Articles

Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. Microbiomes from depressed patients were transplanted into rats, which developed similar mental health problems.
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs.…

Single-nucleotide polymorphisms (SNPs) are a kind of DNA polymorphisms caused by single-nucleotide variants in both coding and non-coding regions, which are the most common and smallest variants. There are more than 3 million SNPs in the human genome with an average of 1 in 500-1000 base pairs. SNP microarrays are capable of detecting a large number of subtle DNA alterations and/or abnormal alterations related to chromosome copy number (aneuploidy) or chromosome structural rearrangements. In human species, SNP microarrays can simultaneously analyze all 23 chromosome pairs and can also be used to identify mutations in individual genes. In addition, SNPs can be used for genotyping, i.e., determining the proportion of each allelic variant combination at each nucleotide position.
Single-nucleot…

The development of DNA sequencing technology has made it possible for human beings to explore the mysteries of themselves and other beings, while the advent of the genomics era has put higher demands on sequencing technologies. Scientific research has now entered the era of high throughput, moving from single, localized genes or fragments to the study of the entire genome, covering basic science, disease diagnosis and treatment, agriculture and the environment.
The development of DNA sequencing technology has made it possible for human beings to explore the mysteries of themselves and other beings, while the advent of the genomics era has put higher demands on sequencing technologies. Scientific research has now entered the era of high throughput, moving from single, localized genes or frag…

The epigenome is composed of chemical markers and proteins that can attach to DNA and direct the function of gene regulatory elements, controlling the production of proteins in specific cells, among other roles. Common epigenomic modifications include methylation of the nucleotide cytosine and histones or acetylation and phosphorylation of histones. All of these modifications do not change the genome sequence, but they do change the way the cell uses the same set of genetic codes, thus altering phenotypes and metabolic activities. The epigenome is also inheritable.
The epigenome is composed of chemical markers and proteins that can attach to DNA and direct the function of gene regulatory elements, controlling the production of proteins in specific cells, among other roles. Common epigenomic…

Automation Testing Training helps demonstrate how helpful automation testing is to developers. Firstly, it doesn’t need any type of human intervention.
Advantages of Automation Testing tools learnt in Automation Testing Training Automation Testing Training helps demonstrate how helpful automation testing is to developers. Firstly, it doesn’t need any type of human intervention. Secondly, there is no restriction on how many times on the number of automation test. Thirdly, it minimizes the cost of testing. Finally, Automation testing can be run at any time of the day. Therefore, Automation Testing training helps students discover different tools. Challenges outlined during Automation Testing Training. There are different challenges that are outlined during the duration of Automation Testing…

Amylase is a general term for enzymes that hydrolyze starch and glycogen with the specificity of enzyme preparation. Its main mechanism of action is to hydrolyze starch into maltose, glucose, dextrin, etc. To understand amylase, we must first understand starch, which is a storage polysaccharide stored in cells as starch granules during plant growth, and exists in seeds and tubers. Starch is not a simple molecule, but a mixture of two different types of starch, divided into two categories: amylose and amylopectin.
Amylase is a general term for enzymes that hydrolyze starch and glycogen with the specificity of enzyme preparation. Its main mechanism of action is to hydrolyze starch into maltose, glucose, dextrin, etc. To understand amylase, we must first understand starch, which is a storage p…

CRISPR/Cas9 gene editing technology has been widely used in many fields since its inception. Gene therapy developed using this technology has huge prospects in the medical and health fields. CRISPR/Cas9 technology enables gene-editing of the genome at specified sites, but a common worry about the technology is that gene-editing occurs where it shouldn't.
CRISPR/Cas9 gene editing technology has been widely used in many fields since its inception. Gene therapy developed using this technology has huge prospects in the medical and health fields. CRISPR/Cas9 technology enables gene-editing of the genome at specified sites, but a common worry about the technology is that gene-editing occurs where it shouldn't. In recent years, researchers at the University of Bath and Cardiff University in the UK…

Peroxidase, usually derived from horseradish, is a common enzyme used in clinical testing reagents. It is widely used not only in several biochemical assays but also in immunoassay (ELISA) kits. As a key component of the color development system of several kits, peroxidase has an important impact on the quality of the kits.
Peroxidase, usually derived from horseradish, is a common enzyme used in clinical testing reagents. It is widely used not only in several biochemical assays but also in immunoassay (ELISA) kits. As a key component of the color development system of several kits, peroxidase has an important impact on the quality of the kits.   Horseradish peroxidase (HRP) is the most commonly used enzyme because of its high activity, stability, small molecular weight and easy prepara…

Penicillinase is an enzyme that acts on the β-lactam ring of penicillin to convert penicillin into penicillic acid, which has no antibacterial activity. A variety of penicillin-resistant bacteria can produce this enzyme, such as the penicillin-resistant strains of Staphylococcusaureus and the penicillin-resistant strains of Bacillus cereus. This enzyme is a medical enzyme suitable for the treatment of allergic reactions to penicillin in general, and can also be used as an adjunctive treatment for patients with anaphylaxis or severe penicillin allergic reactions. Bacillus cereus can be used as a production strain of this enzyme.
Penicillinase is an enzyme that acts on the β-lactam ring of penicillin to convert penicillin into penicillic acid, which has no antibacterial activity. A variety of…

With the UK’s Clinical Research industry booming, and with the current job market becoming increasingly candidate-driven, 2022 is an excellent time to be considering a career move within or into Clinical Research. Following on from our previous article outlining 10 Clinical Research career paths, we’ve used Indeed’s Salary Guide to put together this list of the average base salary in the UK for these 13 common Clinical Research roles.
Clinical Research in England alone is worth approximately £2.7 billion a year. In March 2021, the UK government published its vision aimed at propelling the UK Clinical Research industry into the future. 5 key themes underpin this vision: Streamlined, efficient and innovative research Clinical research embedded in the NHS Patient-centred research Research ena…

At Amplexor BE THE EXPERT 2022, Remco Munnik of Iperion - a Deloitte business, took the example of product labeling to highlight the overlap between documents and data, and how internationally-agreed standards can contribute to a more streamlined approach to (and beyond) regulatory information management – from early development through to pharmacovigilance.
Although the value of developing more data-driven processes is now widely recognized, many life sciences organizations today still routinely create critical documents and product labeling from scratch. This involves capturing and applying the same information repeatedly, yet often in different formats and using inconsistent terminology. At Amplexor BE THE EXPERT 2022, Remco Munnik of Iperion - a Deloitte business, took the example of pr…

Whilst Pharma job promotions undoubtedly bring with them numerous benefits both personally and professionally, politely declining a promotion is valid if the new role just isn’t going to work for you. In this article, we outline 8 reasons why you may want to turn down a job promotion; addressing some of the main concerns when it comes to making changes in your career, and laying out advice on what you could do before making the decision to say no.
After falling 7.4% in 2020, promotions among professional workers in the US shot up by 9% in 2021, and this increase is also being recognised in job markets across the globe. Whilst many Pharma and Life Science employees are still fighting for the promotions they missed out on during the pandemic, these opportunities aren’t a priority for everyone…

At Amplexor Life Sciences’ BE THE EXPERT 2022 conference, Dr. Thierry Dietrich of pharm@dviser, discussed the different levels of cloud use and the best approaches to ensuring compliance in each case, as regulators pay closer attention to cloud-based data management.
As pharmaceutical companies become more confident and ambitious in their use of the cloud to host, run and source applications, more recently extending the model to regulated applications, important considerations arise - particularly around associated systems validation and data governance. At Amplexor Life Sciences' BE THE EXPERT 2022 conference, Dr. Thierry Dietrich of pharm@dviser, discussed the different levels of cloud use and the best approaches to ensuring compliance in each case, as regulators pay closer attention to c…

With over 15 years of experience across their senior leadership team, The Global Life Science Hub provides functional services and consulting with a solid mission to accelerate, strengthen and enhance global clinical trials.
Introducing GLS With over 15 years of experience across their senior leadership team, The Global Life Science Hub provides functional services and consulting with a solid mission to accelerate, strengthen and enhance global clinical trials. Financially backed by specialist head-hunting firm AL Solutions, they are primed to continue the growth and development of the Clinical Development and Biometrics sectors with the support of AL2S3 to effectively expand their functional services globally. The Global Life Science Hub strives to ensure that all their clinical research c…

“I like the excitement of not knowing what’s going to happen and I think I thrive on it.” For the first interview in our Human Strategy Series,  the team recently spoke with Dr Jackie Ameri, CEO of Pancryos, who benefited from our Leadership Assessment service as part of the partnership between Coulter Partners and the BioInnovation Institute (BII). Jackie discusses her early career, her decision to join the BII and highlights the benefits of being part of the BII Creation House Program.
“I like the excitement of not knowing what’s going to happen and I think I thrive on it.” For the first interview in its Human Strategy Series,  the Coulter Partners team recently spoke with Dr Jackie Ameri, CEO of Pancryos, who benefited from our Leadership Assessment service as part of the partner…

In the seventh interview in its Diversity, Equity & Inclusion Leadership series, Coulter Partners spoke to Tomoko Adachi, General Manager of Global HR and HR Business Partner for the Cardiac and Vascular Company at Terumo Corporation. Tomoko shares her insights in good D, E & I practice from her recent experience in medtech and compares this with what she has seen in the tech world, drawing on her 29-year tenure with Sony before Terumo.
“… For us to drive innovation that addresses the diverse healthcare needs of our global society, we need a diverse team…” --- In the next interview in our Diversity, Equity & Inclusion Leadership series, we spoke to Tomoko Adachi, General Manager of Global HR and HR Business Partner for the Cardiac and Vascular Company at Terumo Corporation. Tomoko share…

Already experts in the area of ophthalmology, Santen decided to harness the potential of cell and gene therapies (CGTs) to address unmet needs and change the lives of patients living with inherited retinal disorders (IRDs).
Solving the leading cause of inherited blindness Already experts in the area of ophthalmology, Santen decided to harness the potential of cell and gene therapies (CGTs) to address unmet needs and change the lives of patients living with inherited retinal disorders (IRDs). The recently established Santen Cell & Gene is a global business unit that is dedicated to changing patient lives through transformative solutions. Founded in Japan over a century ago, Santen has been contributing to people’s eye health for the past 130 years and has expanded to cover over 60 count…

A 2021 Mercer survey reported that 87% of life science companies were planning to offer part-time remote working models in the future. In 2022, remote working opportunities across the industry are continuously rising, with companies such as IQVIA, Worldwide Clinical Trials and Syneos Health advertising homeworking roles across the globe. To make homeworking work for you, we’ve outlined 12 things you can do to optimise your work from home space.
A 2021 Mercer survey reported that 87% of life science companies were planning to offer part-time remote working models in the future. In 2022, remote working opportunities across the industry are continuously rising, with companies such as IQVIA, Worldwide Clinical Trials and Syneos Health advertising homeworking roles across the globe.   Whether y…

Human pulmonary cells, a mainstay of many medical research labs, have acquired new relevance in the era of COVID-19. As the SARS-CoV-2 virus causes serious complications most commonly in the lungs, human primary pulmonary cells have become increasingly important in the study of this coronavirus strain.
The human respiratory system is composed of a network of tissues and organs that enable the body to absorb oxygen from the air as well as expel carbon dioxide and other waste gasses. These functions are supported by a variety of cells that aid in promoting epithelial homeostasis, preventing alveolar collapse, facilitating the exchange of gasses between the blood and the tissues, and ensuring that the lungs adjust properly to low atmospheric pressure. Primary cells taken directly from the resp…

In short, different diseased PBMCs were used for a wide variety of immunology-based applications, including in vitro immunoassays, population characterization, sequencing studies, and biologic testing as above. However, in the application process, attention should be paid to the quality stability, ethical issues of traceability, whether the cells are fresh, the selection of appropriate cells for different studies, etc.
Brief Introduction to PBMCs Peripheral Blood Mononuclear Cells (PBMC), also called Human Mononuclear Cells from Peripheral Blood (HMNC-PB), are cells with a single, round nucleus that are collected from peripheral or circulating blood. These blood cells are a key component in the immune system to fight infections and disease, adapting to invaders. PBMCs resp…