 Jobs PPD- 81 Jobs Roche - 77 Jobs Synteract- 74 Jobs United BioSource Corporation. - 69 Jobs Cytel - 68 Jobs Syneos Health - 52 Jobs CROMSOURCE - 51 Jobs IQVIA - 36 Jobs AstraZeneca - 36 Jobs Celgene - 32 Jobs IQVIA Biotech - 21 Jobs Oxford BioMedica (UK) Limited - 16 Jobs Lonza - 16 Jobs Grunenthal GmbH - 14 Jobs   Register and Upload Your CV Now

Lactose intolerance begins at different ages. Lactose intolerance can affect children at 2 years age or older. And it is more common for adults. One way to treat is to avoid drinking dairy products. However, this can lead to a lack of important nutrients and vitamins such as calcium, vitamin D, riboflavin and protein. Some people use lactose-free milk or milk substitutes such as soy milk or rice syrup. What are the sources of lactase?
Whether you are an adult or a child, milk is one of the necessities for our life. The main reason is that milk has a high nutritional value. However, lactose intolerance occurs on many adults, and this symptom is more likely to occur as gastrointestinal function declines. Lactose intolerance occurs when a person's body produces only a small amount of lactase.…

As a class of proteins with biocatalytic properties, an enzyme is a biocatalyst with a high degree of specificity and extremely high catalytic efficiency. The metabolism of all living things is carried out under the influence of various enzymes.
As a class of proteins with biocatalytic properties, an enzyme is a biocatalyst with a high degree of specificity and extremely high catalytic efficiency. The metabolism of all living things is carried out under the influence of various enzymes. Each organism produces multiple enzymes as well as preserves them. Preparations having an enzyme-derived property extracted from an organism are called enzyme preparations. Enzyme preparations dedicated to food processing are called food enzyme preparations.   Enzymes have had a natural connection with…

Enzymes are a very important class of biocatalysts. Due to the action of the enzyme, the chemical reaction in the living body can be carried out efficiently and specifically under extremely mild conditions.
Enzymes are a very important class of biocatalysts. Due to the action of the enzyme, the chemical reaction in the living body can be carried out efficiently and specifically under extremely mild conditions. The life processes of every creature on the earth, from small to large, proliferating, living and dying, and metabolism, are all related to enzymes. Without enzyme catalysis, the most basic food digestion, oxygen breathing cannot be carried out, let alone other life activities. In fact, almost all kinds of reactions occurring in living organisms are carried out by enzyme catalysis. &…

Enzymatic activity also helps to accelerate chemical reactions in some products that are often used or consumed. For example, many cheese manufacturers must understand how enzymes promote cheese production. Some cheese makers use lactic acid to make cheese, which is safe for people who are lactose-resistant.
Enzymes are molecules that accelerate chemical reactions in biological organisms, including plants, animals, and bacteria. They are often referred to as catalysts because they initiate or accelerate these chemical reactions. In apples, various enzymes are involved in metabolic pathways leading to growth, maturation and browning. The name of the enzyme ends with "ase", while the first part of the name usually refers to the starting materials used to produce the new compounds.   Once…