Articles

Whole genome sequencing (WGS) has the capacity to greatly enhance genomic knowledge and understand mysteries of life by utilizing the most advanced genetic sequencing technologies. WGS can be used for variant calling, genome annotation, phylogenetic analysis, reference genome construction, and more. WGS tries to cover the whole genome, but actually covers 95% of the genome with technical difficulties in sequencing regions such as centromeres and telomeres. Another challenge for WGS is data management. As larger datasets become more accessible and affordable, computational analysis will be the rate-limiting factor rather than sequencing technology. Here we will discuss the bioinformatics workflow for detection of genetic variations in WGS to help you get through it.
Whole genome sequencing (…

Working in the life science industry can be extremely rewarding, with a unique opportunity to save lives and improve the quality of life for patients across the globe. Whether you see yourself working in a laboratory researching molecules for use in drug development, or in an office processing contracts and other legal documents to kickstart a clinical trial, the work you do in the industry has a real, meaningful impact on people’s lives worldwide.
Working in the life science industry can be extremely rewarding, with a unique opportunity to save lives and improve the quality of life for patients across the globe. Whether you see yourself working in a laboratory researching molecules for use in drug development, or in an office processing contracts and other legal documents to kickstart a cl…

In order to attract top talent in the life science industry, you need to ensure you’re providing the best possible experience for your candidates, from the minute you post a job advert to the moment they’re offered the job, and even beyond. 7 in 10 jobseekers who receive a poor candidate experience will never want to work for that organisation again, with 72% also saying that they’d be likely to tell friends, colleagues, and family members about the experience.
In order to attract top talent in the life science industry, you need to ensure you’re providing the best possible experience for your candidates, from the minute you post a job advert to the moment they’re offered the job, and even beyond. 7 in 10 jobseekers who receive a poor candidate experience will never want to work for that or…

When searching for your next life science job, it’s important to remember that there’s more to a job than a salary. When deciding whether or not to accept a job offer, you need to consider the entire job package, including things like company culture and career progression as well as the salary and benefits on offer.
When searching for your next life science job, it’s important to remember that there’s more to a job than a salary. When deciding whether or not to accept a job offer, you need to consider the entire job package, including things like company culture and career progression as well as the salary and benefits on offer. In this article, we’ve highlighted 9 reasons you might want to turn down a job offer, with advice on steps you can take before turning it down. The Salary Isn’t Hi…

Chronic Obstructive Pulmonary Disease, or COPD, has been branded as the "silent killer." It is because some people do not even know they have it until it becomes too dangerous to handle. Millions of people in the United States have COPD but have not been diagnosed because they are unaware of it. This implies that they also do not get treatment for it. This is when the disease becomes a threat to life. Let us first learn more about COPD.
Chronic Obstructive Pulmonary Disease, or COPD, has been branded as the "silent killer." It is because some people do not even know they have it until it becomes too dangerous to handle. Millions of people in the United States have COPD but have not been diagnosed because they are unaware of it. This implies that they also do not get treatment for it. This i…

Carbon nanomaterials have been speedily developed due to their unique electronic, optical, thermal, mechanical, and chemical nature.
History of Development As early as 1985, the discovery of fullerene with the “football” structure immediately attracted the world’s attention. Then, carbon nanotubes with a hollow cylindrical structure are formed based on mild modifications toward fullerenes. In 1991, Japanese researchers discovered carbon nanotubes in carbon fibers for the first time. In 2004, researchers discovered the 2D planar nanomaterial whose planar thickness is confined to the nanoscale range. At the same time, researchers also developed a practical “scotch tape” technique to separate single-layer graphene from bulk graphene. Buckyballs (fullerenes), carbon nanotubes, and graphene all…

To attract the best talent in the life science industry, you need to ensure that you’re not only providing people with a job that will pay the bills, but also a unique company culture and a superior employee experience. In other words, you need to position your organisation as an employer of choice.
To attract the best talent in the life science industry, you need to ensure that you’re not only providing people with a job that will pay the bills, but also a unique company culture and a superior employee experience. In other words, you need to position your organisation as an employer of choice. To attract top talent, you need to present your organisation as a top employer, showing jobseekers exactly what they will gain through working for you beyond a salary. This article looks at 9 things…

Clinical Research Associates (CRA) are responsible for organising and monitoring clinical trials, helping to identify the benefits and risks of new and pre-existing drugs, ensuring they’re effective and safe for their intended use. CRAs are often involved in all stages of a clinical trial, from identifying a relevant investigational site and setting up the trial, to closing down the trial and preparing final reports.
Clinical Research Associates (CRA) are responsible for organising and monitoring clinical trials, helping to identify the benefits and risks of new and pre-existing drugs, ensuring they’re effective and safe for their intended use. CRAs are often involved in all stages of a clinical trial, from identifying a relevant investigational site and setting up the trial, to closing dow…

Bachem is a leading, innovation-driven company specialising in the development and manufacture of peptides and oligonucleotides. With 50 years of experience, Bachem provides products for research, clinical development and commercial application to pharmaceutical and biotechnology companies worldwide and offers a comprehensive range of services. Bachem operates internationally, with headquarters in Switzerland and locations in Europe, the US and Asia. The company is listed on the SIX Swiss Exchange.
Oligonucleotides are short, single or double-stranded fragments of DNA or RNA that can be used for therapeutic purposes. Originally, there was an emphasis on using this new drug modality for treating rare diseases, yet they have also shown great potential to be used for more common diseases. …

ICH Q3D presents major challenges to testing and risk assessments associated with meeting current rigorous limits for specific components to assess patient risk. The probability that sure elemental impurities area unit gift in a very healthful product ought to be determined through a legitimate risk assessment.
The mission of the International Council for Harmonisation of Technical needs for prescription drugs for Human Use (ICH) is to make sure safe, effective, and high-quality medicines area units are developed and distributed. This is often accomplished by making worldwide harmonization. Harmonization achievements within the quality space include: Essential milestones like the conduct of stability studies Process relevant thresholds for impurities testing A lot of versatile approaches t…

The biotech industry is a large and growing field with many opportunities for those who want to pursue it professionally. The growth of this industry has been rapid in recent years, with more than 200 new products being marketed every year. In this article, we will look at the current trends in the industry and discuss how they affect marketers and consumers.
What is Biotechnology? Biotechnology is the application of biological processes and materials, including biochemistry, microbiology and molecular biology. Nobel-prize-winning chemist George Wald coined the term in 1949. Biotechnology is not the same as traditional biochemistry: it encompasses a diverse range of techniques we can use for industrial processing and research purposes. For example, it includes processes such as recombin…

Lung cancer is a major type of cancer in the world, with the highest morbidity and mortality among all malignant tumors. ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases.
Lung cancer is a major type of cancer in the world, with the highest morbidity and mortality among all malignant tumors. ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases. Statistics show that about 55% of ALK-positive advanced NSCLC patients will develop brain metastases during the treatment process, which is a serious challenge facing oncologists. In recent years, the application of targe…

Protein identification here refers to the accurate screening and identification of proteins using certain biochemical and physical methods. Traditional protein identification methods, including immunoblotting, comigration analysis of known or unknown proteins, and chemical sequencing of endopeptides, are complicated, time-consuming, and less accurate.
Methods in protein identification Protein identification here refers to the accurate screening and identification of proteins using certain biochemical and physical methods. Traditional protein identification methods, including immunoblotting, comigration analysis of known or unknown proteins, and chemical sequencing of endopeptides, are complicated, time-consuming, and less accurate.   Protein identification methods have evolved fro…

16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms.
16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms. 16S/18S/ITS amplicon sequencing reveals the species of microorganisms in environmental samples and their differences, relative abundance, population structure and evolutionary relationships. It plays an important role in the research of microorganisms and human health, agriculture and animal husbandry, environmental detection and t…

16S/18S/ITS amplification sequencing uses the next/third generation sequencing platform and performs high throughput sequencing of PCR products from specific regions such as 16S rDNA/18S rDNA/ITS/ functional genes. It overcomes the disadvantage of some microorganisms that is difficult or impossible to culture, and obtains the information of microbial community structure, evolutionary relationships and microbial correlation with environment in environmental samples.
16S/18S/ITS amplification sequencing uses the next/third generation sequencing platform and performs high throughput sequencing of PCR products from specific regions such as 16S rDNA/18S rDNA/ITS/ functional genes. It overcomes the disadvantage of some microorganisms that is difficult or impossible to culture, and obtains the inf…

Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. Sequencing the entire microbial genome is important for construction of accurate reference genomes, microbial identification, and other comparative genomic studies.
Microorganisms widely exist in nature and are closely related to human life and production. They are generally divided into fungi, actinomycetes, bacteria, spirulina, rickettsia, chlamydia, mycoplasma and viruses. Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. Sequencing the entire microbial genome is important f…

Metatranscriptomic sequencing provides direct access to culturable and non-culturable microbial transcriptome information by large-scale, high-throughput sequencing of transcripts from all microbial communities in specific environmental samples. Metatranscriptomic sequencing offers an opportunity to randomly sequence mRNAs as a unit for understanding the regulation of complex processes in microbial communities.
What is metatranscriptomic sequencing? Metatranscriptomic sequencing provides direct access to culturable and non-culturable microbial transcriptome information by large-scale, high-throughput sequencing of transcripts from all microbial communities in specific environmental samples. Metatranscriptomic sequencing offers an opportunity to randomly sequence mRNAs as a unit fo…

As a biocatalyst, enzyme has been widely used in various production fields of light industry. In recent decades, with the continuous technological breakthroughs in enzyme engineering, it has become more and more widely used in industry, agriculture, medicine and health, energy development and environmental engineering.
As a biocatalyst, enzyme has been widely used in various production fields of light industry. In recent decades, with the continuous technological breakthroughs in enzyme engineering, it has become more and more widely used in industry, agriculture, medicine and health, energy development and environmental engineering.   Food processing applications   The biggest use of enzymes in the food industry is starch processing, followed by dairy processing, fruit juice proc…

In the early 20th century, humans discovered vitamins, and then trace elements and minerals. It was only in the mid-1980s that humans realized the importance of enzymes. Nobel Prize in Physiology and Medicine Arthur Kornberg said: "For our lives, we can no longer find other substances as important as enzymes in nature." Enzymes control the entire body, and when enzymes function abnormally is fatal to human.
In the early 20th century, humans discovered vitamins, and then trace elements and minerals. It was only in the mid-1980s that humans realized the importance of enzymes. Nobel Prize in Physiology and Medicine Arthur Kornberg said: "For our lives, we can no longer find other substances as important as enzymes in nature." Enzymes control the entire body, and when enzymes function abnormall…

With the continuous development of science and technology, the ability and scope of human development and utilization of natural resources are expanding, and the ensuing environmental pollution problems are becoming more and more serious. Environmental pollution has become an important factor restricting the development of human society. Therefore, environmental protection issues have received increasing attention. Traditional techniques for solving environmental pollution have become increasingly insufficient to cope with the increasingly serious environmental problems, and there is an urgent need to find a new method that is faster and more efficient to solve environmental problems.
With the continuous development of science and technology, the ability and scope of human development and u…