Articles

As well as an increasing number of opportunities available for jobseekers looking to enter Clinical Research, jobs in this field can be extremely rewarding, albeit challenging. There is huge potential for career development, as well as competitive salaries and job packages on offer for the right candidates. For those looking for their first entry-level role, and those looking to transition into Clinical Research from a related field, we’ve rounded up 8 benefits of working in Clinical Research.
The global clinical trials market size is predicted to hit $84.43 billion by 2030, up from $48.4 billion in 2020. A huge amount of talent is needed to drive this growth, and Clinical Research Organisations (CROs) are having to work harder than ever to engage and retain this talent in a job market that…

With the British Medical Journal revealing that levels of staff burnout within the care sector are still increasing, there has never been a better time to focus on the mental well-being and overall happiness of some of the most hard-working teams in the UK.
Despite these numbers continuing to rise and only 27% of healthcare workers, asked in a 2021 survey, feeling that there are enough members of staff on each ward, there has been very little government support offered.  With this in mind, the patient safety and compliance experts at Radar Healthcare have compiled a list of simple yet effective methods of self-care, in order for healthcare workers to use during times of crisis and help them to successfully switch off after a long shift.  Try to calm your mind after a stressful day. This can…

Bachem, the Swiss pharmaceutical company, invested in a capacity expansion for large-scale production of oligonucleotide active pharmaceutical ingredients (APIs).
Each step within the company’s oligonucleotide manufacturing process uses unique, innovative equipment to deliver the highest-quality products and to increase sustainability. Tailor-made oligonucleotide synthesisers To ensure only the highest-quality oligonucleotide is supplied to customers, Bachem designed a large-scale oligonucleotide synthesiser. This synthesiser optimises the process of oligonucleotide synthesis and has been qualified for GMP batches from a 0.2 mol to 2 mol scale. One of the engineering solutions used for the innovative synthesiser is in-line mixing of dichloroacetic acid (DCA) and toluene. This solution is u…

The world is facing the highest inflation rates in 40 years, and pundits are talking of a possible recession in the coming months. The causes of this are well understood – a combination of factors including a shrinking labour pool, pandemic-related disruptions, global energy shortage, and the current crisis in Ukraine have placed persistent pressure on fragile supply chains, creating the perfect recipe for escalating costs.
The world is facing the highest inflation rates in 40 years, and pundits are talking of a possible recession in the coming months. The causes of this are well understood – a combination of factors including a shrinking labour pool, pandemic-related disruptions, global energy shortage, and the current crisis in Ukraine have placed persistent pressure on fragile supply ch…

Offboarding is the process that takes place when an employee leaves an organisation, whether this is through resignation, termination, or retirement. When an employee leaves, they will either become an advocate for your organisation or an antagonist. How you handle your offboarding process can determine which of these your employees become.
Offboarding is the process that takes place when an employee leaves an organisation, whether this is through resignation, termination, or retirement. When an employee leaves, they will either: Become an advocate for your organisation; leaving positive reviews on sites like Glassdoor, recommending your organisation as a great place to work, and helping you to build a positive employer brand, or Become an antagonist to your organisation; leaving negative…

Completing courses to list on your CV can demonstrate your proactive approach to learning and development as well as your awareness of current industry developments, challenges, and opportunities. It will also allow you to build on your knowledge and skills beyond the roles you’ve held, enabling you to differentiate yourself from applicants with a similar professional background. In this article, we’ve rounded up 24 free Life Science courses for you to complete in 2022.
Regardless of whether you’re looking for your 10th Life Science job or are looking for your first step in the industry, completing courses and workshops in your own time can be a great way of enhancing your CV. Completing courses to list on your CV can demonstrate your proactive approach to learning and development as well a…

Amplexor’s Renato Rjavec describes practical steps to building the skills for a data-driven future.
Most life sciences Regulatory teams still think and work in terms of documents. Yet it is data, rather than pre-prepared dossiers, that is moving into focus and many companies do not have the necessary skills base to handle this. Stakeholders across the life sciences and healthcare ecosystem are increasingly realising that a data-first approach to collecting, managing and communicating product information will be the most efficient and reliable way to maintain consistent, definitive, current and high-quality record of a product entering or on the market. One that can be interpreted and use in a wide range of use cases, by the broadest possible range of people (from regulators to clinicians, p…

The war in Ukraine has shone a spotlight on the reliance of the pharmaceutical sector on certain countries when it comes to manufacturing and drug discovery.
The war in Ukraine has shone a spotlight on the reliance of the pharmaceutical sector on certain countries when it comes to manufacturing and drug discovery. Before the war, Ukraine had around 2,500 clinical trial sites however a number of big pharma organizations including Merck, Abbvie and Sanofi have since halted their studies. Meanwhile, others have announced they have stopped conducting trials in Russia while the war is ongoing, raising further concerns in the industry over the potential consequences for drug development. While the conflict will undoubtedly have an impact, a new report has revealed the countries where the most cl…

SiSaf Ltd, an RNA delivery and therapeutics company, announces that it is initiating the U.S. FDA Regulatory process to obtain an Orphan Drug Designation for SIS-101-ADO, a siRNA therapeutic for patients with Autosomal Dominant Osteopetrosis Type 2 (ADO2), a rare genetic skeletal disorder. The request for Orphan Drug Designation and advancement through the complex regulatory process that SIS-101-ADO must undergo is being coordinated by CSSi LifeSciences, a leader in shepherding emerging therapeutics through federal approval processes.
The SIS-101-ADO combines an siRNA that suppress the expression of CLCN7, with SiSaf’s Bio-Courier® next generation silicon stabilized hybrid lipid nanoparticles (sshLNP) technology that addresses the limitations of other RNA delivery technologies by merging l…

CYP450 has been extensively studied since its discovery was reported in 1962 in the journal JBC, including structural features, catalytic mechanisms, regulation, and many other aspects of biochemistry. Scientists believe that further research and engineering advances on CYP450 will bring great benefits to synthetic biology in the future.
Overview of Cytochrome P450 Cytochrome P450 (CYP450), is a family of hemoglobin-coupled monooxygenases. In mammals, CYP450 oxidizes steroids, fatty acids, and xenobiotics, playing an important role in the metabolism of various compounds as well as in the synthesis and breakdown of hormones. In plants, they regulate the synthesis of defense compounds, fatty acids, and hormones. With the progress of research, the effects of CYP450 on organic synthesis and dru…

Health actors can draw on the contributions of interdisciplinarity, big data and modelling to improve their foresight capacities alongside the public authorities.
The pharmaceutical industries are naturally at the forefront of scientific innovation and emergency treatments, rather than of long-term intelligence and monitoring activities. This is further evidenced by the very short period of time – less than a year – that elapsed between discovery of the first cases of an unknown disease in Wuhan and the roll-out of the large-scale vaccine campaign.  The scope and complexity of prospective phenomena – over and above their scientific and logistical components – requires the pooling of intelligence and anticipation by combining a range of expertise and talent, and this cannot be left to…

A data-first approach to content sharing, using flexible and dynamic data objects, is consigning structured document authoring to history. Generis’ James Kelleher explains how a shift towards real-time data as a single source of truth is fast replacing the traditional structured document authoring approach.
Structured authoring was designed to be the future of document authoring – the ultimate efficiency in presenting information. But a data-driven approach to information sharing is set to address issues with version control and provide a more traceable line back to the master source of intelligence. This does mean that structured document authoring, as a much-anticipated technology proposition, is already obsolete - before it really had a chance to get off the ground. The original concept…

In this article, we outline 10 ways to improve your employer brand using PR and content; from refamiliarizing yourself with the core company values, to tracking the results of your recruitment marketing efforts.
As a Life Science recruiter or hiring manager, employer branding should be at the forefront of all your recruitment marketing activities. You should be working to establish an employer brand that clearly tells jobseekers: Who you are, what you do, and what you stand for What types of people would thrive in the working environment you offer What it’s like to work for your organisation What employees receive when they join you (this is more than the salary and benefits) As PR is all about effective storytelling, raising brand awareness, and influencing perceptions held about an orga…

Circular RNAs are closed-loop single-stranded RNA (ssRNA) that are structurally specific, and produced by the back-splicing process. CircRNAs can exist independently of proteins and are unaffected by exonucleases, and are widely found in plant and animal cells to regulate gene expression.
Circular RNAs are closed-loop single-stranded RNA (ssRNA) that are structurally specific, and produced by the back-splicing process. CircRNAs can exist independently of proteins and are unaffected by exonucleases, and are widely found in plant and animal cells to regulate gene expression.   Circular RNAs were first discovered by Sanger studying virus-like RNAs. And in 1991, Nigro stumbled upon an unusual novel RNA product. The low abundance of circRNA expression and the limitations of detection techno…

Methylation is one of the most classical epigenetic modifications in eukaryotes. DNA methylation regulates gene expression and has important implications in both growth and disease-related research. DNA methylation affects the maturation of germ cells or embryonic cells subject to specific gene expression. It has also been widely studied and applied to track aging and various forms of human disease. Various diseases, especially cancer have a pattern of DNA methylation that is not present in normal cells, resulting in differences in gene expression levels.
Methylation is one of the most classical epigenetic modifications in eukaryotes. DNA methylation regulates gene expression and has important implications in both growth and disease-related research. DNA methylation affects the maturation o…

Currently, the incidence of infectious diseases has increased globally, and the pathogens show a trend of diversification and complexity. Rapid and accurate pathogenic diagnosis, which enables early selection of sensitive anti-infective drugs or effective and targeted preventive and control measures, is the core of accurate prevention and treatment of infectious diseases. The epidemic of respiratory pathogens has been bringing a huge disease burden to human beings, as in the case of the global pandemic of novel coronavirus (SARS-CoV-2), which has seriously affected world health and economic development.
Currently, the incidence of infectious diseases has increased globally, and the pathogens show a trend of diversification and complexity. Rapid and accurate pathogenic diagnosis, which enabl…

Life sciences companies are increasingly looking to the next step in regulatory information management modernisation. The focus is now on enabling smarter end to end process management while enhancing data flow with the wider enterprise. Drawing on his company’s 2022 World Class RIM Survey, Gens & Associates founder Steve Gens reveals the plans and ambitions for world-class RIM .
A decade since we started tracking their ambitions for improving regulatory information management (RIM), life science regulatory operations have achieved much in modernizing the immediate function globally and improving general efficiency. They have also deepened the strategic partnership with other functions such as clinical, quality, and manufacturing - to improve regulatory pathways/expedite new product approva…

A data-first approach to content sharing, using flexible and dynamic data objects, is consigning structured document authoring to history. Generis’ James Kelleher explains how a shift towards real-time data as a single source of truth is fast replacing the traditional structured document authoring approach.
Structured authoring was designed to be the future of document authoring – the ultimate efficiency in presenting information. But a data-driven approach to information sharing is set to address issues with version control and provide a more traceable line back to the master source of intelligence. This does mean that structured document authoring, as a much-anticipated technology proposition, is already obsolete - before it really had a chance to get off the ground. The original concept…

Health actors can draw on the contributions of interdisciplinarity, big data and modelling to improve their foresight capacities alongside the public authorities.
The pharmaceutical industries are naturally at the forefront of scientific innovation and emergency treatments, rather than of long-term intelligence and monitoring activities. This is further evidenced by the very short period of time – less than a year – that elapsed between discovery of the first cases of an unknown disease in Wuhan and the roll-out of the large-scale vaccine campaign.  The scope and complexity of prospective phenomena – over and above their scientific and logistical components – requires the pooling of intelligence and anticipation by combining a range of expertise and talent, and this cannot be left to…

The COVID-19 pandemic has brought an increased focus on where the next serious infectious disease might originate. Stakeholders from across the industry, including biopharmaceutical companies, governments, and non-profit organizations, are rethinking their pandemic readiness, and there is a new focus on the next potential threat of a highly pathogenic new virus or Disease X.1
The COVID-19 pandemic has brought an increased focus on where the next serious infectious disease might originate. Stakeholders from across the industry, including biopharmaceutical companies, governments, and non-profit organizations, are rethinking their pandemic readiness, and there is a new focus on the next potential threat of a highly pathogenic new virus or Disease X.1 If, or when, the next pandemic arises from…