Articles

The functions of MSCs mainly include differentiation capacity, immune regulation and antimicrobial properties. Differentiation capacity indicates the identity of MSCs stem cells and makes it become the basis for maintaining organ and tissue survival [16]. MSCs are also involved in immunomodulatory processes. MSCs can affect a variety of innate and specific immune cells and can produce a variety of immune factors. And the antibacterial ability of MSCs mainly comes from their ability to produce a variety of antibacterial peptides, which enables MSCs to have broad-spectrum antibacterial activity.
Introduction What are Stem Cells? Stem cells refer to undifferentiated or partially differentiated cells in multicellular organisms. Stem cells can replicate indefinitely and differentiate into differ…

It’s been a busy few years at PharmiWeb as we continue our growth on a global scale. After establishing ourselves as a leading Life Science job board, we have been focused on developing our entire range of Talent Acquisition solutions, introducing new features and resources to help our clients continue to locate and engage the best talent in the industry.
It’s been a busy few years at PharmiWeb as we continue our growth on a global scale. After establishing ourselves as a leading Life Science job board, we have been focused on developing our entire range of Talent Acquisition solutions, introducing new features and resources to help our clients continue to locate and engage the best talent in the industry. Here, we’ve rounded up some of our key milestones over the past few years, sharing in…

Whenever a foreign substance is introduced into the body, there will be a chance of rejection or having an adverse reaction. This reaction is the risk taken when trusting the pharmaceuticals that we have come to rely on for our wellness. We need these drugs, but sometimes other circumstances tell us otherwise.
Whenever a foreign substance is introduced into the body, there will be a chance of rejection or having an adverse reaction. This reaction is the risk taken when trusting the pharmaceuticals that we have come to rely on for our wellness. We need these drugs, but sometimes other circumstances tell us otherwise. What is an Adverse Drug Reaction? An Adverse Drug Reaction is also known as an ADR - the unwanted or uncomfortable effects of a drug. ADRs can also be dangerous to the one exper…

15 Pharma and Life Science events taking place in June 2022, including Pharmaceutical, Biotechnology, Clinical Research and Medical Devices events.
15 Pharma and Life Science events taking place in June 2022, including Pharmaceutical, Biotechnology, Clinical Research and Medical Devices events. 13th Edition Biologics Formulation Development and Drug Delivery Conference (June 1st-3rd) This industry-wide known marcus evans conference will gather experienced pharma industry scientists and academics to discuss key challenges around biologics drug development. International Congress of Micro-Immunotherapy (ICoMI) (June 2nd-4th) This virtual conference is open to researchers, healthcare and medical professionals looking for up-to-date knowledge and medical experience, new impulses for research an…

Having weathered a global pandemic and the war in Ukraine, the medical technology industry might be forgiven for believing – or at least hoping – that the worst may soon be over. A cost-of-living crisis should not, on the face of it, be something that would directly affect companies involved in the production of surgical equipment and medical technology, but risk lurks in the unlikeliest of corners.
Having weathered a global pandemic and the war in Ukraine, the medical technology industry might be forgiven for believing – or at least hoping – that the worst may soon be over. A cost-of-living crisis should not, on the face of it, be something that would directly affect companies involved in the production of surgical equipment and medical technology, but risk lurks in the unlikeliest of corn…

Burnout can cause people to make mistakes such as duplications, incorrect information, and late data entry causing incorrect decision-making. Being one of the most passionate and necessary industries, it is important that healthcare workers including nurses, doctors and clinicians are given the right amount of support. With this in mind, Hannah Wilkinson, Head of People & Culture at Radar Healthcare, shares five ways health tech companies can alleviate burnout across the workforce.
Around 400 staff are leaving the NHS every week due to the effects of stress, including burnout and PTSD, in the workplace.  Burnout can cause people to make mistakes such as duplications, incorrect information, and late data entry causing incorrect decision-making.  Being one of the most passionate and necessary…

Industries are continuously evolving, and the pharma industry is no exception. There are trends impacting the way we think about pharma, how pharma development is conducted, and the opportunities for pharma to make an impact on a societal level. Looking ahead, we can see a few trends that have emerged and that are gaining traction within the industry. This in turn influences how portfolio management is perceived and what it is expected to deliver.
Industries are continuously evolving, and the pharma industry is no exception. There are trends impacting the way we think about pharma, how pharma development is conducted, and the opportunities for pharma to make an impact on a societal level. Looking ahead, we can see a few trends that have emerged and that are gaining traction within the indus…

Understanding what decisions to make about the future is no easy task. In an earlier article, we outlined the 6 best practices in pharma decision-making, activities crucial to making the decision process efficient, less time-consuming, and more accurate. As the current situation is, the processes commonly used to manage data for forecasting purposes offer significant opportunities for improvement.
Understanding what decisions to make about the future is no easy task. In an earlier article, we outlined the 6 best practices in pharma decision-making, activities crucial to making the decision process efficient, less time-consuming, and more accurate. As the current situation is, the processes commonly used to manage data for forecasting purposes offer significant opportunities for improvement.…

In the workplace, burnout can have a huge impact on employee engagement, leading to low productivity and high staff turnover. On the flip side, effectively preventing burnout can improve employee retention and help to attract future talent. This article outlines 13 ways Life Science employers can reduce employee burnout; from writing a descriptive and well-thought-out job description to redesigning the physical workplace.
With the Life Science industry being put under more pressure than ever in recent years, employee burnout is on the rise. The World Health Organization (WHO) define burnout as “a syndrome conceptualised as resulting from chronic workplace stress that has not been successfully managed.” According to WHO, symptoms include: Energy depletion and exhaustion Mental distance from…

The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions.
Benefits of forced degradation test The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions. Provide support for drug safety. When toxicologically relevant impurities are not readily available, toxicological evaluation of samples degraded to a certain extent can provide a supportive basis for drug safety and impurity limit determination. It is helpful for metabolite research. Some degradation products are also metabolites, and the m…

Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those non-coding fragments in human genes are also vital and not the so-called "transcriptional noise".
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferatio…

Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present the application of bioinformatics in the study and fight against cancer and infectious diseases.
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ…

With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive.
With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive.   The relationship between enzymes and certain diseases The diseases caused by the lack of enzymes in the human body are mostly congenital or hereditary. For example, albinism is caused by the lack of tyrosine hydroxylase, and patients with broad bean disease or sensitivity to primaqui…

The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes.
The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes.   The development of restriction endonucleases In the early 1960s, Werner Arber came up with the idea that there was an enzyme that would cut the DNA of a virus, thereby limiting the virus' proliferation.…

Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. Since mitochondria play an important role in the maintenance of homeostasis, their abnormal function is associated with many human diseases, such as neurodegenerative diseases, cancer, heart disease and diabetes.
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed…

Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test item.
Principle of Luminex Multiplex Assay Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test item. The fluorescent coding microsphe…

PEG-linkers are particularly attractive as a linker for Antibody–drug conjugates (ADCs). Water solubility, lack of toxicity; low immunogenicity and well-defined chain lengths and molecular weights are specific characteristics of PEG moieties relevant to pharmaceutical applications
As the field of antibody-drug conjugation chemistry has advanced, the use of linkers to impart "drugability" has also been growing. Biopharma PEG  leapts at the opportunity to develp various high purity PEG derivatives used as ADC linkers. Antibody–drug conjugates (ADCs) or immunoconjugates have shown to offer the unique benefits of a targeted therapeutic strategy combined with the best features of both therapeutic monoclonal antibodies (mAb) and potent small-molecule cytotoxic drugs through a linke…

In this article, we’ve rounded up the best Pharmaceutical and Life Science workplaces for well-being in the UK, based on the official rankings given by The Great Place to Work Institute in 2022.
In this article, we’ve rounded up the best Pharmaceutical and Life Science workplaces for well-being in the UK, based on the official rankings given by The Great Place to Work Institute in 2022… Medium Workplaces (51-250 Employees) Alnylam (Pharmaceuticals) Anlylam is leading the translation of RNA interface into new innovative medicines with the aim to transform the lives of people affected by rare and prevalent diseases with unmet needs. Ranking 51st in the Medium Workplaces category, the company offers employee benefits including medical, dental and vision insurance as well as emotional health be…

In the UK, the number of job vacancies has now exceeded the number of people unemployed for the first time, and similar trends are being seen across the globe. Making your job adverts stand out against so many others is becoming tougher than ever, yet it’s not an impossible challenge. In this article, we look at 7 ways to improve your job advert SEO, helping you to continue to attract the best talent in the Life Science industry.
If you’re currently hiring within the Life Sciences sector and are struggling to get your job adverts seen, then it might be time to review your Search Engine Optimisation (SEO). In the UK, the number of job vacancies has now exceeded the number of people unemployed for the first time, and similar trends are being seen across the globe. Making your job adverts stan…

The pharmaceutical and biopharmaceutical industries have been seeing a trend towards single-use technologies. However, this new approach and the introduction and advance of personalized therapies are currently leading to massive supply-chain delays in terms of single-use consumables. Therefore, new solutions have to be found and companies have to think strategically and change up processes as soon as possible.
As there is an upward trend to single-use technologies, strategic thinking and the courage to change up processes are called for in the pharma industry. The pharmaceutical and biopharmaceutical industries are seeing a major shift to disposable technologies. However, this shift and the introduction and advance of personalized and allogeneic therapies are currently leading to massive su…