Articles

Medical CRM can help healthcare organizations better understand and serve their patients, reconnect with ‘lost’ patients, and attract new ones. Additionally, it can automate some of the important workflows, provide an easy and secure data exchange environment, and relieve staff from routine tasks, giving them more time to care for patients and grow professionally. High-quality healthcare CRM is a complex system requiring time and budget to be implemented and extra time on organizing user training sessions. However, given the benefits mentioned in this article, it is worth the investment. To take the most advantage of this investment, it should be approached with a clear vision of the organization’s needs and goals.
Healthcare organizations are dedicated to providing excellent care for th…

For large- or small-scale fermentation, process optimization in some critical steps plays an important role in improving efficiency because it can directly affect the formation, concentration, and yield of a particular fermentation end product, thus affecting the overall economics.
However, the improvement of fermentation process is frequently associated with a lot of challenges: it's expensive, laborious, open-ended, and time-consuming. There are many aspects requiring attention from CDMOs to obtain better outcomes. The article below explores different well-known elements that are vital in the whole fermentation process.   Upstream Process Optimization Upstream process optimization is used for microbial fermentation to enhance the strains' manufacturing efficiency and capac…

It is an efficient way to regulate molecular function by applying specific chemical modifications on biological molecules. This article highlights the current heated pseudoUridine modification in RNA, which suggests new possibilities for novel drug or vaccine discovery.
An Introduction to PseudoUridines PseudoUridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions and affects gene expression. PseudoUridine modification is also named "fifth base" since it is the earliest and most abundant RNA modification among the 170+ types of known RNA modifications.   Messenger RNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms responsible for selective and regulated…

Many research institutes and pharmaceutical companies are now actively engaged in COVID-19 research and treatment development, which makes some supportive reagents, services, and consultations in high demand around the world.
This article briefly summarizes several relatively important solutions that can greatly facilitate COVID-19 research.   COVID-19 mRNA Vaccine Development Support The global outbreak of COVID-19 in early 2020 caused a large amount of investment and research attention to developing preventive vaccines. Among the massive achievements made by using published genomes, mRNA vaccines against SARS-CoV-2 stand out because of their better performance in efficiency and cost-effectiveness. Currently, mRNA vaccine is publicly deemed as a very useful strategy in anti-…

Phytochemicals are natural compounds that have only been discovered so far and are natural food pigments. The human body is unable to produce them and must obtain them from food. Soy isoflavones in soybeans, lycopene in tomatoes, catechins in green tea, carotenoids in carrots, zeaxanthin, polyphenols, etc., are all phytochemicals.
What Are Phytochemicals? Phytochemicals are natural compounds that have only been discovered so far and are natural food pigments. The human body is unable to produce them and must obtain them from food. Soy isoflavones in soybeans, lycopene in tomatoes, catechins in green tea, carotenoids in carrots, zeaxanthin, polyphenols, etc., are all phytochemicals.   Classification and Functions of Common Phytochemicals Flavonoids Species: Quercetin, brassin, catechin…

The functioning of biological systems is inextricably linked to protein-protein interactions, and important biological processes such as DNA synthesis, gene transcriptional activation, protein translation, modification and localization, and information transfer all involve the role of protein complexes.
Introduction to protein interactions The functioning of biological systems is inextricably linked to protein-protein interactions, and important biological processes such as DNA synthesis, gene transcriptional activation, protein translation, modification and localization, and information transfer all involve the role of protein complexes. Therefore, it is particularly important to discover and verify protein-nucleic acid and protein-protein interactions in living organisms. Various techniqu…

Ceramides are composed of sphingosine analogs and long-chain fatty acids bound by amide bonds, and are the most important of the sphingolipid compounds. Ceramide is synthesized and secreted by lamellar vesicles, which together with cholesterol (25%) and free fatty acids (15%) constitute the intercellular lipids (ceramide 50%) involved in maintaining the skin barrier function. It also has various physiological and pharmacological functions, such as regulation of cellular immunity, delaying aging, and antitumor.
Ceramides are composed of sphingosine analogs and long-chain fatty acids bound by amide bonds, and are the most important of the sphingolipid compounds. Ceramide is synthesized and secreted by lamellar vesicles, which together with cholesterol (25%) and free fatty acids (15%) constitu…

Under ‘normal’ circumstances, citizens already hope to deal with the public sector in the same seamless and convenient way that they shop online for groceries. However, during large-scale crises – like, but not limited to the ongoing pandemic, rather than downsizing staff within public services, they are having to work harder than ever before.
In current times, businesses and citizens are seeking more reassurance and proactive support from the public sector than ever before, as they weather the remaining storm of COVID-19. In turn, those working in the public are dealing with a long list of challenges every single day to meet new needs and requirements.   Under ‘normal’ circumstances, citizens already hope to deal with the public sector in the same seamless and convenient way that the…

Medicines are becoming ever more complex in response to growth in personalised treatments and the development of a wide range of therapeutics to address less common conditions or rare diseases
by Kelly Doering, Sr Director, Industry Marketing, Pharma, AspenTech Medicines are becoming ever more complex in response to growth in personalised treatments and the development of a wide range of therapeutics to address less common conditions or rare diseases. Examples of the latter include small molecules linked to large, perhaps conjugated to a chemotoxic agent for targeted cancer treatment; peptides linked to peptides; oligos linked to molecules that allow for better cell permeability; and lipid-encapsulated molecules that prevent degradation. But it is the market for more personalised medication…

The pharmaceutical and biopharmaceutical industries have been seeing a trend towards single-use technologies. However, this new approach and the introduction and advance of personalized therapies are currently leading to massive supply-chain delays in terms of single-use consumables. Therefore, new solutions have to be found and companies have to think strategically and change up processes as soon as possible.
As there is an upward trend to single-use technologies, strategic thinking and the courage to change up processes are called for in the pharma industry. The pharmaceutical and biopharmaceutical industries are seeing a major shift to disposable technologies. However, this shift and the introduction and advance of personalized and allogeneic therapies are currently leading to massive su…

Stable isotope-labeled peptides have also been widely used in (NMR) spectroscopy and mass spectrometry (MS) as well as reference materials for pharmacokinetic analysis and metabolite identification.
Peptides are organic compounds formed by the dehydration of amino acids and intermediate products of protein hydrolysis. Peptides have strong biological activity, which can regulate the functional activities of cells in living organisms, and play a variety of roles in medicine, cosmetics, food, and other fields. With the more and more extensive and in-depth applications of peptides, the demand for labeled and modified peptides is growing, and the quality requirement is also higher and higher. To obtain peptides with higher biological activity, fluorescent modification, isotop…

ADCs demonstrated great potential for the treatment of cancers, and simultaneously require unique supporting infrastructure to meet biopharmaceutical industry standards for safe, effective, and reliable manufacturing.
Antibody-drug conjugates (ADCs) are formed by covalent biochemical conjugation of monoclonal antibodies (mAb) with payload drugs through small molecular linkers. They are regarded as an emerging class of drugs designed for high-specificity targeting and destruction of cancer cells, since the specificity of mAb to tumor cells allows small-molecule drugs to target tumor tissues, effectively reducing the high toxicity of traditional small-molecule drugs and improving overall treatment efficiency.   ADC manufacturing consists of multiple steps that can be divided in…

The Covid pandemic has elevated the diagnostics industry to new heights of relevance and given it a place in the popular consciousness not previously seen.
The subsequent rise in global fuel prices and the economic impact of the war in Ukraine have also focused the minds of medical technology company bosses and health budget planners on the need to do more with fewer resources. All of these developments, coupled with greater use of artificial intelligence (AI) in medicine, means that technology has never been more important to the health of populations. This is particularly true of in vitro diagnostics – with the pandemic accelerating investment in infectious disease diagnoses to unprecedented levels – and with activity now spinning out to other areas. A market research study published this…

Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. Microbiomes from depressed patients were transplanted into rats, which developed similar mental health problems.
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs.…

Single-nucleotide polymorphisms (SNPs) are a kind of DNA polymorphisms caused by single-nucleotide variants in both coding and non-coding regions, which are the most common and smallest variants. There are more than 3 million SNPs in the human genome with an average of 1 in 500-1000 base pairs. SNP microarrays are capable of detecting a large number of subtle DNA alterations and/or abnormal alterations related to chromosome copy number (aneuploidy) or chromosome structural rearrangements. In human species, SNP microarrays can simultaneously analyze all 23 chromosome pairs and can also be used to identify mutations in individual genes. In addition, SNPs can be used for genotyping, i.e., determining the proportion of each allelic variant combination at each nucleotide position.
Single-nucleot…

The development of DNA sequencing technology has made it possible for human beings to explore the mysteries of themselves and other beings, while the advent of the genomics era has put higher demands on sequencing technologies. Scientific research has now entered the era of high throughput, moving from single, localized genes or fragments to the study of the entire genome, covering basic science, disease diagnosis and treatment, agriculture and the environment.
The development of DNA sequencing technology has made it possible for human beings to explore the mysteries of themselves and other beings, while the advent of the genomics era has put higher demands on sequencing technologies. Scientific research has now entered the era of high throughput, moving from single, localized genes or frag…

The epigenome is composed of chemical markers and proteins that can attach to DNA and direct the function of gene regulatory elements, controlling the production of proteins in specific cells, among other roles. Common epigenomic modifications include methylation of the nucleotide cytosine and histones or acetylation and phosphorylation of histones. All of these modifications do not change the genome sequence, but they do change the way the cell uses the same set of genetic codes, thus altering phenotypes and metabolic activities. The epigenome is also inheritable.
The epigenome is composed of chemical markers and proteins that can attach to DNA and direct the function of gene regulatory elements, controlling the production of proteins in specific cells, among other roles. Common epigenomic…

Automation Testing Training helps demonstrate how helpful automation testing is to developers. Firstly, it doesn’t need any type of human intervention.
Advantages of Automation Testing tools learnt in Automation Testing Training Automation Testing Training helps demonstrate how helpful automation testing is to developers. Firstly, it doesn’t need any type of human intervention. Secondly, there is no restriction on how many times on the number of automation test. Thirdly, it minimizes the cost of testing. Finally, Automation testing can be run at any time of the day. Therefore, Automation Testing training helps students discover different tools. Challenges outlined during Automation Testing Training. There are different challenges that are outlined during the duration of Automation Testing…

Amylase is a general term for enzymes that hydrolyze starch and glycogen with the specificity of enzyme preparation. Its main mechanism of action is to hydrolyze starch into maltose, glucose, dextrin, etc. To understand amylase, we must first understand starch, which is a storage polysaccharide stored in cells as starch granules during plant growth, and exists in seeds and tubers. Starch is not a simple molecule, but a mixture of two different types of starch, divided into two categories: amylose and amylopectin.
Amylase is a general term for enzymes that hydrolyze starch and glycogen with the specificity of enzyme preparation. Its main mechanism of action is to hydrolyze starch into maltose, glucose, dextrin, etc. To understand amylase, we must first understand starch, which is a storage p…

CRISPR/Cas9 gene editing technology has been widely used in many fields since its inception. Gene therapy developed using this technology has huge prospects in the medical and health fields. CRISPR/Cas9 technology enables gene-editing of the genome at specified sites, but a common worry about the technology is that gene-editing occurs where it shouldn't.
CRISPR/Cas9 gene editing technology has been widely used in many fields since its inception. Gene therapy developed using this technology has huge prospects in the medical and health fields. CRISPR/Cas9 technology enables gene-editing of the genome at specified sites, but a common worry about the technology is that gene-editing occurs where it shouldn't. In recent years, researchers at the University of Bath and Cardiff University in the UK…