Articles
Changes in the number of proteomes in a cell have a big effect on many aspects of life. For example, the occurrence and development of many diseases are often accompanied by abnormal expression of certain proteins. Quantitative proteomics is the accurate quantification and identification of all proteins expressed in a genome or all proteins in a complex mixed system. At present, quantitative proteomics technology is mainly divided into labeling strategies and non-labeling strategies, in which the labeling strategies are divided into in vivo labeling (such as SILAC), and in vitro labeling (such as iTRAQ, TMT).
Changes in the number of proteomes in a cell have a big effect on many aspects of life. For example, the occurrence and development of many diseases are often accompanied by abnormal e…
Changes in the number of proteomes in a cell have a big effect on many aspects of life. For example, the occurrence and development of many diseases are often accompanied by abnormal e…
Polysaccharides are made by polymerizing more than 10 monosaccharide molecules through glycosidic bonds. The molecular weight of polysaccharides is relatively large, usually consisting of hundreds or even tens of thousands of monosaccharide molecules.
Polysaccharides are made by polymerizing more than 10 monosaccharide molecules through glycosidic bonds. The molecular weight of polysaccharides is relatively large, usually consisting of hundreds or even tens of thousands of monosaccharide molecules. Polysaccharides, together with nucleic acids, proteins, and lipids, are called the four basic substances of life and play important roles in many life activities. The biological activities of polysaccharides are continuing to be discovered. Some known activities include immune regulation, anti-tu…
Polysaccharides are made by polymerizing more than 10 monosaccharide molecules through glycosidic bonds. The molecular weight of polysaccharides is relatively large, usually consisting of hundreds or even tens of thousands of monosaccharide molecules. Polysaccharides, together with nucleic acids, proteins, and lipids, are called the four basic substances of life and play important roles in many life activities. The biological activities of polysaccharides are continuing to be discovered. Some known activities include immune regulation, anti-tu…
Post-translational modification of proteins is a covalent process that a protein goes through during or after translation. This process changes the properties of a protein by adding one or more amino acid residues to a modification group or by proteolytically cutting the group, which is an important step in the expression of protein biological functions. Post-translational modifications of biological proteins greatly increase the types and functions of protein structures. This process regulates the cell cycle and protein transcription and affects epigenetics.
What is Post-Translational Modification of Proteins? Post-translational modification of proteins is a covalent process that a protein goes through during or after translation. This process changes the properties of a protein by ad…
What is Post-Translational Modification of Proteins? Post-translational modification of proteins is a covalent process that a protein goes through during or after translation. This process changes the properties of a protein by ad…
The proteome is the sequence identification and content analysis of all proteins in a living organism, but the information of PTM (post-translational modification) cannot be ignored. Phosphorylation proteins account for about 1/3 of all proteins in organisms, so phosphorylation has become one of the types of protein PTMs that has received the most attention.
The proteome is the sequence identification and content analysis of all proteins in a living organism, but the information of PTM (post-translational modification) cannot be ignored. Phosphorylation proteins account for about 1/3 of all proteins in organisms, so phosphorylation has become one of the types of protein PTMs that has received the most attention. Common phosphorylated protein identification methods Western-blot The pr…
The proteome is the sequence identification and content analysis of all proteins in a living organism, but the information of PTM (post-translational modification) cannot be ignored. Phosphorylation proteins account for about 1/3 of all proteins in organisms, so phosphorylation has become one of the types of protein PTMs that has received the most attention. Common phosphorylated protein identification methods Western-blot The pr…
31-Mar-2023
Employee appreciation is essential for creating a positive work environment, building strong teams, and ultimately retaining top talent. Showing gratitude for your employees' hard work and dedication can go a long way in boosting morale, motivation, and engagement. In this article, we've outlined 10 ways you can show appreciation for your employees, from saying thank you to celebrating a range of cultural and religious holidays.
Employee appreciation is essential for creating a positive work environment, building strong teams, and ultimately retaining top talent. Showing gratitude for your employees' hard work and dedication can go a long way in boosting morale, motivation, and engagement. In this article, we've outlined 10 ways you can show appreciation for your employees, from saying than…
Employee appreciation is essential for creating a positive work environment, building strong teams, and ultimately retaining top talent. Showing gratitude for your employees' hard work and dedication can go a long way in boosting morale, motivation, and engagement. In this article, we've outlined 10 ways you can show appreciation for your employees, from saying than…
02-Mar-2023
The following is a brief summary of changes within the Northern Ireland regulatory landscape following the issuance of the Windsor Framework on 27th Feb 2023.
The following is a brief summary of changes within the Northern Ireland regulatory landscape following the issuance of the Windsor Framework on 27th Feb 2023. The agreement, in principle, has been reached by the UK and EU regarding the Windsor Framework. The new way forward on the Windsor Framework marks a turning point in how both the UK and the EU will work together collaboratively and constructively. Whilst this is a successful result for Northern Ireland patients, this is major change for companies that have made specific provisions in their supply chains for Northern Ireland. This may impact the supply chains of companies where p…
The following is a brief summary of changes within the Northern Ireland regulatory landscape following the issuance of the Windsor Framework on 27th Feb 2023. The agreement, in principle, has been reached by the UK and EU regarding the Windsor Framework. The new way forward on the Windsor Framework marks a turning point in how both the UK and the EU will work together collaboratively and constructively. Whilst this is a successful result for Northern Ireland patients, this is major change for companies that have made specific provisions in their supply chains for Northern Ireland. This may impact the supply chains of companies where p…
Whole genome sequencing looks at the whole genome of an organism, while targeted region sequencing looks at only the parts that are of interest. Targeted genome sequencing is a very sensitive and specific way to find SNPs, indels, CNVs, and large SVs.
What is targeted region sequencing? Whole genome sequencing looks at the whole genome of an organism, while targeted region sequencing looks at only the parts that are of interest. Targeted genome sequencing is a very sensitive and specific way to find SNPs, indels, CNVs, and large SVs. Compared to whole genome sequencing, targeted genome sequencing is more focused, economical, and effective. Furthermore, targeted regions can be sequenced at a much greater depth for a lower cost, which contributes to detecting rare variations. Whole exome seq…
What is targeted region sequencing? Whole genome sequencing looks at the whole genome of an organism, while targeted region sequencing looks at only the parts that are of interest. Targeted genome sequencing is a very sensitive and specific way to find SNPs, indels, CNVs, and large SVs. Compared to whole genome sequencing, targeted genome sequencing is more focused, economical, and effective. Furthermore, targeted regions can be sequenced at a much greater depth for a lower cost, which contributes to detecting rare variations. Whole exome seq…
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases.
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases. The human genome contains approximately 3 billion base pairs of DNA. Among them, only about 30 million base pairs of DNA carry the information for protein synthesis. This part of the genome is…
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases. The human genome contains approximately 3 billion base pairs of DNA. Among them, only about 30 million base pairs of DNA carry the information for protein synthesis. This part of the genome is…
Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics research. At the moment, Illumina, Ion Torrent/Life Technologies, 454/Roche, Pacific Bioscience, Nanopore, and GenapSys are all NGS platforms that can be used. They can produce reads of 100–10,000 bp in length, enabling sufficient coverage of the genome at a lower cost. But faced with the enormous amount of sequence data, how do we best deal with it? And what are the most appropriate computational methods and analysis tools for this purpose? In this review, we focus on the bioinformatics pipeline of whole exome sequencing (WES).
Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics resear…
Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics resear…
In competition with bacteriophages, bacteria and archaea have evolved unique ways of defending, which include the CRISPR/Cas systems and the immune systems of bacteria and archaea, which resist the invasion of foreign DNA or RNA and recognize the foreign invaders and cleave them for immune defense.
In competition with bacteriophages, bacteria and archaea have evolved unique ways of defending, which include the CRISPR/Cas systems and the immune systems of bacteria and archaea, which resist the invasion of foreign DNA or RNA and recognize the foreign invaders and cleave them for immune defense. CRISPR/Cas systems are now useful research tools that are easy to use and work well in the field of genetic engineering. In a CRISPR/Cas9-induced gene editing process, for example, the Cas9 enzy…
In competition with bacteriophages, bacteria and archaea have evolved unique ways of defending, which include the CRISPR/Cas systems and the immune systems of bacteria and archaea, which resist the invasion of foreign DNA or RNA and recognize the foreign invaders and cleave them for immune defense. CRISPR/Cas systems are now useful research tools that are easy to use and work well in the field of genetic engineering. In a CRISPR/Cas9-induced gene editing process, for example, the Cas9 enzy…
In this article, we explore 9 practical ways of winning and retaining top clients, from building a strong online presence to providing an innovative and evolving portfolio of services. Whether you are just starting out as a pharmaceutical recruitment agency or are looking to improve your current client retention rates, these tips will help you to stand out from your competition and build long-lasting relationships with your prospective and current clients.
As a Pharmaceutical recruitment agency, competition for top clients is tough, particularly in a time when business costs are rising, and many pharmaceutical companies are cutting back on their outsourcing as well as their hiring. In this article, we explore 9 practical ways of winning and retaining top clients, from building a strong onli…
As a Pharmaceutical recruitment agency, competition for top clients is tough, particularly in a time when business costs are rising, and many pharmaceutical companies are cutting back on their outsourcing as well as their hiring. In this article, we explore 9 practical ways of winning and retaining top clients, from building a strong onli…
01-Mar-2023
There is an ongoing trend in the pharmaceutical industry to outsource activities to external vendors. When such outsourcing affects GMDP-activities, and is therefore related to EU Good Manufacturing Practice (GMP) or Good Distribution Practice (GDP), defined regulatory requirements must be respected in the process of outsourcing.
There is an ongoing trend in the pharmaceutical industry to outsource activities to external vendors. When such outsourcing affects GMDP-activities, and is therefore related to EU Good Manufacturing Practice (GMP) or Good Distribution Practice (GDP), defined regulatory requirements must be respected in the process of outsourcing. One of the main misunderstandings that I observe in my role as an auditor and GxP-consultant is that outsourcing of activities does not m…
There is an ongoing trend in the pharmaceutical industry to outsource activities to external vendors. When such outsourcing affects GMDP-activities, and is therefore related to EU Good Manufacturing Practice (GMP) or Good Distribution Practice (GDP), defined regulatory requirements must be respected in the process of outsourcing. One of the main misunderstandings that I observe in my role as an auditor and GxP-consultant is that outsourcing of activities does not m…
A 2022 report by the Lancet Neurology Commission reveals traumatic brain injury is a global public health concern that affects 55 million people worldwide, according to Neuroscience News. Traumatic brain injuries (TBI) are severe incidents that often lead to disabilities and injury-related deaths.
A 2022 report by the Lancet Neurology Commission reveals traumatic brain injury is a global public health concern that affects 55 million people worldwide, according to Neuroscience News. Traumatic brain injuries (TBI) are severe incidents that often lead to disabilities and injury-related deaths. With increasing road accidents, sports injuries, and demand for non-invasive brain injury assessment and treatment procedures, the global traumatic brain injuries treatment market will reach over $2650 b…
A 2022 report by the Lancet Neurology Commission reveals traumatic brain injury is a global public health concern that affects 55 million people worldwide, according to Neuroscience News. Traumatic brain injuries (TBI) are severe incidents that often lead to disabilities and injury-related deaths. With increasing road accidents, sports injuries, and demand for non-invasive brain injury assessment and treatment procedures, the global traumatic brain injuries treatment market will reach over $2650 b…
A recent article in the Nursing Times revealed that only 21% of nurses and midwives in the UK were content with the number of employees present at their organisations. This information was plucked from the latest NHS Staff Survey, and appears only to represent the tip of the iceberg regarding healthcare professionals and their workplace satisfaction.
A recent article in the Nursing Times revealed that only 21% of nurses and midwives in the UK were content with the number of employees present at their organisations. This information was plucked from the latest NHS Staff Survey, and appears only to represent the tip of the iceberg regarding healthcare professionals and their workplace satisfaction. While this highlights a major need for change in this industry, there is thankfully a light at…
A recent article in the Nursing Times revealed that only 21% of nurses and midwives in the UK were content with the number of employees present at their organisations. This information was plucked from the latest NHS Staff Survey, and appears only to represent the tip of the iceberg regarding healthcare professionals and their workplace satisfaction. While this highlights a major need for change in this industry, there is thankfully a light at…
Bachem, a Swiss pharmaceutical company, has partnered with the SimplyNano project, educational experiment kits published by the non-profit foundation SimplyScience. This project aims to get young people excited about science and technology with the help of nano experiments.
The project involves the “SimplyNano 2”, which is a comprehensive nano-experimental kit for schools. Published by the SimplyScience Foundation and developed by Innovationsgesellschaft (a St. Gallen-based start-up), these kits are available free of charge for some secondary schools in northwestern Switzerland. By 2025, the SimplyNano 2 experiment kits should be available throughout Switzerland.
Bachem, a Swiss pharmaceutical company, has partnered with the SimplyNano project, educational experiment kits published by t…
Bachem, a Swiss pharmaceutical company, has partnered with the SimplyNano project, educational experiment kits published by t…
Decentralization allows for more diverse patient participation and improved data collection, leading to faster, more accurate results in clinical trials.
With the emergence of COVID-19, the Decentralization of Clinical Trials became necessary to comply with social distancing requirements while carrying out clinical research. Over the past few years, the clinical trial landscape has shifted its focus to patient-centric practices to promote patient engagement. But now as the pandemic is long gone, it is time to reflect on how DCT studies are genuinely addressing long-standing issues in research and development for sponsors, study teams, and of course, the patients! The digital shift in clinical trials has brought about the potential to improve both patient experience and clinical data qualit…
With the emergence of COVID-19, the Decentralization of Clinical Trials became necessary to comply with social distancing requirements while carrying out clinical research. Over the past few years, the clinical trial landscape has shifted its focus to patient-centric practices to promote patient engagement. But now as the pandemic is long gone, it is time to reflect on how DCT studies are genuinely addressing long-standing issues in research and development for sponsors, study teams, and of course, the patients! The digital shift in clinical trials has brought about the potential to improve both patient experience and clinical data qualit…
the pharmaceutical industry is undergoing significant changes, with emerging trends that will shape its future. Companies that stay up-to-date with these trends and invest in the right technologies and strategies will be better positioned to succeed in this dynamic and challenging industry. From personalized medicine and digital therapeutics to data analytics and AI, there are plenty of opportunities for innovation and growth in the years to come.
The pharmaceutical industry has undergone a lot of changes in recent years. With advancements in technology, changing consumer behavior, and increasing regulatory scrutiny, companies in this sector must stay up-to-date with the latest trends in order to remain competitive. In this article, we will explore the top emerging trends that are expected…
The pharmaceutical industry has undergone a lot of changes in recent years. With advancements in technology, changing consumer behavior, and increasing regulatory scrutiny, companies in this sector must stay up-to-date with the latest trends in order to remain competitive. In this article, we will explore the top emerging trends that are expected…
As the Life Sciences industry embraces a future that is data rather than document driven, companies have some practical questions to answer, such as who will make this happen? Thought leaders from BioNTech, Bayer, Iperion - a Deloitte business, and Beczek.COM recently came together for a Big Debate on the topic over video link. Generis COO Max Kelleher chaired the proceedings.
On the panel were: Dr. Melanie Ruppel, Senior Director Global Regulatory Affairs Regulatory Operations, BioNTech Vada A. Perkins, Executive Director, Regulatory Policy & Intelligence and Head of Regulatory Intelligence, Bayer Pharmaceuticals Frits Stulp, Managing Director, Iperion - a Deloitte business Preeya Beczek, Director & Independent Regulatory Affairs Expert, Beczek.COM Frits Stulp of Iperion – a Delo…
On the panel were: Dr. Melanie Ruppel, Senior Director Global Regulatory Affairs Regulatory Operations, BioNTech Vada A. Perkins, Executive Director, Regulatory Policy & Intelligence and Head of Regulatory Intelligence, Bayer Pharmaceuticals Frits Stulp, Managing Director, Iperion - a Deloitte business Preeya Beczek, Director & Independent Regulatory Affairs Expert, Beczek.COM Frits Stulp of Iperion – a Delo…
The global clinical trials market was estimated to be worth $38.7 billion in 2021 and is expected to reach £52 billion by 2026. In this article, we look at the top 12 CROs in the world, highlighting the companies driving this considerable growth and accelerating research and development across the globe.
The global clinical trials market was estimated to be worth $38.7 billion in 2021 and is expected to reach £52 billion by 2026. In this article, we look at the top 12 CROs in the world, highlighting the companies driving this considerable growth and accelerating research and development across the globe. ICON Recognised as the world’s largest and most comprehensive CRO powered by Healthcare Intelligence, ICON provides outsourced development and commercialisation services to pharmaceutical,…
The global clinical trials market was estimated to be worth $38.7 billion in 2021 and is expected to reach £52 billion by 2026. In this article, we look at the top 12 CROs in the world, highlighting the companies driving this considerable growth and accelerating research and development across the globe. ICON Recognised as the world’s largest and most comprehensive CRO powered by Healthcare Intelligence, ICON provides outsourced development and commercialisation services to pharmaceutical,…
Cell and gene therapy clinical research is a rapidly growing field that holds great promise for the treatment of a wide range of diseases. These therapies involve the use of living cells or genes to treat or prevent diseases and have the potential to revolutionize the way we approach healthcare.
Changing Cell & Gene Therapy Landscape and Implications on Clinical Trials By Elizabeth Dugan, Director, Business Development on December, 20 2022 Cell & Gene Therapy Background Cell and gene therapy clinical research is a rapidly growing field that holds great promise for the treatment of a wide range of diseases. These therapies involve the use of living cells or genes to treat or prevent diseases and have the potential to revolutionize the way we approach healthcare. One key as…
Changing Cell & Gene Therapy Landscape and Implications on Clinical Trials By Elizabeth Dugan, Director, Business Development on December, 20 2022 Cell & Gene Therapy Background Cell and gene therapy clinical research is a rapidly growing field that holds great promise for the treatment of a wide range of diseases. These therapies involve the use of living cells or genes to treat or prevent diseases and have the potential to revolutionize the way we approach healthcare. One key as…
