Articles

From over-the-counter flu tablets to crucial antibiotics and antidepressants, medicines are running scarce in UK pharmacies this year, causing concerns among patients, the government, and the wider pharma industry. Drug shortages have accelerated over the past year due to a clutch of problems including the after-effects of the pandemic on supply chains, the war in Ukraine, and soaring input costs weighing on manufacturers.
From over-the-counter flu tablets to crucial antibiotics and antidepressants, medicines are running scarce in UK pharmacies this year, causing concerns among patients, the government, and the wider pharma industry.Drug shortages have accelerated over the past year due to a clutch of problems including the after-effects of the pandemic on supply chains, the war in Ukraine,…

The Life Sciences market is in a state of flux, with disruption to international supply chains and consolidation on the rise. This has created a dynamic and unpredictable global marketplace that has made it difficult for drug companies to ensure end-to-end quality and safety. In this article, Helen Lowe from Arriello examines how drug companies can navigate this complex landscape and maintain confidence in their end-to-end safety profile.
Throughout the drug authorisation process and right across the marketing authorisation lifecycle, licence holders are responsible for ensuring the continuous monitoring of the safety profile of a medicinal product. This includes accountability for all third parties and contractors with a potential impact on that safety profile. Relevant suppliers could inc…

Dermacosmetics are skincare products that are formulated with active ingredients specifically chosen for their beneficial effects on the skin. These ingredients are backed by scientific research and have been shown to improve the appearance and health of the skin. Dermacosmetics are developed with the help of dermatologists and other skincare experts, and often contain higher concentrations of active ingredients than regular cosmetics. They are formulated to be gentle and non-irritating to the skin, and are often free of harsh chemicals and fragrances. Popular dermacosmetic ingredients include retinoids, vitamin C, hyaluronic acid, AHAs, and salicylic acid. Overall, dermacosmetics offer a science-backed approach to skincare that can help to address a wide range of skin concerns.
Dermaco…

Scientists have developed a new way of using cancers’ DNA to spot cancer patients who may benefit from immunotherapy. Researchers developed a computer algorithm to tell the difference between two different strategies that tumours use to hide from the immune system - one of which is better at dodging the effects of immunotherapy than the other.
Using cancers’ DNA could guide treatment by assessing likelihood of responding to immunotherapy The pattern of DNA alterations shows the strategies of cancer cells for evading the immune system Method provides new way to measure how and when the immune system attacks cancers Scientists have developed a new way of using cancers’ DNA to spot cancer patients who may benefit from immunotherapy. Researchers developed a computer algorithm to tell the dif…

A Clinical Trial Manager (CTM) is responsible for managing the planning, implementation, and monitoring of clinical trials. The primary role of a CTM is to ensure that clinical trials are conducted according to protocol, on time, within budget, and in compliance with regulatory requirements.
A Clinical Trial Manager (CTM) is responsible for managing the planning, implementation, and monitoring of clinical trials. The primary role of a CTM is to ensure that clinical trials are conducted according to protocol, on time, within budget, and in compliance with regulatory requirements. What are the Main Responsibilities of a CTM? Whilst the role of a CTM will vary from job to job, some of the key responsibilities often include: Developing the clinical trial protocol in collaboration with the stud…

Decentralization allows for more diverse patient participation and improved data collection, leading to faster, more accurate results in clinical trials.
With the emergence of COVID-19, the Decentralization of Clinical Trials became necessary to comply with social distancing requirements while carrying out clinical research. Over the past few years, the clinical trial landscape has shifted its focus to patient-centric practices to promote patient engagement. But now as the pandemic is long gone, it is time to reflect on how DCT studies are genuinely addressing long-standing issues in research and development for sponsors, study teams, and of course, the patients! The digital shift in clinical trials has brought about the potential to improve both patient experience and clinical data qualit…

During the coronavirus pandemic, telemedicine became a popular solution enabling patients to access their healthcare facilities without virus exposure. However, even when the pandemic has subsided, some patients still need telemedicine as an easily accessible healthcare option.
These are the underserved patients, including the rural population, chronic condition patients, and older adults. They often delay their medical visits because of the transportation barrier, poor health, or inability to incur medical costs. So can telemedicine software development help provide a viable alternative to in-person medical visits for such patients? We’ll look into the matter. Rural dwellers Transportation difficulties often complicate access to care in remote and rural areas. In such locations, medical fa…

The world of healthcare is changing, with new frameworks, regulations and challenges. Having suitable systems put in place to help healthcare professionals prioritise the safety of patients and staff members is of the utmost importance. Below, the experts on behalf of healthcare quality & compliance software providers Radar Healthcare highlight how recently passed legislation will help to provide more openness and transparency within healthcare services.
The world of healthcare is changing, with new frameworks, regulations and challenges. Having suitable systems put in place to help healthcare professionals prioritise the safety of patients and staff members is of the utmost importance.  Below, the experts on behalf of healthcare quality & compliance software providers Radar Healthcare…

High performance liquid chromatography is an important branch of chromatography. It uses liquid as the mobile phase, and uses a high-pressure injection system to pump single solvents with different polarities or solvents and buffers with different mixing ratios into the column containing the stationary phase.
What is HPLC technology? High performance liquid chromatography (HPLC) is also called "high-speed liquid chromatography", "high-resolution liquid chromatography", "modern column chromatography" and so on. High performance liquid chromatography is an important branch of chromatography. It uses liquid as the mobile phase, and uses a high-pressure injection system to pump single solvents with different polarities or solvents and buffers with different mixing ratios into the column c…

Polyethylene glycol (PEG), a compound composed of repeated ethylene glycol units [-(CH2CH2O)n], is also known as Macrogols. PEG and PEG derivatives have the characteristics of non-irritation, good water solubility, good compatibility, etc. . At the same time, they possess excellent lubricity, moisture retention and dispersibility so that they can be used as adhesives, antistatic agents and softeners, and widely applied in cosmetics, pharmaceuticals, chemical fibers, rubber, plastics, paper, paint, electroplating, pesticides, metal processing and food processing industries.
Synthesis of PEG PEG can be synthesized via anionic polymerization of ethylene oxide and any hydroxyl initiators. Hydroxyl group could be from water or ethylene glycol or any diols. They can also be derived from epoxyetha…

Growing up in Romania, influenced by her family, Dr Carmen Guguta, global head of business development at Technobis Crystallization Systems, had an interest in science from a very young age. At five years old, Guguta was already fascinated by chemical reactions, and specifically remembers one of her cousins conducting a colour change experiment for her. On International Women’s Day, Guguta shares her story of growing up as a female in the lab.
The future of science is female ~ Inspiring more females into science for International Women’s Day ~   Growing up in Romania, influenced by her family, Dr Carmen Guguta, global head of business development at Technobis Crystallization Systems, had an interest in science from a very young age. At five years old, Guguta was already fascinated by c…

Probiotics are living microorganisms that offer numerous health benefits when consumed in adequate amounts. These beneficial bacteria can be found in various fermented foods such as yogurt, kefir, sauerkraut, and kimchi, as well as in dietary supplements. The term "probiotic" is derived from the Greek words "pro" and "biotic," which mean "for life." Probiotics have gained popularity in recent years, as more people have become aware of the crucial role of the gut microbiome in maintaining overall health.
Probiotics are living microorganisms that offer numerous health benefits when consumed in adequate amounts. These beneficial bacteria can be found in various fermented foods such as yogurt, kefir, sauerkraut, and kimchi, as well as in dietary supplements. The term "probiotic" is derived fro…

Enzymes are biomolecules that catalyze chemical reactions in living organisms. In agriculture, enzymes play a crucial role in various aspects, such as crop production, soil fertility, and pest management. Agriculture enzymes refer to the enzymes that are used in farming practices to improve crop yield and quality. In this article, we will discuss the classification of agriculture enzymes and their applications in agriculture.
Enzymes are biomolecules that catalyze chemical reactions in living organisms. In agriculture, enzymes play a crucial role in various aspects, such as crop production, soil fertility, and pest management. Agriculture enzymes refer to the enzymes that are used in farming practices to improve crop yield and quality. In this article, we will discuss the classification of…

Capacity, cost, and performance. Three of your top data storage priorities? No wonder, and it’s the same for most organisations across the healthcare sector. The volume of data healthcare organisations produce is in overdrive. That, added to legal requirements to store that data for very long periods of time, impacts the size of your data centre, how far your budget will stretch, and how quickly data can be moved. This growth is a major challenge for many data storage vendors today: requirements for storage capacity and longevity continue to expand with no signs of slowing down in sight. Enter DNA storage. A technology promising to store millions upon millions of gigabytes in just a few particles, for thousands of years.
Capacity, cost, and performance. Three of your top data storage pri…

Changes in the number of proteomes in a cell have a big effect on many aspects of life. For example, the occurrence and development of many diseases are often accompanied by abnormal expression of certain proteins. Quantitative proteomics is the accurate quantification and identification of all proteins expressed in a genome or all proteins in a complex mixed system. At present, quantitative proteomics technology is mainly divided into labeling strategies and non-labeling strategies, in which the labeling strategies are divided into in vivo labeling (such as SILAC), and in vitro labeling (such as iTRAQ, TMT).
Changes in the number of proteomes in a cell have a big effect on many aspects of life. For example, the occurrence and development of many diseases are often accompanied by abnormal e…

Polysaccharides are made by polymerizing more than 10 monosaccharide molecules through glycosidic bonds. The molecular weight of polysaccharides is relatively large, usually consisting of hundreds or even tens of thousands of monosaccharide molecules.
Polysaccharides are made by polymerizing more than 10 monosaccharide molecules through glycosidic bonds. The molecular weight of polysaccharides is relatively large, usually consisting of hundreds or even tens of thousands of monosaccharide molecules. Polysaccharides, together with nucleic acids, proteins, and lipids, are called the four basic substances of life and play important roles in many life activities. The biological activities of polysaccharides are continuing to be discovered. Some known activities include immune regulation, anti-tu…

Post-translational modification of proteins is a covalent process that a protein goes through during or after translation. This process changes the properties of a protein by adding one or more amino acid residues to a modification group or by proteolytically cutting the group, which is an important step in the expression of protein biological functions. Post-translational modifications of biological proteins greatly increase the types and functions of protein structures. This process regulates the cell cycle and protein transcription and affects epigenetics.
What is Post-Translational Modification of Proteins? Post-translational modification of proteins is a covalent process that a protein goes through during or after translation. This process changes the properties of a protein by ad…

The proteome is the sequence identification and content analysis of all proteins in a living organism, but the information of PTM (post-translational modification) cannot be ignored. Phosphorylation proteins account for about 1/3 of all proteins in organisms, so phosphorylation has become one of the types of protein PTMs that has received the most attention.
The proteome is the sequence identification and content analysis of all proteins in a living organism, but the information of PTM (post-translational modification) cannot be ignored. Phosphorylation proteins account for about 1/3 of all proteins in organisms, so phosphorylation has become one of the types of protein PTMs that has received the most attention.   Common phosphorylated protein identification methods Western-blot The pr…

Employee appreciation is essential for creating a positive work environment, building strong teams, and ultimately retaining top talent. Showing gratitude for your employees' hard work and dedication can go a long way in boosting morale, motivation, and engagement. In this article, we've outlined 10 ways you can show appreciation for your employees, from saying thank you to celebrating a range of cultural and religious holidays.
Employee appreciation is essential for creating a positive work environment, building strong teams, and ultimately retaining top talent. Showing gratitude for your employees' hard work and dedication can go a long way in boosting morale, motivation, and engagement. In this article, we've outlined 10 ways you can show appreciation for your employees, from saying than…

The following is a brief summary of changes within the Northern Ireland regulatory landscape following the issuance of the Windsor Framework on 27th Feb 2023.
The following is a brief summary of changes within the Northern Ireland regulatory landscape following the issuance of the Windsor Framework on 27th Feb 2023. The agreement, in principle, has been reached by the UK and EU regarding the Windsor Framework. The new way forward on the Windsor Framework marks a turning point in how both the UK and the EU will work together collaboratively and constructively. Whilst this is a successful result for Northern Ireland patients, this is major change for companies that have made specific provisions in their supply chains for Northern Ireland. This may impact the supply chains of companies where p…