Research and development - Articles
Sulfamethoxazole is mainly used in the treatment of bacterial infections such as urinary tract infections, bronchitis, and prostatitis.
Sulfamethoxazole is a crystal or white powder with the chemical name N-(5-methyl-3-isoxazolyl)-4-aminobenzenesulfonamide. It is a sulfonamide bacteriostatic antibiotic that is effective against gram negative and positive bacteria such as Listeria monocytogenes and E.coli. It is mainly used in the treatment of bacterial infections such as urinary tract infections, bronchitis, and prostatitis. Application in the treatment of bacterial infections Sulfamethoxazole was introduced to the United States in 1961. It is now mostly used in combination with trimethoprim. The combination has been included on the WHO Model List of Essential Medicine…
Sulfamethoxazole is a crystal or white powder with the chemical name N-(5-methyl-3-isoxazolyl)-4-aminobenzenesulfonamide. It is a sulfonamide bacteriostatic antibiotic that is effective against gram negative and positive bacteria such as Listeria monocytogenes and E.coli. It is mainly used in the treatment of bacterial infections such as urinary tract infections, bronchitis, and prostatitis. Application in the treatment of bacterial infections Sulfamethoxazole was introduced to the United States in 1961. It is now mostly used in combination with trimethoprim. The combination has been included on the WHO Model List of Essential Medicine…
Cardiovascular drugs are drugs used to treat diseases of the cardiovascular system, including lipid-lowering drugs, anti-heart failure drugs, anti-arrhythmic drugs, anti-hypertensive drugs, anti-anginal drugs and other chemical drugs.
Cardiovascular disease is a serious threat to human life and health. Reasonable prevention and drug treatment are the cornerstones of tackling cardiovascular disease. Cardiovascular APIs are main components of drugs used to treat diseases of the cardiovascular system, including lipid-lowering drugs, anti-heart failure drugs, anti-arrhythmic drugs, anti-hypertensive drugs, anti-anginal drugs and other chemical drugs. Antihypertensive Series There are many types of antihypertensive drugs, and different types of drugs have different curative effects o…
Cardiovascular disease is a serious threat to human life and health. Reasonable prevention and drug treatment are the cornerstones of tackling cardiovascular disease. Cardiovascular APIs are main components of drugs used to treat diseases of the cardiovascular system, including lipid-lowering drugs, anti-heart failure drugs, anti-arrhythmic drugs, anti-hypertensive drugs, anti-anginal drugs and other chemical drugs. Antihypertensive Series There are many types of antihypertensive drugs, and different types of drugs have different curative effects o…
Scotland is set to benefit from a new centre of excellence for manufacturing cutting-edge medicines after a multi-million-pound fund was announced in the Autumn Statement today (22nd November 2023).
The Centre will focus on developing innovative and sustainable manufacturing techniques in an emerging area of medicine known as oligonucleotides. Oligonucleotides can cover a wide variety of diseases, from cancer to Alzheimers, and have the potential to unlock medicines for conditions currently considered untreatable and create more effective medicines for larger patient populations such as heart disease. The Oligonucleotide Manufacturing Innovation Centre of Excellence will be the second facility opened by the Centre for Process Innovation (CPI) within the Advanced M…
The Centre will focus on developing innovative and sustainable manufacturing techniques in an emerging area of medicine known as oligonucleotides. Oligonucleotides can cover a wide variety of diseases, from cancer to Alzheimers, and have the potential to unlock medicines for conditions currently considered untreatable and create more effective medicines for larger patient populations such as heart disease. The Oligonucleotide Manufacturing Innovation Centre of Excellence will be the second facility opened by the Centre for Process Innovation (CPI) within the Advanced M…
Heart disease is a leading cause of death in the United States. The Centers for Disease Control and Prevention cite one American dies every 33 seconds because of cardiovascular disease.1 Due to the staggering numbers, heart dysfunction is a well-researched subject. Every finding brings new knowledge to the surface — and one recently led to the discovery of ferroptosis.
Heart disease is a leading cause of death in the United States. The Centers for Disease Control and Prevention cite one American dies every 33 seconds because of cardiovascular disease.1 Due to the staggering numbers, heart dysfunction is a well-researched subject. Every finding brings new knowledge to the surface — and one recently led to the discovery of ferroptosis. Ferroptosis is a form of cell death associated with many…
Heart disease is a leading cause of death in the United States. The Centers for Disease Control and Prevention cite one American dies every 33 seconds because of cardiovascular disease.1 Due to the staggering numbers, heart dysfunction is a well-researched subject. Every finding brings new knowledge to the surface — and one recently led to the discovery of ferroptosis. Ferroptosis is a form of cell death associated with many…
For the preparation of drug delivery vehicle microspheres, microfluidic technology can produce microspheres in one step without further purification, with very homogeneous particle size and good monodispersity, thus microfluidic technology shows outstanding advantages in the preparation of drug delivery vehicles.
Microfluidic technology enables the preparation of microspheres with good monodispersity and controlled particle size and morphology. Carrier microspheres can be used as drug delivery vehicles to modify the drug release efficiency and improve the accuracy of drug action at the target site. For the preparation of drug delivery vehicle microspheres, microfluidic technology can produce microspheres in one step without further purification, with very homogeneous particle size and…
Microfluidic technology enables the preparation of microspheres with good monodispersity and controlled particle size and morphology. Carrier microspheres can be used as drug delivery vehicles to modify the drug release efficiency and improve the accuracy of drug action at the target site. For the preparation of drug delivery vehicle microspheres, microfluidic technology can produce microspheres in one step without further purification, with very homogeneous particle size and…
Chromatography testing and mass spectrometry are two analytical techniques widely used in scientific research, pharmaceuticals, food safety, environmental analysis, and forensic investigations.
Chromatography testing and mass spectrometry are two analytical techniques widely used in scientific research, pharmaceuticals, food safety, environmental analysis, and forensic investigations. These techniques play a crucial role in identifying and quantifying chemical compounds, determining the purity of substances, and understanding molecular structures. In this article, we will explore the principles, applications, and benefits of chromatography testing and mass spectrometry. Chromatography Testing Chromatography is a powerful separation technique that allows scientists to separate and analyze co…
Chromatography testing and mass spectrometry are two analytical techniques widely used in scientific research, pharmaceuticals, food safety, environmental analysis, and forensic investigations. These techniques play a crucial role in identifying and quantifying chemical compounds, determining the purity of substances, and understanding molecular structures. In this article, we will explore the principles, applications, and benefits of chromatography testing and mass spectrometry. Chromatography Testing Chromatography is a powerful separation technique that allows scientists to separate and analyze co…
In drug delivery systems, marine polysaccharides can be combined with nanotechnology to improve efficacy and safety by controlling the rate, timing, and location of drug release in the body. For example, chitosan-based nanoparticles have been developed to achieve controlled release of cationic drugs, enzyme immobilization support, and encapsulation of bioactive compounds.
Source of Marine Polysaccharides Marine polysaccharides are primarily sourced from a diverse range of marine organisms that thrive in oceans and seas. Seaweeds are the primary and most abundant source of marine polysaccharides. Seaweeds with high polysaccharide content, such as red algae (Rhodophyta), brown algae (Phaeophyceae), and green algae (Chlorophyta), have been extensively studied for their polysaccharide compositi…
Source of Marine Polysaccharides Marine polysaccharides are primarily sourced from a diverse range of marine organisms that thrive in oceans and seas. Seaweeds are the primary and most abundant source of marine polysaccharides. Seaweeds with high polysaccharide content, such as red algae (Rhodophyta), brown algae (Phaeophyceae), and green algae (Chlorophyta), have been extensively studied for their polysaccharide compositi…
Conducting toxicological evaluation helps assess potential risks associated with cosmetic ingredients, ensuring consumer safety.
Cosmetics play a significant role in our daily lives, with millions of people using them to enhance their appearance or maintain their skincare routine. However, the safety of these products should always be a top priority. To ensure the safety and quality of cosmetics, thorough toxicological evaluation, and physical and chemical testing are crucial steps in the development and manufacturing process. Physical and chemical testing of cosmetics is essential to assess their quality and stability. These tests help determine the physical properties and chemical composition of the products, ensuring they meet required standards. One of the most common physical test…
Cosmetics play a significant role in our daily lives, with millions of people using them to enhance their appearance or maintain their skincare routine. However, the safety of these products should always be a top priority. To ensure the safety and quality of cosmetics, thorough toxicological evaluation, and physical and chemical testing are crucial steps in the development and manufacturing process. Physical and chemical testing of cosmetics is essential to assess their quality and stability. These tests help determine the physical properties and chemical composition of the products, ensuring they meet required standards. One of the most common physical test…
In this article, we will explore various types of microneedle patch technologies, including phase-transition microneedle patches, hydrogel microneedle patches, solid microneedles, hollow microneedles, coated microneedles, and dissolving microneedles. Each of these technologies presents unique characteristics and benefits in drug delivery applications.
Microneedle patch technologies have revolutionized the field of drug delivery, offering a wide range of advantages over traditional methods. These innovative patches provide a minimally invasive and painless alternative to injections while ensuring precise and controlled drug administration. In this article, we will explore various types of microneedle patch technologies, including phase-transition microneedle patches, hydrogel microneedl…
Microneedle patch technologies have revolutionized the field of drug delivery, offering a wide range of advantages over traditional methods. These innovative patches provide a minimally invasive and painless alternative to injections while ensuring precise and controlled drug administration. In this article, we will explore various types of microneedle patch technologies, including phase-transition microneedle patches, hydrogel microneedl…
16-Nov-2023
As with antibody detection, the most commonly used antigen detection methods are enzyme-linked immunosorbent assay (ELISA) and lateral flow immunoassay (LFIA).
Antigen Detection Raw Materials An antigen is a molecule (such as protein) that causes the immune system to produce antibodies and trigger an immune response. In the case of COVID-19, structural proteins were found on the surface of SARS-CoV-2 virus. Therefore, it is possible to determine whether a person is infected with virus by detecting the presence of these proteins of the SARS-CoV-2 virus. At present, the authorized antigen detection is mainly to detect the spike or nucleocapsid protein antigen of SARS-CoV-2 virus from nasal swabs or similar clinical specimens to quickly diagnose active infection. Antigen detection is usually l…
Antigen Detection Raw Materials An antigen is a molecule (such as protein) that causes the immune system to produce antibodies and trigger an immune response. In the case of COVID-19, structural proteins were found on the surface of SARS-CoV-2 virus. Therefore, it is possible to determine whether a person is infected with virus by detecting the presence of these proteins of the SARS-CoV-2 virus. At present, the authorized antigen detection is mainly to detect the spike or nucleocapsid protein antigen of SARS-CoV-2 virus from nasal swabs or similar clinical specimens to quickly diagnose active infection. Antigen detection is usually l…
10-Nov-2023
Broughton expands analytical testing services with a one-stop solution for Extractables and Leachables
To help pharmaceutical and consumer healthcare companies bring their products to market safely and efficiently, scientific consultancy and contract research organization (CRO) Broughton has launched a new Extractables and Leachables (E&L) testing service. Regulatory bodies increasingly focus on the interactions between manufacturing components, drug delivery devices and container-closure systems (CCS), and the final product formulation. Producers must identify and assess any toxicological risks that could arise via such interactions. Broughton’s new service will offer tailored E&L studies with a fully integrated approach that combines technical and analytical services, in-house to…
To help pharmaceutical and consumer healthcare companies bring their products to market safely and efficiently, scientific consultancy and contract research organization (CRO) Broughton has launched a new Extractables and Leachables (E&L) testing service. Regulatory bodies increasingly focus on the interactions between manufacturing components, drug delivery devices and container-closure systems (CCS), and the final product formulation. Producers must identify and assess any toxicological risks that could arise via such interactions. Broughton’s new service will offer tailored E&L studies with a fully integrated approach that combines technical and analytical services, in-house to…
Clinion has secured the top spot on the list of Clinical Trial Management Solutions for the year 2023
Austin, TX — November 08, 2023 Clinion is Named as The Top Clinical Trial Management Solution Provider of 2023 by Medhealth Review We are proud to announce that Clinion has secured the top spot on the list of Clinical Trial Management Solutions for the year 2023. This remarkable recognition underscores our commitment to transforming the landscape of clinical trials with cutting-edge AI-enabled technology. At Clinion, we’ve always aimed for excellence, and this achievement is a testament to our dedication to providing innovative solutions that streamline and enhance the entire clinical trial process. Our fully integrated eClinical software platform, equipped with EDC, IWRS/RTSM, CTMS, ePRO,…
Austin, TX — November 08, 2023 Clinion is Named as The Top Clinical Trial Management Solution Provider of 2023 by Medhealth Review We are proud to announce that Clinion has secured the top spot on the list of Clinical Trial Management Solutions for the year 2023. This remarkable recognition underscores our commitment to transforming the landscape of clinical trials with cutting-edge AI-enabled technology. At Clinion, we’ve always aimed for excellence, and this achievement is a testament to our dedication to providing innovative solutions that streamline and enhance the entire clinical trial process. Our fully integrated eClinical software platform, equipped with EDC, IWRS/RTSM, CTMS, ePRO,…
Omega-3 fatty acids are crucial in proper body functioning. Its main three forms are docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA).1 Several studies have proved the positive impact of this nutrient on heart and brain health, yet the latest one takes a new spin on auditory health.
Omega-3 fatty acids are crucial in proper body functioning. Its main three forms are docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA).1 Several studies have proved the positive impact of this nutrient on heart and brain health, yet the latest one takes a new spin on auditory health. A recent study dove into the potential benefits of one type of omega-3 fatty acid in hearing functions, citing DHA levels are inversely correlated with aud…
Omega-3 fatty acids are crucial in proper body functioning. Its main three forms are docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA).1 Several studies have proved the positive impact of this nutrient on heart and brain health, yet the latest one takes a new spin on auditory health. A recent study dove into the potential benefits of one type of omega-3 fatty acid in hearing functions, citing DHA levels are inversely correlated with aud…
02-Nov-2023
The 18th Project Portfolio and Resource Management Excellence Conference, set for February 13-15, 2024 in Northern New Jersey, is a crucial event for industry leaders. The conference focuses on optimizing resource management, aligning project strategies, navigating market pressures, and embracing innovation. With a lineup of industry experts and insightful sessions, attendees can expect to gain actionable strategies and valuable connections.
Northern New Jersey, February 13-15, 2024 In an ever-evolving pharmaceutical and biotechnology landscape, effective portfolio and project management are paramount. The 18th Project Portfolio and Resource Management Excellence Conference, set to take place in Northern New Jersey from February 13th to 15th, 2024, promises to be a crucible of insights and…
Northern New Jersey, February 13-15, 2024 In an ever-evolving pharmaceutical and biotechnology landscape, effective portfolio and project management are paramount. The 18th Project Portfolio and Resource Management Excellence Conference, set to take place in Northern New Jersey from February 13th to 15th, 2024, promises to be a crucible of insights and…
01-Nov-2023
Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide. The chemical name of it is 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphospholane-2-oxide and used for a variety of cancers.
Introduction Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide. The chemical name of it is 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphospholane-2-oxide and used for a variety of cancers. The structure is shown in fig. 1. Fig. 1 Structure of ifosfamide Application in the treatment of cancer Ifosfamide has been effectively employed in the treatment of multiple cancers, including testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, non-Hodgkin lymphoma, Ho…
Introduction Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide. The chemical name of it is 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphospholane-2-oxide and used for a variety of cancers. The structure is shown in fig. 1. Fig. 1 Structure of ifosfamide Application in the treatment of cancer Ifosfamide has been effectively employed in the treatment of multiple cancers, including testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, non-Hodgkin lymphoma, Ho…
what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper!
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…
ADMET (absorption, distribution, metabolism, excretion and toxicity) pharmacokinetic prediction method is a very important approach in drug design and drug screening.
What Is MADMET Prediction? ADMET (absorption, distribution, metabolism, excretion and toxicity) pharmacokinetic prediction method is a very important approach in drug design and drug screening. Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. Alfa Chemistry can predict ADME parameters and pharmacokinetic properties by calculating the physical and chemical…
What Is MADMET Prediction? ADMET (absorption, distribution, metabolism, excretion and toxicity) pharmacokinetic prediction method is a very important approach in drug design and drug screening. Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. Alfa Chemistry can predict ADME parameters and pharmacokinetic properties by calculating the physical and chemical…
The application of ethers in pharmaceuticals has been a topic of keen interest within the wider industry. Ethers, such as aryl and alkyl ethers, are found in various pharmaceutical compounds because of their unique physicochemical properties.
What is Ether? Ether is a product in which the hydrogen in the hydroxyl group of an alcohol or phenol is replaced by a hydrocarbon group. The general formula is R-O-R', and R and R' can represent the same or different groups. Ethers that are the same are called symmetric ethers, also known as simple ethers or monoethers; Ethers that are different from each other are called asymmetric ethers. If R and R 'are carbon atoms at both ends of an organic group, they are called cyclic ethers, such as ethylene oxide. Most ethers are colorless liquids at roo…
What is Ether? Ether is a product in which the hydrogen in the hydroxyl group of an alcohol or phenol is replaced by a hydrocarbon group. The general formula is R-O-R', and R and R' can represent the same or different groups. Ethers that are the same are called symmetric ethers, also known as simple ethers or monoethers; Ethers that are different from each other are called asymmetric ethers. If R and R 'are carbon atoms at both ends of an organic group, they are called cyclic ethers, such as ethylene oxide. Most ethers are colorless liquids at roo…
Moxifloxacin hydrochloride, with broad-spectrum bactericidal activity against gram strains, is commonly used in the treatment of respiratory tract infection, including acute sinusitis, acute attack of chronic bronchitis, community acquired pneumonia, etc.
Moxifloxacin hydrochloride is a crystalline powder which is soluble in DMSO (dimethyl sulfoxide) and dimethyl formamide. Moxifloxacin hydrochloride is an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive strains (including Corynebacterium species, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri, Streptococcus pneumoniae, and Streptococcus viridans group) and gram-negative strains (Acinetobacter l…
Moxifloxacin hydrochloride is a crystalline powder which is soluble in DMSO (dimethyl sulfoxide) and dimethyl formamide. Moxifloxacin hydrochloride is an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive strains (including Corynebacterium species, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri, Streptococcus pneumoniae, and Streptococcus viridans group) and gram-negative strains (Acinetobacter l…
26-Oct-2023
Microspheres play a crucial role in the field of pharmaceuticals, biotechnology, and materials science due to their unique properties and applications.
Microspheres play a crucial role in the field of pharmaceuticals, biotechnology, and materials science due to their unique properties and applications. These spherical particles, ranging from a few micrometers to several millimeters in size, have a wide range of uses, including drug delivery systems, cell encapsulation, and as supports for various chemical reactions. Polymeric microspheres, including poly(lactic acid-glycolic acid) copolymers (PLGA), poly(lactic acid) (PLA) and polycaprolactone (PCL) microspheres, are highly biocompatible and are widely used to develop particulate drug delivery systems. By introducing a variety of small mole…
Microspheres play a crucial role in the field of pharmaceuticals, biotechnology, and materials science due to their unique properties and applications. These spherical particles, ranging from a few micrometers to several millimeters in size, have a wide range of uses, including drug delivery systems, cell encapsulation, and as supports for various chemical reactions. Polymeric microspheres, including poly(lactic acid-glycolic acid) copolymers (PLGA), poly(lactic acid) (PLA) and polycaprolactone (PCL) microspheres, are highly biocompatible and are widely used to develop particulate drug delivery systems. By introducing a variety of small mole…
