Articles

Understanding what decisions to make about the future is no easy task. In an earlier article, we outlined the 6 best practices in pharma decision-making, activities crucial to making the decision process efficient, less time-consuming, and more accurate. As the current situation is, the processes commonly used to manage data for forecasting purposes offer significant opportunities for improvement.
Understanding what decisions to make about the future is no easy task. In an earlier article, we outlined the 6 best practices in pharma decision-making, activities crucial to making the decision process efficient, less time-consuming, and more accurate. As the current situation is, the processes commonly used to manage data for forecasting purposes offer significant opportunities for improvement.…

In the workplace, burnout can have a huge impact on employee engagement, leading to low productivity and high staff turnover. On the flip side, effectively preventing burnout can improve employee retention and help to attract future talent. This article outlines 13 ways Life Science employers can reduce employee burnout; from writing a descriptive and well-thought-out job description to redesigning the physical workplace.
With the Life Science industry being put under more pressure than ever in recent years, employee burnout is on the rise. The World Health Organization (WHO) define burnout as “a syndrome conceptualised as resulting from chronic workplace stress that has not been successfully managed.” According to WHO, symptoms include: Energy depletion and exhaustion Mental distance from…

The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions.
Benefits of forced degradation test The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions. Provide support for drug safety. When toxicologically relevant impurities are not readily available, toxicological evaluation of samples degraded to a certain extent can provide a supportive basis for drug safety and impurity limit determination. It is helpful for metabolite research. Some degradation products are also metabolites, and the m…

Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those non-coding fragments in human genes are also vital and not the so-called "transcriptional noise".
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferatio…

Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present the application of bioinformatics in the study and fight against cancer and infectious diseases.
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ…

With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive.
With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive.   The relationship between enzymes and certain diseases The diseases caused by the lack of enzymes in the human body are mostly congenital or hereditary. For example, albinism is caused by the lack of tyrosine hydroxylase, and patients with broad bean disease or sensitivity to primaqui…

The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes.
The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes.   The development of restriction endonucleases In the early 1960s, Werner Arber came up with the idea that there was an enzyme that would cut the DNA of a virus, thereby limiting the virus' proliferation.…

Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. Since mitochondria play an important role in the maintenance of homeostasis, their abnormal function is associated with many human diseases, such as neurodegenerative diseases, cancer, heart disease and diabetes.
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed…

Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test item.
Principle of Luminex Multiplex Assay Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test item. The fluorescent coding microsphe…

PEG-linkers are particularly attractive as a linker for Antibody–drug conjugates (ADCs). Water solubility, lack of toxicity; low immunogenicity and well-defined chain lengths and molecular weights are specific characteristics of PEG moieties relevant to pharmaceutical applications
As the field of antibody-drug conjugation chemistry has advanced, the use of linkers to impart "drugability" has also been growing. Biopharma PEG  leapts at the opportunity to develp various high purity PEG derivatives used as ADC linkers. Antibody–drug conjugates (ADCs) or immunoconjugates have shown to offer the unique benefits of a targeted therapeutic strategy combined with the best features of both therapeutic monoclonal antibodies (mAb) and potent small-molecule cytotoxic drugs through a linke…

In this article, we’ve rounded up the best Pharmaceutical and Life Science workplaces for well-being in the UK, based on the official rankings given by The Great Place to Work Institute in 2022.
In this article, we’ve rounded up the best Pharmaceutical and Life Science workplaces for well-being in the UK, based on the official rankings given by The Great Place to Work Institute in 2022… Medium Workplaces (51-250 Employees) Alnylam (Pharmaceuticals) Anlylam is leading the translation of RNA interface into new innovative medicines with the aim to transform the lives of people affected by rare and prevalent diseases with unmet needs. Ranking 51st in the Medium Workplaces category, the company offers employee benefits including medical, dental and vision insurance as well as emotional health be…

In the UK, the number of job vacancies has now exceeded the number of people unemployed for the first time, and similar trends are being seen across the globe. Making your job adverts stand out against so many others is becoming tougher than ever, yet it’s not an impossible challenge. In this article, we look at 7 ways to improve your job advert SEO, helping you to continue to attract the best talent in the Life Science industry.
If you’re currently hiring within the Life Sciences sector and are struggling to get your job adverts seen, then it might be time to review your Search Engine Optimisation (SEO). In the UK, the number of job vacancies has now exceeded the number of people unemployed for the first time, and similar trends are being seen across the globe. Making your job adverts stan…

The pharmaceutical and biopharmaceutical industries have been seeing a trend towards single-use technologies. However, this new approach and the introduction and advance of personalized therapies are currently leading to massive supply-chain delays in terms of single-use consumables. Therefore, new solutions have to be found and companies have to think strategically and change up processes as soon as possible.
As there is an upward trend to single-use technologies, strategic thinking and the courage to change up processes are called for in the pharma industry. The pharmaceutical and biopharmaceutical industries are seeing a major shift to disposable technologies. However, this shift and the introduction and advance of personalized and allogeneic therapies are currently leading to massive su…

Centred Solutions Sales and Marketing Director, Louise Laban, gives her view on the current consultation into hub and spoke dispensing and questions some of the information included in the associated impact assessment.
“The second long awaited consultation on proposed changes to UK legislation to allow all community pharmacies to access hub and spoke dispensing is finally underway. Six years on from the original consultation, there remains speculation within the pharmacy market that the proposals may allow larger chains with automated hubs to charge smaller chains and independent pharmacies for “prescription assembly services” leading to an erosion of profits that cannot be recouped by any amount of patient facing services. Unfortunately the impact assessment into hub and spoke published by…

Historically, the way patients have been treated for diseases has been centred around our understanding of a dominant version of a disease as it occurs in the average human. The ailment is identified, a treatment path is offered, and drugs are prescribed. The effectiveness of this treatment, however, can vary due to a range of factors.
Historically, the way patients have been treated for diseases has been centred around our understanding of a dominant version of a disease as it occurs in the average human. The ailment is identified, a treatment path is offered, and drugs are prescribed. The effectiveness of this treatment, however, can vary due to a range of factors. The patient might have a particular variation of a disease, or a conflicting condition, or their biological makeup means cert…

A successful hit identification campaign relies on the use of a high-quality, diverse library of potential compounds to be screened, but also on capitalizing on other complementary techniques, such as structure-based virtual screening (SBVS) and fragment-based screening.
The major preclinical phases of peptide drug discovery encompass initial target identification and validation, hit identification, high throughput screening, lead optimization, etc. Among them, hit identification is one of the most critical steps in identifying peptides that can interact with well-validated targets.   Hit identification (HI) follows the process of target validation, in which the compound screening assays are developed. The main goal of the HI process is to apply the most suitable hit finding approaches…

Our work demands us to be mentally alert. There’s not much cruise control or autopilot in our industry. As a result, we need to be even more aware of self care and balance, to avoid burnout
Our work demands us to be mentally alert. There’s not much cruise control or autopilot in our industry. As a result, we need to be even more aware of self care and balance, to avoid burnout That's why it's important to cultivate a positive and flexible way of looking at things, and to keep your energy levels high. As a bonus, when you’re happy and focused, you can deliver more value and support to those around you In this article, we’ll share tips and ideas on how to build and maintain personal resilience. And how to develop the necessary behaviour to become an attractive candidate when seeking new roles…

“Australian companies with real ambition, realizing they could access the best talent anywhere on the globe, became very open to hiring executives in the US and Europe who could work remotely” Michael Huberts, Executive Director at Coulter Partners, provides an Australian perspective on Executive Search and Leadership Consulting in the Life Sciences, Health and Tech sectors. He explores the impact of the global Covid pandemic, the challenges of shrinking talent pools, government initiatives and investments, leadership diversity, digital health, and current trends.
“Australian companies with real ambition, realizing they could access the best talent anywhere on the globe, became very open to hiring executives in the US and Europe who could work remotely” Michael Huberts, Executive Dire…

Without a firm grip on data quality, life sciences companies will continue to be caught out by audits, missed registrations, or project disruption. As data becomes more important than documents, Amplexor’s Agnes Cwienczek provides practical starting points towards ensuring data quality, integrity, currency and completeness.
A comprehensive, approved master data source is increasingly vital to support a whole range of activities, whether submission and compliance related, or supporting internal analytics and management reporting. Without complete confidence in a defined quality, integrity, currency and completeness of data, however, there are two main risks to the business functions. One is that they will fall foul of the authorities, providing inaccurate or out-of-date information, and as a…

Clinical research is a process of testing the safety and efficacy of drugs and other medical products. It is done by qualified professionals who are responsible for the design, conduct, analysis, and reporting of clinical trials.
What is Clinical Research? Clinical research is a process of testing the safety and efficacy of drugs and other medical products. It is done by qualified professionals who are responsible for the design, conduct, analysis, and reporting of clinical trials. Clinical research is a process that ensures the safety and efficacy of drugs and other medical products. Clinical research professionals are responsible for designing, conducting, analyzing, and reporting clinical trials that test these products. Pharmacovigilance Courses in Pune. What is the Scope of Clinical Re…