Articles

Provided to more than a quarter of cancer patients, today’s targeted radiotherapy has come a long way from its experimental, and Nobel Prize winning, origins. When administering the treatment, shaping of the beam is an important way of minimising the absorbed radiation in healthy tissue and delivering an accurate dose. Here, Stewart Goulding, managing director of high torque DC motor supplier Electro Mechanical Systems explains how multileaf collimators (MLC) deliver accuracy in radiotherapy.
Provided to more than a quarter of cancer patients, today’s targeted radiotherapy has come a long way from its experimental, and Nobel Prize winning, origins. When administering the treatment, shaping of the beam is an important way of minimising the absorbed radiation in healthy tissue and delivering…

Due to their special energy level structure, quantum dots exhibit unique physical properties. This article mainly discusses some properties of quantum dots, including quantum confinement effect, quantum size effect, surface effect and luminescence property.
Quantum dots, also known as semiconductor nanocrystals, are nanoscale materials composed of a small number of atoms. The number of atoms in a quantum dot is usually between a few and a few hundred, and their size in all three dimensions are less than 100 nm. The movement of carriers in the three dimensions of quantum dots is limited by the size effect. Due to the quantum confinement effect, the energy levels of carriers in quantum dots are similar to those of atoms having a discontinuous energy level structure, so quantum dots are also c…

In the drug company trade, with more uncertainties from the method of a research project, project management becomes tougher.
In the drug company trade, with more uncertainties from the method of a research project, project management becomes tougher. Project management within the pharmaceutical trade involves: Scope management Project coming up with, executing, and watching Timeline and budget coming up with and management Stakeholder management Management of regulative and compliance ways Environmental safety Risk management Team management Challenges underlie each of those aspects of project management. The interdependencies between these components create even additional advanced. Whereas the developed product is also effective for the supposed use, it's going to need dangerous chemi…

As the life science industry continues to embrace more flexible ways of working, you may find yourself managing a team of hybrid or remote workers. As hybrid and remote working come with their own set of both challenges and opportunities, these ways of working also require a very different managerial approach.
As the life science industry continues to embrace more flexible ways of working, you may find yourself managing a team of hybrid or remote workers. As hybrid and remote working come with their own set of both challenges and opportunities, these ways of working also require a very different managerial approach. We’ve put together this list of 14 best practices when it comes to managing your remote pharma employees, from retraining to recognising signs of burnout… Provide Training on Ke…

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Pathology laboratories are vital in any medical practice as a unique medical field establishment. However, this kind of establishment can vary in iterations and size and, at times, can be part of the hospital. Most laboratories are established near hospitals or medical practice facilities, given the work it does. While hospital labs generate only 3 to 5 percent of hospital revenue, their findings make 70 to 80 percent of a patient’s electronic health record (EHR). Furthermore, CDC estimated that almost 70 percent of doctors’ medical decisions are based on lab test results. This means careful att…

Whilst your CV tells recruiters and hiring managers how qualified you are for a role on paper, your job interview gives you an opportunity to sell your suitability for the role and set yourself apart from equally qualified peers. To help with your pharma job search, we’ve put together these 13 tips to help you make your job interview one to remember, from how to prepare for your interview to creating your post-interview routine.
Whilst your CV tells recruiters and hiring managers how qualified you are for a role on paper, your job interview gives you an opportunity to sell your suitability for the role and set yourself apart from equally qualified peers. To help with your pharma job search, we’ve put together these 13 tips to help you make your job interview one to remember, from how to pre…

The novel DUBTAC therapeutic platform enables the development of novel drugs against a wide range of human diseases, including cancer and neurodegenerative diseases as well as a variety of inherited diseases, by targeting abnormally degraded pathogenic proteins previously thought to be untargeted.
The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered “undruggable”, and several projects have entered clinical evaluation worldwide.   Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer. Therefore, for these diseases, targeted protein stabilizers (TPS), rather than targeted protein degraders (TP…

Staining is one of the most important steps in the preparation of biological microscope slides. First destroy the selective permeability of the cell membrane, and then use the dye to immerse the biological tissue in the dye, so that a certain part of the tissue cells is dyed with a different color or depth of color from other parts, resulting in different refractive indices for observation.
Staining is one of the most important steps in the preparation of biological microscope slides. First destroy the selective permeability of the cell membrane, and then use the dye to immerse the biological tissue in the dye, so that a certain part of the tissue cells is dyed with a different color or depth of color from other parts, resulting in different refractive indices for observation. Commonly used…

Among the endoproteases used for protein digestion, serine protease trypsin is the most common one, as it generates peptides that are highly amenable to MS analysis. Depending on the preceding workflow, the enzymatic digestion of proteins is performed either in-gel or in-solution. Generally, the in-gel digestion methodology has become routine for proteins separated by 2-D electrophoresis while in-solution digestion is usually used in LC-MS/MS analysis. The protein is cut enzymatically into a limited number of shorter fragments, or peptides, during digestion to allow for the identification of the protein with its characteristic mass and pattern.
Among the endoproteases used for protein digestion, serine protease trypsin is the most common one, as it generates peptides that are highly amenabl…

Pehr Edman published a protein sequencing method, Edman Degradation, in 1950. This method made it possible to determine the extended sequences of peptides or whole proteins and is widely used today. The method removes and identifies amino acid residues at the end of the peptide chain, i.e. residues with free α-amino groups, through a series of chemical reactions. At the same time, the next residue in the sequence is made and subjected to the same round of chemical reactions. Repeating this process reveals the sequence of the polypeptide. This method is a powerful tool for proteomics studies.
Pehr Edman published a protein sequencing method, Edman Degradation, in 1950. This method made it possible to determine the extended sequences of peptides or whole proteins and is widely used today…

Edman degradation sequencing is to sequentially cut out each amino acid at the N-terminal of the protein through chemical reaction and then use HPLC liquid chromatography to identify the ID of the amino acid, and the obtained amino acid sequence information is the sequence of the N-terminal of the protein. Next, we use the determination of the first amino acid at the N-terminus of a protein as an example to explain the entire process of a single Edman sequencing reaction.
What is Edman Degradation Sequencing? Edman degradation sequencing is to sequentially cut out each amino acid at the N-terminal of the protein through chemical reaction and then use HPLC liquid chromatography to identify the ID of the amino acid, and the obtained amino acid sequence information is the sequence of the N-ter…

Protein research is one of the most challenging topics in analytical chemistry. Initial protein research focused on developing techniques capable of isolating and identifying major sequences (or portions) of proteins.
Protein research is one of the most challenging topics in analytical chemistry. Initial protein research focused on developing techniques capable of isolating and identifying major sequences (or portions) of proteins. Edman degradation of peptide is a revolutionary method to identify the main amino acid sequence of peptide. In addition, the whole sequence of proteins can be determined by combining protein digestion with different enzymes, fractionation of peptides by high performance liquid chromatography (HPLC), and then Edman degradation. In the 1990s, protein identification…

Even before the current cost of living crisis, one in eight UK workers already lived in poverty. With 16% of businesses not taking any measures to help staff with the rising cost of living, there is much more to be done to support employees – and you don’t need the biggest budget to do this. In this article, we highlight 11 ways to support employees with the rising cost of living, helping you to maintain a happy, healthy, and productive workforce.
A report by Totaljobs found that in the UK, 47% of workers are living ‘payslip to payslip’, with 36% saying their current salary doesn’t enable them to have a good quality of life. Despite inflation reaching a 40-year high, the report also found that of the 58% of employers who were able to increase their employees’ salaries over the last year, 35…

Keratinase is an extracellular protein hydrolysis inducing enzyme that degrades insoluble keratin substrates. This enzyme can hydrolyze hair, feathers and collagen in wastewater systems during wastewater treatment. In addition, it can be used in the food industry and in the manufacture of livestock feed, among others.
Keratinase is an extracellular protein hydrolysis inducing enzyme that degrades insoluble keratin substrates. This enzyme can hydrolyze hair, feathers and collagen in wastewater systems during wastewater treatment. In addition, it can be used in the food industry and in the manufacture of livestock feed, among others.   Keratinase is an adaptogenic enzyme that is produced only when an inducer (keratin) is introduced into the microenvironment. Keratinase is extracted from…

Enzymes are a class of biological catalysts. They govern many catalytic processes such as metabolism, nutrition, and energy conversion of organisms. Most of the reactions closely related to life processes are enzyme-catalyzed reactions. These properties of the enzyme enable the intricate process of material metabolism in the cell to proceed in an orderly manner, and to adapt material metabolism to normal physiological functions.
Catalysis Enzymes are a class of biological catalysts. They govern many catalytic processes such as metabolism, nutrition, and energy conversion of organisms. Most of the reactions closely related to life processes are enzyme-catalyzed reactions. These properties of the enzyme enable the intricate process of material metabolism in the cell to proceed in an orderly…

Bacterial plasmids are circular or linear double-stranded DNA molecules defined by their capability of autonomous replication in the hosts. They are critical sources for microbial evolution and genome innovation due to their ability to acquire foreign DNA sequences and transfer among bacteria and between distantly related organisms, like transferring from bacteria to eukaryotes via conjugation and mobilization.
Bacterial plasmids Bacterial plasmids are circular or linear double-stranded DNA molecules defined by their capability of autonomous replication in the hosts. They are critical sources for microbial evolution and genome innovation due to their ability to acquire foreign DNA sequences and transfer among bacteria and between distantly related organisms, like transferring from bacteria…

Dual RNA sequencing is one of the novel RNA-seq technologies. It shines a light on the simultaneous transcriptomics in host-pathogen interactions and is particularly suitable for investigating the molecular mechanisms of hosts and pathogens interactions. Dual RNA-seq does not require predesigned species-specific probes and allows the detection of transcripts with low abundances in a sensitive manner.
What is dual RNA sequencing? Understanding how pathogen induces disease requires the knowledge on which genes are expressed and how they are regulated during infection. RNA sequencing has been routinely used to analyze the gene expression of microbial pathogens. Apart from the standard mRNA sequencing, new methods are surging based on RNA-seq, mapping the post-transcriptional networks control…

Bioinformatics is a discipline developed on the basis of biology, mathematics and computer science. It effectively acquires and analyzes biological data such as nucleic acid sequences and protein structures, so as to conduct comprehensive and accurate biological analysis. Bioinformatics is an extremely important tool to study the microorganisms, which are widespread and highly varied.
Bioinformatics is a discipline developed on the basis of biology, mathematics and computer science. It effectively acquires and analyzes biological data such as nucleic acid sequences and protein structures, so as to conduct comprehensive and accurate biological analysis. Bioinformatics is an extremely important tool to study the microorganisms, which are widespread and highly varied.   Bioinformatics in…

Nano-materials, which made of silicon, gallium arsenide and other semiconductor materials, possess many excellent properties.
Nano-magnetic materials In practice, most of the nanomaterials are artificial. Magnetic nano-materials made up of small-sized nano-particles and single-domain structures, so they have very special magnetic properties and high coercivity properties. Recording materials that made up of magnetic nanomaterials are not only possess good sound, image quality, and high SNR(signal to noise ratio), but also have several times recording density of?-Fe2O3. Superparamagnetic ferromagnetic nanoparticles can also be made into magnetic fluids for electroacoustic devices, damping devices, rotary seals, lubrication and beneficiation fields. Nano-ceramic materials Traditional ceramic…

A survey of European and US pharma companies’ initial experiences of the EMA’s centralised clinical trials information system (CTIS) has revealed high levels of adoption and widespread recognition of the benefits, according to Arriello’s Kieran O’Donnell and Nicola Kidman.
In the late summer, Arriello commissioned a comprehensive survey of European and US pharma companies’ initial experiences of the EMA’s new centralised clinical trials information system (CTIS). The new platform and portal are designed to streamline the submission, assessment and approval of trials across EU markets, under the new Clinical Trials Regulation (CTR)[1], applicable since the end of January 2022 and mandatory for all new trials from January 31, 2023. Expectations for the new system have been high - if tentative…