Biotech - Articles

Charnwood Molecular, a leading UK-based pre-clinical discovery CRO servicing the global pharmaceutical and biotechnology market, is pleased to announce the acquisition of the assay development and biological screening provider, Aurelia Bioscience.
The sector-leading expertise and technology development within Aurelia Bioscience will enable and enhance Charnwood’s provision of a world-class integrated drug discovery and development service platform as it continues to build upon its strong foundation in medicinal chemistry, scale-up and process research & development. Aurelia Bioscience is a leading preclinical CRO specialising in bioassay development, pharmacological profiling and compound screening, working in the early stages of the drug discovery pipeline including target identifica…

Monodispersed PEG linkers are pure compounds with a single molecular weight. In contrast, polydisperse PEGs linkers contain variations in molecular weight with an average molecular weight.
Monodisperse PEG products usually are organic compounds with a molecular weight of less than 1000. Monodispersed PEG linkers are pure compounds with a single molecular weight. In contrast, polydisperse PEGs linkers contain variations in molecular weight with an average molecular weight. The use of polydisperse PEGs linkers in drug development has led to problems in biological applications due to steric hindrance and binding. With advancements in both synthetic and purification chemistry over the past two decades, monodispersed PEG linkers have become more commercially viable.  Monodispersed…

Lipid nanoparticles have been developed as vehicles for small molecule delivery by the nanomedicine and materials communities and are now a key component of COVID-19 mRNA vaccines.
Vaccines against COVID-19 have been developed with unprecedented speed. In particular, mRNA vaccines — a technology already in clinical trials for other infectious diseases, such as influenza — have shown impressive efficacy in clinical trials.  mRNA vaccines rely on the delivery of mRNA into the cytoplasm of host cells, where it can be transcribed into antigenic proteins to trigger the production of neutralizing antibodies. However, mRNA is three to four orders of magnitude larger than molecules that readily diffuse into cells; in addition, the dense negative charge of mRNA electrostatically repulses the an…

There are trillions of microbes inhabiting the human intestine. These microbes gradually reach a balance of types and numbers during the process of reproduction, and this balance is closely related to the body's normal metabolism. Once the structure of the intestinal flora becomes imbalanced, various metabolic diseases will follow. The probiotics multiply in large quantities in the intestine, which can adjust the disordered intestinal flora structure and improve the body's immune ability, thereby helping to restore health.
There are trillions of microbes inhabiting the human intestine. These microbes gradually reach a balance of types and numbers during the process of reproduction, and this balance is closely related to the body's normal metabolism. Once the structure of the intestinal flor…

LABWorld China 2021, organized by Informa Markets and China Chamber of Commerce for Import and Export of Medicine and Health Products and co-organized by Sinoexpo Informa Markets, will take place during 16-18 December 2021 in SNIEC Shanghai China.
Biosecurity Law has been officially implemented since 15 April 2021. Great attention has been attached to biosecurity work and a lot has been carried out in terms of national biosecurity strategy, policy and legislation. Many related tasks have been added into the provincial government reports and listed as the main objectives of China's 14th five-year plan, including but not limited to: Strengthen the biosecurity management of pathogenic microorganism laboratory, establish national key laboratories, build provincial laboratories wi…

Lipase (Lipase, glyceride hydrolase) belongs to the class of carboxyl ester hydrolase, which can gradually hydrolyze triglycerides into glycerol and fatty acids. Lipase exists in fat-containing animal, plant and microbial (such as mold, bacteria, etc.) tissues. Including phosphatase, sterolase and carboxylesterase. Fatty acids are widely used in food, medicine, leather, daily chemicals, etc.
Lipase (Lipase, glyceride hydrolase) belongs to the class of carboxyl ester hydrolase, which can gradually hydrolyze triglycerides into glycerol and fatty acids. Lipase exists in fat-containing animal, plant and microbial (such as mold, bacteria, etc.) tissues. Including phosphatase, sterolase and carboxylesterase. Fatty acids are widely used in food, medicine, leather, daily chemicals, etc.   Lipa…

Probiotics are a class of active microorganisms used to improve the balance of the host's intestinal microflora. Its health effects were first proposed by the Russian scientist Mctchn ikoff. So far, people have found that probiotics have important physiological effects such as improving the structure of the intestinal flora, inhibiting pathogenic bacteria, eliminating carcinogenic factors, improving the body's immunity, and lowering cholesterol.
Probiotics are a class of active microorganisms used to improve the balance of the host's intestinal microflora. Its health effects were first proposed by the Russian scientist Mctchn ikoff. So far, people have found that probiotics have important physiological effects such as improving the structure of the intestinal flora, inhibiting pathogenic b…

Drug analysis refers to the detection and analysis of ingredients and contents in drugs. Drug analysis and testing are very important for drug development.
Drug analysis refers to the detection and analysis of ingredients and contents in drugs. Drug analysis and testing involves the study of composition, physical and chemical properties, purity, and the determination of the content of active pharmaceutical ingredients and their preparations, to ensure that the medications are safe, rational, and effective. Drug analysis and testing are very important for drug development, which generally encompasses disintegration test, dissolution test, tablet hardness test, tablet fragility test, residual solvents test, dosage units uniformity test, bioavailability/bioequivalence detection, microbial limi…

Excipients are very important for pharmaceutical preparations. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more convenient to use.
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more convenient to use. Divided doses are easier to be accepted by the body. However, in addition to the above-mentioned effects, excipients of the drug are also one of the important facto…

The World Health Organization’s (WHO) World Malaria Report 2020 highlighted impressive gains in malaria reduction over the past twenty years, including the prevention of an estimated 1.5 billion malaria cases and 7.6 million malaria deaths between 2000–2019. However, the founder of MedTech start-up ERADA, Dr. Benji Pretorius, says efforts to combat malaria must be accelerated if we wish to see eradication of the disease within our lifetimes.
The World Health Organization’s (WHO) World Malaria Report 2020 highlighted impressive gains in malaria reduction over the past twenty years, including the prevention of an estimated 1.5 billion malaria cases and 7.6 million malaria deaths between 2000–2019.  However, the founde…

Probiotics and gut microbiota have been international research hotspots and social hot topics in recent years. In media reports, probiotics often have various health effects and can "treat multiple diseases"; however, some media reports that "probiotics are useless" or even "probiotics are harmful." Conflicting information is not conducive to consumers' scientific cognition and reasonable choices. Therefore, this article clarifies and interprets the 6 cognitive misunderstandings of probiotics for readers' reference.
Probiotics and gut microbiota have been international research hotspots and social hot topics in recent years. In media reports, probiotics often have various health effects and can "treat multiple diseases"; however, some media reports that "probiotics are useless" or even "pro…

At the beginning of the 20th century, the enzymes in body fluids were measured clinically to diagnose diseases. For example, Wohlgemuth measured amylase (AMY) in urine as early as 1908 to diagnose acute pancreatitis. In the 1930s, alkaline phosphatase (ALP) was clinically tested for the diagnosis of skeletal diseases, and then it was found that many liver and gallbladder diseases, especially when obstructive jaundice occurred, this enzyme often increased significantly. These enzymes became routine test items in clinical laboratories at that time, and ALP was still the most frequently tested enzyme in the world until the 1960s.
At the beginning of the 20th century, the enzymes in body fluids were measured clinically to diagnose diseases. For example, Wohlgemuth measured amylase (AMY) in urin…

Choosing the proper sample size for an investigation is one of the crucial jobs required of a statistician. Regardless of whether the statistician is deciding the number of patients to select in a clinical trial, electors to finish a political survey, or mice to remember for a lab experiment, the same information elements of power, significance criteria, and effect size can be utilized too effectively.
Choosing the proper sample size for an investigation is one of the crucial jobs required of a statistician. Regardless of whether the statistician is deciding the number of patients to select in a clinical trial, electors to finish a political survey, or mice to remember for a lab experiment, the same information elements of power, significance criteria, and effect size can be utilized too e…

The importance of R programming in clinical trials is getting upturned day by day. R can be an ideal platform for measurable investigation and data perception. To biostatisticians and programmers in the pharmaceutical and biotech industry, it offers a wide and rapidly growing range of user-created packages containing capacities that can proficiently control complex data sets and create tables, figures, and postings.
These days, an immense measure of information is gathered during any clinical trial and it is basic for pharmaceutical sponsors to comprehend this information in extraordinary detail to settle on precise choices. Analysts and programmers invest a lot of energy examining data and creating reports for clinical trials, both for conclusive trial reports and break data monitoring adv…

Digestion, absorption, respiration, exercise and reproduction in life activities are all enzymatic reactions. Enzymes are the basis for cells to survive. Almost all chemical reactions involved in cell metabolism are carried out under the catalysis of enzymes.
Enzyme, early refers to "in yeast", refers to a biological catalyst produced by living cells in the organism. Most are composed of protein (a few are RNA), which can efficiently catalyze various biochemical reactions and promote the metabolism of organisms under very mild conditions in the body. Digestion, absorption, respiration, exercise and reproduction in life activities are all enzymatic reactions. Enzymes are the basis for cells to survive. Almost all chemical reactions involved in cell metabolism are carried out under the catal…

Disinfection methods are divided into physical methods, chemical methods and biological methods. The use of biological enzymes as disinfectants should be one of the biological disinfection methods. Biological disinfection is the use of animals, plants, microorganisms and (or) their metabolites to eliminate or kill pathogenic microorganisms in the environment, so as to achieve the purpose of controlling the spread of diseases.
Disinfection methods are divided into physical methods, chemical methods and biological methods. The use of biological enzymes as disinfectants should be one of the biological disinfection methods. Biological disinfection is the use of animals, plants, microorganisms and (or) their metabolites to eliminate or kill pathogenic microorganisms in the environment, so as to…

Randomization have proven to be an efficient way of reducing bias and thus is widely used in clinical trials. Randomization ensures that subject allocation is balanced across treatment group and is not influenced by external forces and thus provides equal chances for subjects to receive the treatment of interest as they are to receive the comparator treatment. But the balanced allocation across treatments may also mean exposing subjects to ineffective or less beneficial treatment.
Randomization have proven to be an efficient way of reducing bias and thus is widely used in clinical trials. Randomization ensures that subject allocation is balanced across treatment group and is not influenced by external forces and thus provides equal chances for subjects to receive the treatment of inter…

The duration and efficacy of the clinical trials for COVID-19 vaccine are the most considerable factors for the inventors. These two factors are focused based on statistical decisions. The statistical decisions are very helpful for the pharmaceuticals to get their roles quickly and more effectively. The following statistical areas played an important role in getting the COVID-19 vaccine trails quick and effective.
After all the tensions and confusion, mankind conquered COVID-19 disease through the development of effective vaccine. When you are going through the development history of vaccines, you will come across these terms; ITT Analysis, Toxicity Monitoring, Interim analysis, Immunogenicity, noninferiority, Vaccine efficacy, etc. Yes, these terms are relevant in a novel vaccine developme…

Based on the type of study designs and manuscripts, there are different types of manuscript authoring guidelines such as CONsolidated Standards Of Reporting Trials (CONSORT) for randomized trials; STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) for observational trials; CAse REport guidelines (CARE) for case reports; Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) for systematic reviews and meta-analyses; and STAndards for Reporting of Diagnostic accuracy studies (STARD) for diagnostic accurateness.
Medical Writers often seek information on global best practices that will enhance scientific manuscript writing skills while adhering to industry standards. Here we provide contemporary guidelines that should be followed while publishing…

Nanomaterials enable people to understand nature to a new level. It is a new field between atoms, molecules and macroscopic systems, which has never been explored in the past. The study of nanomaterials will bring to people a deeper understanding of the transition from micro to macro. This is a brief introduction to nanomaterials.
Nanometer (nm) is a unit of length like meters and micrometers. One nanometre can be expressed in scientific notation as 1×10−9 m, which is similar to the size of chemical bonds. Nanotechnology is a science and technology that studies the law of motion and interaction of a system composed of substances with a size between 1 and 100 nanometers, as well as possible technical problems in practical applications. Disciplines derived from these studies include: na…