Articles

Alzheimer's disease is one of the most common neurodegenerative disorder for the elderly. Early-onset Alzheimer's is rare that develops before age 65, primarily genetically influenced. Generally, the patients older than age 65 who account for a large proportion among the whole patients suffer from late-onset Alzheimer’s. The patients with late-onset Alzheimer’s have to fight against a series of frustrating symptoms, such as memory loss, poor language skills, unstable emotions, and no self-care ability, which may lead to numerous troubles or burden for themselves and the family members.
Alzheimer's disease is one of the most common neurodegenerative disorder for the elderly. Early-onset Alzheimer's is rare that develops before age 65, primarily genetically influenced. Generally, the patients…

For quite a long time, it remains a puzzle as to what causes Alzheimer's disease. There are different opinions on this matter. Previously, tau and β-amyloid are to blame. In this article, let's see what new findings have been discovered.
Overactive neurons in specific regions of the brain are thought to be early disturbances of Alzheimer's disease. In a new study, researchers from the Technical University of Munich, Germany, were the first to explain the causes and mechanisms of this early neurological dysfunction. They found that the excitatory neurotransmitter glutamate persisted for too long in the vicinity of active neurons. This causes these neurons to suffer from pathological over-stimulation, which is likely to be a key factor in learning and memory loss in patients with Alzheimer'…

Small-molecule inhibitors are a well-established class of potential useful drugs. Our products are included in all kinds of fields of Medical and Pharmaceutical research, such as Neurological Disease, Cancer, Metabolic Disease and so on. This article deals with the most concerned questions about small molecule inhibitors.
In recent years, many new therapy approaches has emerged in the field of cancer treatment. The monoclonal antibody drugs approved each year is on the rise, and the immunotherapy represented by anti-PD-1/PD-L1 antibody is rewriting the pattern of cancer treatment. In addition, cell therapy, represented by CAR-T therapy, is officially on the stage, bringing a totally different treatment to blood cancer. Facing these endless stream of advanced therapies, traditional small mol…

Extensive research in the field of industrial enzymes has shown their use in various industries. Nowadays, many industries have begun to explore the superiorities of industrial enzymes in their production and processes, thus establishing a good market.
Enzymes can be utilized in numerous fields, such as enzymes for diagnostics and enzymes for cancer treatment. Due to the action of the enzyme, the chemical reaction in the organism can be effectively carried out under very mild conditions, enabling the organism to digest food, absorb nutrients, and maintain visceral functions such as anti-inflammatory detoxification, metabolism, immunity, energy production, blood promotion, circulation, etc. The body contains a variety of enzymes that control many metabolic processes such as metabolism, nutri…

A reasonable diet and adequate nutrition can improve the health of a generation, prevent a variety of diseases, prolong life and improve the physical fitness of the entire nation. Unreasonable diet, excessive or insufficient nutrition will bring different degrees of harm to health.
People get all the nutrients and energy they need through food. A reasonable diet and adequate nutrition can improve the health of a generation, prevent a variety of diseases, prolong life and improve the physical fitness of the entire nation. Unreasonable diet, excessive or insufficient nutrition will bring different degrees of harm to health. Overeating can lead to obesity, diabetes, cholelithiasis, hyperlipidemia, high blood pressure and other diseases due to overnutrition, and even induce mesothelioma, such…

In the past five years, research has suggested that informatics and data analytics could save the health service anywhere between £16.5 billion and £66 billion per year. As technology unlocks new data sets and more sophisticated tools of analysis, our ability to harness information will be key to driving better health outcomes and more sustainable models of care. Steve Bradley, Group Managing Director at Cegedim UK, outlines how data holds the key to better patient care.
Power to the patient: the value of longitudinal data Steve Bradley, Group Managing Director, Cegedim UK, outlines how data holds the key to better patient care. It’s no secret that the digitisation of healthcare services and smarter use of patient data can have a transformative impact on the NHS. In the past five years, re…

Between 2017-2018, NHS England spent £173m on blood glucose (SMBG) test strips alone to care for diabetes patients. With an increasing number of people diagnosed with type 2 diabetes, there is a clear need to cost save by rationalising the number of SMBG systems in use. By encouraging CCGs and prescribers to consider more cost-effect alternatives and identifying opportunities for efficiency savings, while retaining high standards of accuracy, now is the time to recognise and adopt best practice in formulary implementation David Englefield, Spirit Healthcare outlines how CCGs can change how they manage and implement their formulary in the below article.
Reducing the cost of SMBG test strips  With the latest news from NHS England highlighting that £700 million cost savings have…

A complex problem requires a sophisticated resolution. The good news is that the technology is out there to help manufacturers tackle these challenges posed by counterfeiters. In the article, Bart Vansteenkiste, Global Life Science Sector Development Manager at Domino Printing Sciences plc, explains the different areas of packaging that are under threat by counterfeiters and how to avoid them.
Underground criminals producing counterfeit goods have become alarmingly good at replicating manufacturers’ branding and are infiltrating the market. That’s a significant problem for both manufacturers and consumers, and the scale of the issue is rising. Counterfeit products can present terrifying dangers. These falsified products are then made to look authentic thanks to replicated labelling that app…

If you’re upgrading or implementing a new hospital reporting system, what key questions do you need to ask to ensure that the technology provides you with the data set you need to ensure your organisation is safe operationally
DR MARK RATNARAJAHManaging Director (UK), C2-Ai - providing unique risk-adjusted systems for individualised patient risk prediction, avoiding harm and mortality in hospitals. In August this year, the Prime Minister pledged £250m to boost artificial intelligence and genomic testing in the NHS citing, amongst others, the benefits of harnessing NHS data. The long-term vision is to help the NHS become a world leader in utilising innovation and technology.At the time, Health Secretary Matt Hancock commented; “We are on the cusp of a huge health tech revolution that co…

Enzymes are nothing but the necessary proteins that maintain the various biological and chemical functions within the body and these include processes like digesting food to activating the brain and thousands of others. Enzymes act as a catalyst for millions of reactions that happen within the body, that make us grow, sleep, communicate, get hungry, feel and many more. Overall, it makes us live.
The growth and reproduction of life, birth and death, and metabolism are all related to enzymes. Without the catalysis of enzymes, humans can't even carry out the most basic life activities, such as food digestion, oxygen breathing, etc., let alone other problems. In fact, almost all kinds of reactions occurring in living organisms are carried out by enzyme catalysis. We can even say that the existe…

According to the different nutrient modes of microalgae, the culture modes can be divided into photoautotrophic culture, mixed culture and heterotrophic culture. And according to the different culture methods, the culture of microalgae can be divided into batch culture, fed-batch culture, semi-continuous culture and continuous culture. This article introduces the cultivation of microalgae.
m the physiological point of view, most microalgae should have the ability to grow heterotrophically. The growth process of microalgae using organic matter mainly has two forms: one is that microalgae can use organic matter to carry out heterotrophic growth under completely dark conditions, and there is no difference between the general chemical heterotrophic organisms; another form is that microalgae us…

As more routine PV work is automated, and as technology literacy moves up the qualifications & experience wish list, a serious review of resourcing and education strategies is needed. That’s if the life sciences industry is going to have fit-for-purpose PV teams in future.
As more routine PV work is automated, and as technology literacy moves up the qualifications & experience wish list, a serious review of resourcing and education strategies is needed. That’s if the life sciences industry is going to have fit-for-purpose PV teams in future. Drawing on her many years in pharma operations management, Anna Lukyanova, COO of Arriello, assesses the growing talent gap and suggests how the industry might address it. It seems remarkable that the people currently assuming pharmacovigilance rol…

The rapid rise of molecular enzymology and enzyme engineering has been promoted, making enzyme engineering an important role in bioengineering. In fact, it is an epoch-making leap in human understanding of enzymes, transformation of new enzymes and extensive use of enzymes.
With the great insights on enzyme catalytic mechanisms, biosynthesis, structure, and the rapid development of physical and chemical technology, the rapid rise of molecular enzymology and enzyme engineering has been promoted, making enzyme engineering an important role in bioengineering. In fact, it is an epoch-making leap in human understanding of enzymes, transformation of new enzymes and extensive use of enzymes.   The microbial enzyme source is the main source of enzyme engineering research. Biodiversit…