Articles

Probiotics are a class of active microorganisms that are beneficial to the host. They are the general term for active beneficial microorganisms that colonize the human intestine and reproductive system and can produce definite health effects to improve the host's micro-ecological balance and play a beneficial role. The beneficial bacteria or fungi in humans and animals mainly include: Clostridium butyricum, Lactobacillus, Bifidobacterium, Actinomyces, yeast, etc. At present, the most powerful products are mainly compound active probiotics composed of the above types of microorganisms, which are widely used in the fields of bioengineering, industry and agriculture, food safety and life and health.
Probiotics are a class of active microorganisms that are beneficial to the host. They are the g…

What are the influences on Quality Management today? And what does the future hold for Quality in the era of smart automation? Late last year, James Kelleher, CEO of Generis, chaired a discussion of experts from Merck, Syneos Health and Accenture.
What are the influences on Quality Management today? And what does the future hold for Quality in the era of smart automation? Late last year, James Kelleher, CEO of Generis, chaired a discussion of experts from Merck, Syneos Health and Accenture. Taking part were: Dr. Heiner Niessen, Head of Application Technology Quality & Compliance at Merck Peter Brandstetter, Quality and Regulatory expert at Accenture James Man, Quality subject expert and R&D Advisory Managing Director at Syneos Health. Here are the edited highlights. Is the era of…

Excipients are designed to interact with and enhance the properties of APIs. Excipients have various functions.
Pharmaceutical excipients are substances formulated together with active pharmaceutical ingredients (APIs) of the drug, and excipients account for most of the drug composition. Excipients are designed to interact with and enhance the properties of APIs. Excipients have various functions. In addition to acting as carriers, and improving stability, pharmaceutical excipients are also conducive in terms of solubilization, sustained release, and controlled release. Overall, they are important components that may affect the quality, safety and effectiveness of drugs. Excipients can be classified by source, function, route of administration, and the like. By Source They can be divided in…

To help you prepare for your next pharma job interview, we’ve put together this list of 36 questions to ask yourself prior to the interview, with ways to prepare for both in-person and virtual job interviews.
Download the checklist here. About the Interview [  ] Do you know who your interview is with? [  ] Have you done some research on your interviewer(s)? [  ] Do you know where the interview is taking place? Is it in-person or virtual? [  ] Do you know how long the interview is for? [  ] Do you know the format of the interview? E.g., is it a one-to-one, panel interview, assessment centre, or presentation? [  ] Have you researched and rehearsed some commonly asked interview questions? [  ] Have you prepared some questions of your own to ask the interviewer? [  ] Have you read over your CV…

The following discussion is based on the requirements described in the EU Guideline on Good Distribution Practice of medicinal products for human use, however, the GDP Guidelines for active substances, the GMP Guidelines and similar regulations contain comparable requirements for the respective areas within or outside of the EU.
Legal and regulatory requirements, including GMP and GDP guidelines, require consistently that medicinal products shall be stored and transported in a way that the product delivered maintain their quality and integrity and remain within the legal supply chain during storage and/or transportation. Storage and transport need to be described in the Pharmaceutical Quality System and the principles of quality risk management shall be used for designing and managing these…

A strong commercialization strategy is vital to a successful launch and uptake in any geography, but especially in the EU market, where pricing and reimbursement decisions are decentralized, complex, and dynamic. A commercialization strategy for the EU needs to account for the unique pricing and reimbursement approaches for the individual country markets. The strategy used in our case is referred to as international reference pricing (IRP) which is the practice of informing price negotiations in a given country by calculating a benchmark, or reference, price based on publicly available pricing data from one or more other countries.
Launching a new molecular entity (NME) has always been an uncertain endeavor for the pharmaceutical industry. To do so, one must successfully address seemingl…

Understanding the forecasting process and making decisions based on those predictions is not done easily. Without time-machines or real fortune tellers to give us the answers of what will happen, we’re left with the practice of modeling the future, and subsequently base our decisions on what those models tells us. As these results provide the basis for our decisions, the models must be sufficiently realistic and describe the most important components of the decision reality.
Understanding the forecasting process and making decisions based on those predictions is not done easily. Without time-machines or real fortune tellers to give us the answers of what will happen, we’re left with the practice of modeling the future, and subsequently base our decisions on what those models tells us. As th…

The Life Science job market is becoming even more competitive and candidate-driven in 2022. With The Great Resignation already making an impact in the industry, and with 67% of candidates feeling either confident or very confident with finding a new employer, improving your employee retention this year should be a priority.
The Life Science job market is becoming even more competitive and candidate-driven in 2023. With The Great Resignation already making an impact in the industry, and with 67% of candidates feeling either confident or very confident with finding a new employer, improving your employee retention this year should be a priority. In this article, we outline 8 things you can do to improve your employee retention in 2023, focusing on what you can do beyond offering a competitive…

A strong commercialization strategy is vital to a successful launch and uptake in any geography, but especially in the EU market, where pricing and reimbursement decisions are decentralized, complex, and dynamic. A commercialization strategy for the EU needs to account for the unique pricing and reimbursement approaches for the individual country markets. The strategy used in our case is referred to as international reference pricing (IRP) which is the practice of informing price negotiations in a given country by calculating a benchmark, or reference, price based on publicly available pricing data from one or more other countries.
Launching a new molecular entity (NME) has always been an uncertain endeavor for the pharmaceutical industry. To do so, one must successfully address seemingl…

PharmiWeb.Jobs is delighted to welcome Clinigen Healthcare to our job board. Clinigen Healthcare in their own words...
Clinigen Healthcare in their own words... Clinigen exists to make sure a healthcare professional with a patient in need, anywhere in the world, can always get the right medicine for their individual patient – quickly, easily and safely whether licensed or unlicensed. We’re a rapidly growing company with a bright future ahead. To sustain this growth, we’re always on the lookout for motivated, ambitious, and committed individuals to join our team. Click here to view Clinigen Healthcare jobs

Even before the Covid pandemic struck there were signs of significant growth in the UK in vitro diagnostics industry. 2019, the last year for which figures are available, saw its market increase by 3.1%, compared with a rise of just 0.3% in France and a fall of 0.4% in Germany, its nearest competitors.
Having reached the Premier League, the UK diagnostics industry must now avoid relegation     By Ivor Campbell Even before the Covid pandemic struck there were signs of significant growth in the UK in vitro diagnostics industry. 2019, the last year for which figures are available, saw its market increase by 3.1%, compared with a rise of just 0.3% in France and a fall of 0.4% in Germany, its nearest competitors. A significant component was instruments and consumables, while there…

Filling roles by implementing an internal mobility strategy for your organisation can be a cost-effective way of filling critical skills gaps, whilst boosting your employee retention and reducing turnover rates. In this article, we outline some of the key benefits of internal mobility, along with advice on how to get the most out of your internal mobility strategy.
Internal mobility describes the movement of employees within an organisation from one role to another. There are two types: Lateral mobility is where an employee takes on a new role at the same level as their current role, usually with different responsibilities or in a different business area Vertical mobility is where an employee tales on a new role at a level above their current role, usually with additional responsibility F…

High blood pressure is typically experienced by older people(1). You may have it but do not feel the severe symptoms. However, it may cause other severe problems, such as heart diseases, eye problems, stroke, and kidney failure(2). Some alternative ways to deal with high blood pressure include managing stress, stretching exercises, doing yoga, and a healthy diet...
High blood pressure is typically experienced by older people(1). You may have it but do not feel the severe symptoms. However, it may cause other severe problems, such as heart diseases, eye problems, stroke, and kidney failure(2). Some alternative ways to deal with high blood pressure include managing stress, stretching exercises, doing yoga, and a healthy diet. High Blood Pressure and Your Feet One complication associated with…

NHS professionals make millions of health and care decisions every single day. The challenge of ensuring these decisions are based on the latest insight, married with decades of evidence and research, is being met head-on with the arrival of a brand-new online search.
Healthcare evidence and knowledge now a simple search away   NHS professionals make millions of health and care decisions every single day. The challenge of ensuring these decisions are based on the latest insight, married with decades of evidence and research, is being met head-on with the arrival of a brand-new online search.   The Health Education England funded NHS Knowledge and Library Hub is a ‘one-stop’ national gateway which, for the first time nationally, connects healthcare staff and trainees seamlessly to…

If a crisis is recognised, it can be a powerful accelerator of change. But do we always spot a crisis when we see it? Often there needs to be a key event (or series of events) to highlight the situation and signal that a turning point has been reached. Here are three crises—two that have been widely seen, and a third that needs more attention.
Crises can’t be dealt with until they are recognised By Robert Hewitt, MB BS, PhD, Biosample Hub If a crisis is recognised, it can be a powerful accelerator of change. But do we always spot a crisis when we see it? Often there needs to be a key event (or series of events) to highlight the situation and signal that a turning point has been reached. Here are three crises—two that have been widely seen, and a third that needs more attention. A Quality Cr…

The life sciences industry has evolved tremendously with the acceleration of technology, and digital development presents many opportunities for research and overall process improvements. As we continue to innovate and imagine the future, our annual summit Breakthrough was an insightful look into the technology and upcoming trends of life sciences.
The life sciences industry has evolved tremendously with the acceleration of technology, and digital development presents many opportunities for research and overall process improvements. As we continue to innovate and imagine the future, our annual summit Breakthrough was an insightful look into the technology and upcoming trends of life sciences. Over two days,  leaders from established pharma and emerging biotechs discussed the outlook fo…

Cellulase (β-1,4-glucan-4-glucanohydrolase) is a general term for a group of enzymes that degrade cellulose to produce glucose. Cellulase is a kind of complex enzyme, including C1 enzyme, CX enzyme and glucosidase and other components. Among them, C1 enzyme and CX enzyme can decompose cellulose into cellobiose, and glucosidase can decompose cellobiose into glucose, thereby providing nutrients for the growth and development of microorganisms.
Cellulase (β-1,4-glucan-4-glucanohydrolase) is a general term for a group of enzymes that degrade cellulose to produce glucose. Cellulase is a kind of complex enzyme, including C1 enzyme, CX enzyme and glucosidase and other components. Among them, C1 enzyme and CX enzyme can decompose cellulose into cellobiose, and glucosidase can decompose cellobiose i…

How does life appear on earth? This has always been an unsolved mystery. According to the Physicists Organization Network, Canadian researchers published a report in the latest issue of Science that an RNA polymerase played an important role in the birth of life on earth. The new research provides new insights into the mystery of the origin of life on earth, and also helps scientists estimate the possibility of life being born on other planets.
How does life appear on earth? This has always been an unsolved mystery. According to the Physicists Organization Network, Canadian researchers published a report in the latest issue of Science that an RNA polymerase played an important role in the birth of life on earth. The new research provides new insights into the mystery of the origin of life o…

Chymotrypsin is a typical serine protease. As an endopeptidase that catalyzes the hydrolysis of protein peptide bonds, its realization form is mainly for the cleavage of the peptide bond formed by the carboxyl end of the aromatic amino acid-tryptophan, phenylalanine or tyrosine. Chymotrypsin is a typical serine protease and is currently one of the digestive enzymes of most vertebral animals.
Chymotrypsin is a typical serine protease. As an endopeptidase that catalyzes the hydrolysis of protein peptide bonds, its realization form is mainly for the cleavage of the peptide bond formed by the carboxyl end of the aromatic amino acid-tryptophan, phenylalanine or tyrosine. Chymotrypsin is a typical serine protease and is currently one of the digestive enzymes of most vertebral animals.   Simi…

2021 has been a turbulent year, and one that many of us are very pleased to see the back of – but among the uncertainty and constant change, it gave rise to new methods of working for countless people and industries across the globe. Against this backdrop, medical device organisations have had to prepare themselves for compliance deadlines and adapt to new technologies. Looking ahead now, the busy period doesn’t appear to be going away anytime soon.
Future focus: The three tech trends helping medical device organisations go digital in 2022 Bob Tilling, VP Global Sales, Kallik 2021 has been a turbulent year, and one that many of us are very pleased to see the back of – but among the uncertainty and constant change, it gave rise to new methods of working for countless people and industries a…