Articles

The spotlight is on data as it becomes increasingly central to Life Sciences processes. Deloitte’s Patrick Middag and Dennie van de Voort set out recommendations for developing and embedding an effective enterprise data governance strategy.
The impact of any digital process transformation program relies heavily on the quality and reliability of the data that feeds into those processes. If that data is patchy, inconsistent, out of date, or incorrect, risks will be magnified each time someone re-uses that data. Operationally, inconsistent information exchanged with the regulators will lead to non-compliance risks, risks of poor quality and ultimately patient safety and public health risks. More strategically, it will limit companies’ ability to perform useful data analytics and to increase th…

De novo sequencing is a method to analyze and identify peptide sequences and some post-translational modified proteins. Different from some other analysis methods, which depend on a known protein sequence database or a known mass spectrometry database, de novo sequencing uses tandem mass spectrometry for direct analysis based on the fragmentation characteristics of the peptide.
The method of peptide and protein de novo sequencing by mass spectrometry De novo sequencing is a method to analyze and identify peptide sequences and some post-translational modified proteins. Different from some other analysis methods, which depend on a known protein sequence database or a known mass spectrometry database, de novo sequencing uses tandem mass spectrometry for direct analysis based on the fragm…

Gas chromatography is a chromatographic method that uses gas as a mobile phase. The sample flows through the gas system and is gasified before finally entering a chromatographic column filled with a filler to achieve effective separation. Gas chromatography has the advantages of high sensitivity, small sample usage, strong separation ability, good selectivity, wide application, and fast analysis.
  What is gas chromatography and liquid chromatography? Gas chromatography is a chromatographic method that uses gas as a mobile phase. The sample flows through the gas system and is gasified before finally entering a chromatographic column filled with a filler to achieve effective separation. Gas chromatography has the advantages of high sensitivity, small sample usage, strong separation…

The most common endoprotease used for protein digestion is serine protease trypsin, which produces peptides that are highly amenable to MS/MS analysis. Depending on the preceding workflow, the enzymatic digestion of proteins is performed either in-gel or in-solution. Generally, the in-gel digestion methodology has become routine for proteins separated by 2-D electrophoresis while in-solution digestion is usually used in LC-MS/MS analysis. The protein is cut enzymatically into a limited number of shorter fragments, or peptides, during digestion to allow for the identification of the protein with its characteristic mass and pattern.
The most common endoprotease used for protein digestion is serine protease trypsin, which produces peptides that are highly amenable to MS/MS analysis. Depending…

This article provides a brief introduction to good practices for the bioinformatics analysis of 16S rRNA sequencing by NGS (next-generation sequencing). The bioinformatics pipeline involves two main stages: the preprocessing of data (quality control) and quantification (including taxonomic profiling and predictive metagenomics profiling).
This article provides a brief introduction to good practices for the bioinformatics analysis of 16S rRNA sequencing by NGS (next-generation sequencing). The bioinformatics pipeline involves two main stages: the preprocessing of data (quality control) and quantification (including taxonomic profiling and predictive metagenomics profiling).   Preprocessing to eliminate uninformative data Removal of adapters, PCR primers, and low quality bases is a neces…

Metagenomics presents a powerful tool to study prokaryotes and viruses in the environment via the analysis of their DNA obtained directly from environmental samples. This technology considers the DNA of microbes in a population as a whole.
Microbes are present almost everywhere. They play a vital role in cycling carbon, release important compounds, and may be associated with infectious diseases. Metagenomics is the culture-independent genomic research of microbial communities. Metagenomics presents a powerful tool to study prokaryotes and viruses in the environment via the analysis of their DNA obtained directly from environmental samples. This technology considers the DNA of microbes in a population as a whole. It can not only identify the microbial species present but also prov…

With the NHS under immense pressure and pharmacies increasingly under the spotlight, digital solutions can help them adapt to best serve patients.
Stories of NHS waiting lists and a shortage of GPs are becoming all too common headlines in the British press, with pharmacies often pointed towards as a solution to ease the stress felt deeply in the healthcare sector.   However, pharmacies have their own set of pressures to contend with. Indeed, between 2015 and 2022, some 40% community pharmacies closed in 20% of the most deprived areas of England[1], with a recent study revealing that over 90% of pharmacies are experiencing staff shortages.[2]     With recently reappointed health secretary Steve Barclay just this month stating that he is looking at how England can progress ‘Pha…

Photosensitive resins, as a type of photosensitive materials, are widely used in medical, construction, printing, 3D printing and other industries due to their fast curing time and low pollution.
Photosensitive materials are made up of polymers that can undergo rapid physical and chemical changes in a relatively short period of time after being irradiated by light. Photosensitive materials are advanced by high production efficiency, high energy utilization rate, low organic volatile matter emission, and enhanced flexibility in coating various substrates, such as paper, plastic, leather, metal, glass, and ceramics. What are the uses of photosensitive materials? Photosensitive resins, as a type of photosensitive materials, are widely used in medical, co…

Data science essentially offers us a way to make sense of enormous quantities of data. Where the human brain is limited in the amount of complex data it is capable of analyzing, algorithms open a new path forward. In the earliest stages of drug discovery – where molecules are screened and optimized to impact a specific cellular, disease-causing target – data science makes a decisive difference. “Data science allows us to discover patterns and identify new hypotheses that a human wouldn’t necessarily make,” says Christine Durinx, managing director of the world-class research institute VIB.
Data science in early drug discovery – getting it right from the start A quicker path to better medicine Data science essentially offers us a way to make sense of enormous quantities of data. Where the hum…

At work, less than 18% of people use a time management system, and 1 in 8 never feel in control of their work. With the Life Science industry demanding more from recruiters and hiring managers every day, now is the time to review how your time is currently being spent, and implement new techniques to help you stay productive and motivated at work.
At work, less than 18% of people use a time management system, and 1 in 8 never feel in control of their work. With the Life Science industry demanding more from recruiters and hiring managers every day, now is the time to review how your time is currently being spent, and implement new techniques to help you stay productive and motivated at work. In this article, we’ve outlined 10 time management tips for Life Science recruiters, helping you to m…

“This technology is new and very unique. It has the potential to treat tumors which do not respond to the current standard of care such as radiotherapy, chemotherapy, or even the currently available non-personalized immunotherapies,” says Lien Lybaert (CEO a.i., Persomed). But how does this vaccine work? It is a complicated process based on cell therapy;
New personalized cancer vaccine in the making thanks to unique Belgian collaboration Boosting the immune system of patients to fight cancer “This technology is new and very unique. It has the potential to treat tumors which do not respond to the current standard of care such as radiotherapy, chemotherapy, or even the currently available non-personalized immunotherapies,” says Lien Lybaert (CEO a.i., Persomed). But how does this vaccine work…

The COVID-19 pandemic has brought vaccines back into the drug development spotlight, and mRNA vaccines are stealing the show with sales of USD 54.4 billion in 2021 alone. Few know that the developers of the mRNA COVID-19 vaccines actually drew upon years of experience attempting to develop cancer vaccines. This approach goes back several decades, and although the field has to date seen limited success, it has nevertheless witnessed a renewed interests in recent years. We examine the latest trends in cancer vaccine development, and where the opportunities lie for the future of the industry.
Cancer vaccines: not only treating tumors, but preventing them too The COVID-19 pandemic has brought vaccines back into the drug development spotlight, and mRNA vaccines are stealing the show with sales o…

Customize your strategies to target and convert 91.7k prospects using our latest medical device distributors email list
So, you've come up with the perfect idea for a medical device but aren't sure how to go about marketing and selling it? You're not alone! In fact, developing the perfect marketing strategy and sales plan can be tricky since there are so many different factors to consider when you're trying to sell medical devices. 1) Know your audience The audience for medical device marketing is ever-changing. To create the perfect plan, you need to know who you are targeting. This could be different segments of the market or specific parts of the product offering. For instance, if you want to get your product into hospitals, then your target audience would be hospital executives, clinici…

These experiences and lessons for the sensor based on biological engineering, such as molecular probes or the design of gene encoding vectors emerging diagnosis provides the basis for the sensors using the imbalance characteristics of the early tumor or its precursor, generate a signal amplification, these exogenous sensors using tumor dependency activation mechanism, such as enzyme amplification, to drive the synthesis of biomarkers and magnified. Cancer can also be detected by imaging systems that may have the essential features of synthetic biomarker approaches, such as reporter gene imaging. These emerging technologies have promoted the development of early cancer detection, and synthetic biomarkers may become the future method of early cancer detection.
Introduction   Early detect…

More than two decades after the discovery of RNAi, siRNA drugs have opened new avenues for innovative therapies for many diseases. Although there are several significant challenges and limitations, including siRNA delivery and side effects, that have slowed the clinical translation of this novel class of pharmacological compounds, several siRNA drugs have been approved for clinical use and several more are in late-stage clinical studies. siRNA targeting any target gene also highlights the need to identify the best target.
The concept of RNA interference (RNAi) was raised in 1998 and is a naturally occurring defense mechanism against exogenous nucleic acid invasion and control of gene expression. Soon thereafter, small interfering RNAs (siRNAs) were identified as mediators of RNAi in ma…

Fluorescent labeling is the process of covalently attaching fluorescent groups to molecules such as proteins and nucleic acids. Such processes are typically accomplished using derivatives of the fluorescein group that is capable of selectively reacting with functional groups present on the target molecule.
Fluorescent labeling is the process of covalently attaching fluorescent groups to molecules such as proteins and nucleic acids. Such processes are typically accomplished using derivatives of the fluorescein group that is capable of selectively reacting with functional groups present on the target molecule. The most common labeled molecules are antibodies, and labeled antibodies are often used to detect specific target molecules. Fluorescent labels can be used in a variety of detection sys…

Since 2020, market disruption created by COVID-19 has primed every aspect of the pharma industry for change: something that they have been reluctant to do in the decades previous. Today, with more crises potentially awaiting around the corner, there is an openness across the pharmaceutical world to embrace new technologies with a sense of urgency. Here are five important ways technology and automation can support pharma companies with mitigating increased complexity and seizing opportunities.
Since 2020, market disruption created by COVID-19 has primed every aspect of the pharma industry for change: something that they have been reluctant to do in the decades previous. . Today, with more crises potentially awaiting around the corner, there is an openness across the pharmaceutical world to e…

Mobile medical applications development is a vibrant health IT field. According to Grand View Research, the mHealth market will see incremental growth at a CAGR of 11.8% from 2022 to 2030. Is it the right time to start and run such a project?
Carried away by the scope of work or its complexity, mHealth developers can lose track or miss some valuable steps. Here are some tips from a medical app development company.  Pre-project planning A mobile health app project could be challenging and require careful preparation. The work involves three main steps: Conducting a large-scale research Before launching a project, you should assess the market and the dominant health IT trends. It also makes sense to study potential user needs and competitor offers. You could estimate how well top existin…

Research by Pharmaceutical Technology found that in the 2021-2022 reporting year, 95.7% of pharmaceutical companies with a headcount above 250 pay their male employees higher than their female employees. The same research found that across the pharmaceutical industry, median hourly pay was 10% higher for males than females, placing the industry below the UK average of 11.6%.
Research by Pharmaceutical Technology found that in the 2021-2022 reporting year, 95.7% of pharmaceutical companies with a headcount above 250 pay their male employees higher than their female employees. The same research found that across the pharmaceutical industry, median hourly pay was 10% higher for males than females, placing the industry below the UK average of 11.6%. Whilst this doesn’t always mean that males ar…

The healthcare industry is witnessing a significant evolution over the years with biopreservation being the need of the hour. Biopreservation techniques are well-known to maintain the functionality and integrity of regenerative medicines, that come handy in the biopharmaceutical industry for study of different disease treatments.
3 Factors Supporting the Increasing Demand For Biopreservation   The healthcare industry is witnessing a significant evolution over the years with biopreservation being the need of the hour. Biopreservation techniques are well-known to maintain the functionality and integrity of regenerative medicines, that come handy in the biopharmaceutical industry for study of different disease treatments.   It should be noted that the growing prevalence of chronic…