Articles
Enzyme engineering is a technology in which enzymes or microbial cells, animal and plant cells, organelles, etc. are placed in a certain biological reaction device, and the corresponding raw materials are converted into useful substances by using the biocatalytic function of enzymes and engineering methods.
Enzyme engineering is a technology in which enzymes or microbial cells, animal and plant cells, organelles, etc. are placed in a certain biological reaction device, and the corresponding raw materials are converted into useful substances by using the biocatalytic function of enzymes and engineering methods. It includes the preparation of enzyme preparations, the immobilization of enzymes, the modification and transformation of enzymes, and the content of enzyme reactors. The application…
Enzyme engineering is a technology in which enzymes or microbial cells, animal and plant cells, organelles, etc. are placed in a certain biological reaction device, and the corresponding raw materials are converted into useful substances by using the biocatalytic function of enzymes and engineering methods. It includes the preparation of enzyme preparations, the immobilization of enzymes, the modification and transformation of enzymes, and the content of enzyme reactors. The application…
In a usual drug packaging test project, the following factors should be tested, including identification, solution appearance, UV absorbance, pH, total organic carbon, bioreactivity tests for polyethylene, polypropylene, polyethylene terephthalate, cyclic olefins and plasticized polyvinyl chloride, as well as chemical safety assessments.
The packaging materials used for pharmaceutical tablets are in direct contact with the pharmaceuticals. Therefore, as a pharmaceutical manufacturer, when selecting packaging materials, it is necessary to understand some properties and characteristics of packaging materials and containers, to ensure the efficacy and quality of medicines. What are the common pharmaceutical packaging materials? Glass: Glass has the advantages of being moisture-proof, easy to s…
The packaging materials used for pharmaceutical tablets are in direct contact with the pharmaceuticals. Therefore, as a pharmaceutical manufacturer, when selecting packaging materials, it is necessary to understand some properties and characteristics of packaging materials and containers, to ensure the efficacy and quality of medicines. What are the common pharmaceutical packaging materials? Glass: Glass has the advantages of being moisture-proof, easy to s…
17-Mar-2022
In response to the pandemic, regulators accepted virtual audit inspections. Two years on, is remote auditing here to stay? Alasdair Leckie, Operations Manager at Rephine Ltd, reveals the findings of research among international pharma clients and senior auditors looking to the future of auditing.
Before the pandemic, the pharma industry and its regulators would not have entertained the concept of remote audits to verify that the manufacturing and distribution standards of supply-chain partners were being maintained. Even the suppliers themselves would not have expected to be monitored at distance. The last two years have changed that, as lockdowns, social distancing and travel restrictions disrupted normal conditions. Rather than curtail audits altogether, with potential risk to product qua…
Before the pandemic, the pharma industry and its regulators would not have entertained the concept of remote audits to verify that the manufacturing and distribution standards of supply-chain partners were being maintained. Even the suppliers themselves would not have expected to be monitored at distance. The last two years have changed that, as lockdowns, social distancing and travel restrictions disrupted normal conditions. Rather than curtail audits altogether, with potential risk to product qua…
13-May-2022
Locating and engaging hard-to-find talent in the Life Science industry is only getting tougher in today’s competitive job market. However, there are some simple things you can do to make your search for highly specialised, niche talent that little bit easier. In this article, we outline 10 ways to locate hard-to-find talent in the Life Science industry; from rewriting your job adverts and strengthening your employer brand, to making the most of social media and niche job boards.
Locating and engaging hard-to-find talent in the Life Science industry is only getting tougher in today’s competitive job market. However, there are some simple things you can do to make your search for highly specialised, niche talent that little bit easier. In this article, we outline 10 ways to locate hard-to-fin…
Locating and engaging hard-to-find talent in the Life Science industry is only getting tougher in today’s competitive job market. However, there are some simple things you can do to make your search for highly specialised, niche talent that little bit easier. In this article, we outline 10 ways to locate hard-to-fin…
Drug Regulatory Affairs, or DRAs, are responsible for icing that new medicines meet safety and efficacity norms. They also make sure that the medicine information is accurate and over to date before the medicine can be retailed.
What's Regulatory Affairs? Medicine Regulatory Affairs is the process of icing that medicines and medical bias are safe for public consumption. It includes the responsibility to insure that all products are manufactured in agreement with current Good Manufacturing Practices (GMP), to maintain records, and to report adverse events. Significance of Regulatory Affairs Medicine Regulatory Affairs is the process by which medicinals are estimated for safety and efficacity. It's an important part of the medicine development process, as it ensures that medicin…
What's Regulatory Affairs? Medicine Regulatory Affairs is the process of icing that medicines and medical bias are safe for public consumption. It includes the responsibility to insure that all products are manufactured in agreement with current Good Manufacturing Practices (GMP), to maintain records, and to report adverse events. Significance of Regulatory Affairs Medicine Regulatory Affairs is the process by which medicinals are estimated for safety and efficacity. It's an important part of the medicine development process, as it ensures that medicin…
How Cambridge biologics company SolasCure is developing an accessible method for cleaning chronic wounds, inspired by a solution from nature.
Maggot therapy, the unpleasant practice of introducing living fly larvae into wounds to remove dead and dying tissue, is astonishingly effective. Its popularity can be traced back to ancient cultures around the world[1]. For millennia people had observed that maggots were able to effectively clean wounds, but only in the 20th century was it possible to attempt to use them in a more systematic and deliberate way, as a "treatment". Due to their widely accepted efficacy, today maggots can be found in controlled clinical settings to clean chronic wounds, secreting digestive enzymes of which some specifically break down the fibrin networks found in necrot…
Maggot therapy, the unpleasant practice of introducing living fly larvae into wounds to remove dead and dying tissue, is astonishingly effective. Its popularity can be traced back to ancient cultures around the world[1]. For millennia people had observed that maggots were able to effectively clean wounds, but only in the 20th century was it possible to attempt to use them in a more systematic and deliberate way, as a "treatment". Due to their widely accepted efficacy, today maggots can be found in controlled clinical settings to clean chronic wounds, secreting digestive enzymes of which some specifically break down the fibrin networks found in necrot…
When recruiting within the Life Science industry, there is often an emphasis on what candidates can do in terms of hard skills and technical expertise. However, soft skills are becoming more important than ever in the industry, with recruiters now looking at how candidates could fit in with and contribute to the company culture as well as how long their list of qualifications and achievements is.
When recruiting within the Life Science industry, there is often an emphasis on what candidates can do in terms of hard skills and technical expertise. However, soft skills are becoming more important than ever in the industry, with recruiters now looking at how candidates could fit in with and contribute to the company culture as well as how long their list of qualifications and achievements is. W…
When recruiting within the Life Science industry, there is often an emphasis on what candidates can do in terms of hard skills and technical expertise. However, soft skills are becoming more important than ever in the industry, with recruiters now looking at how candidates could fit in with and contribute to the company culture as well as how long their list of qualifications and achievements is. W…
The CEO and COO of Siilo - Europe's largest medical messenger app - provide their personal insights into championing women in the health tech industry, ahead of this year's International Women's Day on 8 March.
Five ways a tech business can champion women in the workplace International Women’s Day (8 March) provides the ideal opportunity for employers in the healthtech sector to reassess gender diversity, according to Siilo CEO, Joost Bruggeman and COO, Esther Van Der Meer. Here both share their perspectives… Esther Van Der Meer: Any business which wants to fully meet the needs of its customers or end users needs to do everything possible to understand them – who they are, how they work and what they need. To achieve this, you simply must have a diverse employee base. It is…
Five ways a tech business can champion women in the workplace International Women’s Day (8 March) provides the ideal opportunity for employers in the healthtech sector to reassess gender diversity, according to Siilo CEO, Joost Bruggeman and COO, Esther Van Der Meer. Here both share their perspectives… Esther Van Der Meer: Any business which wants to fully meet the needs of its customers or end users needs to do everything possible to understand them – who they are, how they work and what they need. To achieve this, you simply must have a diverse employee base. It is…
25-Jan-2023
Germany is home to the largest Pharmaceutical market in Europe and the fourth largest in the world; with its large population, strong infrastructure and highly skilled workforce making it an ideal location for Pharmaceutical innovation. With a highly skilled workforce comes a lot of competition amongst Pharmaceutical and Life Science recruiters for the best talent in the industry, which is a challenge that has only been made more difficult post-pandemic.
Germany is home to the largest Pharmaceutical market in Europe and the fourth largest in the world; with its large population, strong infrastructure and highly skilled workforce making it an ideal location for Pharmaceutical innovation. With a highly skilled workforce comes a lot of competition amongst Pharmaceutical and Life Science recrui…
Germany is home to the largest Pharmaceutical market in Europe and the fourth largest in the world; with its large population, strong infrastructure and highly skilled workforce making it an ideal location for Pharmaceutical innovation. With a highly skilled workforce comes a lot of competition amongst Pharmaceutical and Life Science recrui…
The demand for therapeutic proteins is constantly growing and gives further reason for continuing the development of high-quality protein production technologies. Mammalian cell lines are the preferred choice to create recombinant proteins, in particular Chinese Hamster Ovary (CHO) cells and Human Embryonic Kidney (HEK or HEK293) cells.
However, with the higher demand also comes a higher confusion of which cell line to pick for one’s own studies. Due to the many possibilities as well as advantages and disadvantages, it can be quite troubling to decide which cells would serve specific research the best. Therefore, this article is designed to help scientists make the right choice.
HEK cells vs. CHO cells in recombinant antibody production: What's the better choice The demand for therapeu…
HEK cells vs. CHO cells in recombinant antibody production: What's the better choice The demand for therapeu…
22-Apr-2022
With thousands of new jobs being advertised across the Life Science industry every day, it can be difficult to know where to start looking for the next step in your career. In this article, we’ve put together some key things you can do to help with your Life Science job search; with advice on what you can do both before and during your search to get the best results from your time.
With thousands of new jobs being advertised across the Life Science industry every day, it can be difficult to know where to start looking for the next step in your career. In this article, we’ve put together some key things you can do to help with your Life Science job search; with advice on what you can do both before and during your search to get the best results from your time… Focus Your Job Search Before di…
With thousands of new jobs being advertised across the Life Science industry every day, it can be difficult to know where to start looking for the next step in your career. In this article, we’ve put together some key things you can do to help with your Life Science job search; with advice on what you can do both before and during your search to get the best results from your time… Focus Your Job Search Before di…
01-Apr-2022
15 Pharma and Life Science events taking place in March 2022, including events on drug development, gene therapy, drug safety, regulatory affairs, pharma supply chains, digitalisation and transformation, and more.
15 Pharma and Life Science events taking place in March 2022: 2nd Interstitial Lung Disease Drug Development Summit (March 7th-9th) The timely 2nd ILD Summit will siphon critical insights from experts at Pfizer, Genentech, Novartis, Boehringer Ingelheim and Pieris Pharmaceuticals to help you catalyze a new wave of therapies against Scleroderma, Sarcoidosis, COP, CT-ILDs and more. Gene Therapy for Rare Disorders 2022 (March 7th-10th) As the gene therapy field strives to strike the balance between clinical efficacy and product safety in the context of mounting regulatory scrutiny, G…
15 Pharma and Life Science events taking place in March 2022: 2nd Interstitial Lung Disease Drug Development Summit (March 7th-9th) The timely 2nd ILD Summit will siphon critical insights from experts at Pfizer, Genentech, Novartis, Boehringer Ingelheim and Pieris Pharmaceuticals to help you catalyze a new wave of therapies against Scleroderma, Sarcoidosis, COP, CT-ILDs and more. Gene Therapy for Rare Disorders 2022 (March 7th-10th) As the gene therapy field strives to strike the balance between clinical efficacy and product safety in the context of mounting regulatory scrutiny, G…
01-Mar-2022
With the growing popularity of Paxlovid, the second spring of caronic anhydride has arrived, one the key intermediates of Paxlovid.
On February 16, 2022, the data on Paxlovid previously published by Pfizer and submitted to the FDA were published in the New England Journal of Medicine (NEJM). This NEJM article published viral load data that Paxlovid reduced viral load by 0.868 log10 compared to controls for 5 days of treatment, which equates to a remarkable 7.38-fold reduction in viral load. This pivotal study (NCT04960202) enrolled 2,246 patients with COVID-19, 1,120 received Paxlovid and 1,126 received placebo. Interim analysis showed that 28 days after receiving treatment, Paxlovid reduced the risk of hospitalization and death by 89.1% (p<0.001). Applying the final results of the IT…
On February 16, 2022, the data on Paxlovid previously published by Pfizer and submitted to the FDA were published in the New England Journal of Medicine (NEJM). This NEJM article published viral load data that Paxlovid reduced viral load by 0.868 log10 compared to controls for 5 days of treatment, which equates to a remarkable 7.38-fold reduction in viral load. This pivotal study (NCT04960202) enrolled 2,246 patients with COVID-19, 1,120 received Paxlovid and 1,126 received placebo. Interim analysis showed that 28 days after receiving treatment, Paxlovid reduced the risk of hospitalization and death by 89.1% (p<0.001). Applying the final results of the IT…
At present, there are 9 drugs in 5 categories of anti-influenza drugs approved for marketing by national drug regulatory authorities worldwide.
Each year, seasonal influenza pandemics can result in 3-5 million severe cases and 290,000-650,000 respiratory disease-related deaths worldwide. So far, there are five documented influenza pandemics: ① 1918 H1N1 influenza in Spain; ② 1957 H2N2 influenza in Asia; ③ 1968 H3N2 influenza in Hong Kong, China; ④ 2005 H1N1 avian influenza; ⑤ 2009 H1N1 influenza. At present, there are 9 drugs in 5 categories of anti-influenza drugs approved for marketing by national drug regulatory authorities worldwide: ① M2 ion channel inhibitors amantadine and rimantadine; ② Neuraminidase inhibitors zanamivir, oseltamivir, peramivir, and laninamivir; ③RNA-depen…
Each year, seasonal influenza pandemics can result in 3-5 million severe cases and 290,000-650,000 respiratory disease-related deaths worldwide. So far, there are five documented influenza pandemics: ① 1918 H1N1 influenza in Spain; ② 1957 H2N2 influenza in Asia; ③ 1968 H3N2 influenza in Hong Kong, China; ④ 2005 H1N1 avian influenza; ⑤ 2009 H1N1 influenza. At present, there are 9 drugs in 5 categories of anti-influenza drugs approved for marketing by national drug regulatory authorities worldwide: ① M2 ion channel inhibitors amantadine and rimantadine; ② Neuraminidase inhibitors zanamivir, oseltamivir, peramivir, and laninamivir; ③RNA-depen…
25-Mar-2022
The Biotechnology industry is currently thriving, with the global Biotechnology market value predicted to reach $727.1 billion by 2025. In the US alone, there are more than 800,000 people employed in the Biotech industry, with the employment rate expected to grow by 5% between 2019 and 2029. In this article, we summarise 10 career paths within Biotechnology, with an outline of each role’s key responsibilities.
The Biotechnology industry is currently thriving, with the global Biotechnology market value predicted to reach $727.1 billion by 2025. In the US alone, there are more than 800,000 people employed in the Biotech industry, with the employment rate expected to grow by 5% between 2019 and 2029. New roles within the industry are continuously being created across the globe, particularly in…
The Biotechnology industry is currently thriving, with the global Biotechnology market value predicted to reach $727.1 billion by 2025. In the US alone, there are more than 800,000 people employed in the Biotech industry, with the employment rate expected to grow by 5% between 2019 and 2029. New roles within the industry are continuously being created across the globe, particularly in…
The LEGO Foundation has announced it will donate 600 LEGO® MRI Scanners to hospitals worldwide to help children cope with the uncertainty of having a Magnetic Resonance Imaging (MRI) scan. What started in 2015 as a passion project for LEGO employee Erik Ullerlund Staehr and Odense University Hospital, Denmark, is now being scaled and piloted with new training material for hospital staff.
Radiology departments worldwide encouraged to apply Billund, Denmark, 23 February 2022 – The LEGO Foundation has announced it will donate 600 LEGO® MRI Scanners to hospitals worldwide to help children cope with the uncertainty of having a Magnetic Resonance Imaging (MRI) scan. What started in 2015 as a passion project for LEGO employee Erik Ullerlund Staehr and Odense University Hospital, Denmark, is now b…
Radiology departments worldwide encouraged to apply Billund, Denmark, 23 February 2022 – The LEGO Foundation has announced it will donate 600 LEGO® MRI Scanners to hospitals worldwide to help children cope with the uncertainty of having a Magnetic Resonance Imaging (MRI) scan. What started in 2015 as a passion project for LEGO employee Erik Ullerlund Staehr and Odense University Hospital, Denmark, is now b…
Covid-19 has impacted virtually everyone‘s lives, whether through personal experience of infection or the impacts of other people’s illness. But how is Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) able to enter our cells? The answer lies in the external part of the angiotensin-converting enzyme 2 (ACE2) receptor protein, which is present in a wide range of cells throughout the body and acts as a gateway for the virus.
Covid-19 has impacted virtually everyone‘s lives, whether through personal experience of infection or the impacts of other people’s illness. But how is Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) able to enter our cells? The answer lies in the external part of the angiotensin-converting enzyme 2 (ACE2) receptor protein, which is present in…
Covid-19 has impacted virtually everyone‘s lives, whether through personal experience of infection or the impacts of other people’s illness. But how is Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) able to enter our cells? The answer lies in the external part of the angiotensin-converting enzyme 2 (ACE2) receptor protein, which is present in…
As part of our Diversity, Equity & Inclusion Leadership series, we spoke to Corinne Le Goff, until recently Chief Commercial Officer at Moderna, a pioneer in mRNA therapeutics and developer of the second mRNA COVID-19 vaccine to be approved.
“…I believe that specifically in healthcare, diversity is hugely important. The most critical value of diversity in healthcare is to improve patient outcomes…” As part of our Diversity, Equity & Inclusion Leadership series, we spoke to Corinne Le Goff, until recently Chief Commercial Officer at Moderna, a pioneer in mRNA therapeutics and developer of the second mRNA COVID-19 vaccine to be approved. Corinne brings over 30 years’ experience in pharmaceuticals, having held senior strategic and commercial leadership roles at Amgen, Roche, Merck AG and…
“…I believe that specifically in healthcare, diversity is hugely important. The most critical value of diversity in healthcare is to improve patient outcomes…” As part of our Diversity, Equity & Inclusion Leadership series, we spoke to Corinne Le Goff, until recently Chief Commercial Officer at Moderna, a pioneer in mRNA therapeutics and developer of the second mRNA COVID-19 vaccine to be approved. Corinne brings over 30 years’ experience in pharmaceuticals, having held senior strategic and commercial leadership roles at Amgen, Roche, Merck AG and…
In microbial ecology, metagenomic techniques are now widely utilized to research microbial communities in greater depth, including many strains that cannot be produced in the lab. Microbial bioinformatics may now be used to mine large metagenomic datasets for broad patterns that govern microbial communities. Typical metagenomic and bioinformatic investigations, on the other hand, do not fully characterize the ecology and evolution of microorganisms in their habitats. The majority of analyses still rely on basic sequence similarity searches against reference databases.
Introduction to Bioinformatics for Microbial Metagenomics In microbial ecology, metagenomic techniques are now widely utilized to research microbial communities in greater depth, including many strains that cannot be produced…
Introduction to Bioinformatics for Microbial Metagenomics In microbial ecology, metagenomic techniques are now widely utilized to research microbial communities in greater depth, including many strains that cannot be produced…
22-Feb-2022
It is of great significance to study the stability of pharmaceutical preparations to ensure product quality, safety, and effectiveness.
The basic requirements of pharmaceutical preparations are safety, efficacy, and stability. Drug stability means that a drug product should maintain the same properties and characteristics as it was at the time of production and within the specified time frame. The stability of pharmaceutical preparations directly affects the effectiveness and safety of drugs. Therefore, it is of great significance to study the stability of pharmaceutical preparations to ensure product quality, safety, and effectiveness. Research Scope on Drug Stability Analysis Chemical stability refers to changes in drug content (or potency) due to chemical reactions such as hydrolysis and…
The basic requirements of pharmaceutical preparations are safety, efficacy, and stability. Drug stability means that a drug product should maintain the same properties and characteristics as it was at the time of production and within the specified time frame. The stability of pharmaceutical preparations directly affects the effectiveness and safety of drugs. Therefore, it is of great significance to study the stability of pharmaceutical preparations to ensure product quality, safety, and effectiveness. Research Scope on Drug Stability Analysis Chemical stability refers to changes in drug content (or potency) due to chemical reactions such as hydrolysis and…
