Articles
Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules.
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, and anti-inflammatory agents. Liposomal formulations have unique advantages in both safety and efficacy, so they are one of the most rapidly developing formulations in recent years. In the past 30 years, research in the field of liposomes has made great progress. Various types…
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, and anti-inflammatory agents. Liposomal formulations have unique advantages in both safety and efficacy, so they are one of the most rapidly developing formulations in recent years. In the past 30 years, research in the field of liposomes has made great progress. Various types…
The healthcare sector is an enormous conceptualization that includes businesses that provide medical services like hospitals, nursing homes, private clinical, fabricated medical equipment or drugs like pharmaceuticals, healthcare technology, medical insurance, and other medical facilities that offer services to patients. Any company includes products or services belonging to the healthcare sector.
The healthcare sector is an enormous conceptualization that includes businesses that provide medical services like hospitals, nursing homes, private clinical, fabricated medical equipment or drugs like pharmaceuticals, healthcare technology, medical insurance, and other medical facilities that offer services to patients. Any company includes products or services belonging to the healthcare sector.…
The healthcare sector is an enormous conceptualization that includes businesses that provide medical services like hospitals, nursing homes, private clinical, fabricated medical equipment or drugs like pharmaceuticals, healthcare technology, medical insurance, and other medical facilities that offer services to patients. Any company includes products or services belonging to the healthcare sector.…
01-Sep-2022
Engineered bacteria can be used as anticancer agents, in which suitable bacterial strains are engineered to colonize hypoxic tumor environments and provide therapeutic payloads.
Engineered bacteria can be used as anticancer agents, in which suitable bacterial strains are engineered to colonize hypoxic tumor environments and provide therapeutic payloads. The hypoxic microenvironment changes tumor cell metabolism and leads to cell quiescence, which contributes to tumor cell resistance to therapy. Live bacteria can inherently colonize areas of hypoxic tumors. In tumor-bearing mice, the intravenously injected bacteria were initially delivered nonpreferentially to healthy and tumor tissues. Over time, the nontumor tissues and circulating bacteria were rapidly cleared, whereas the tumor bacteria…
Engineered bacteria can be used as anticancer agents, in which suitable bacterial strains are engineered to colonize hypoxic tumor environments and provide therapeutic payloads. The hypoxic microenvironment changes tumor cell metabolism and leads to cell quiescence, which contributes to tumor cell resistance to therapy. Live bacteria can inherently colonize areas of hypoxic tumors. In tumor-bearing mice, the intravenously injected bacteria were initially delivered nonpreferentially to healthy and tumor tissues. Over time, the nontumor tissues and circulating bacteria were rapidly cleared, whereas the tumor bacteria…
Due to the wide range of oligonucleotide drug indications, including tumors, rare diseases (amyotrophic lateral sclerosis, Duchenne muscular dystrophy, spinal muscular atrophy), viral diseases, kidney diseases, cardiovascular diseases, inflammatory diseases, and metabolic diseases (diabetes) are expected to bring about the small molecular drugs, antibody drugs after a wave of new drug research and development.
Introduction of oligonucleotide drugs Oligonucleotides are a class of nucleic acid molecules consisting of dozens of nucleotides with short sequences. They mainly inhibit the expression of target proteins through gene silencing so as to achieve the purpose of treating diseases. The world's first antisense nucleic acid drug was approved in 1998, which started the journey of oligonucleo…
Introduction of oligonucleotide drugs Oligonucleotides are a class of nucleic acid molecules consisting of dozens of nucleotides with short sequences. They mainly inhibit the expression of target proteins through gene silencing so as to achieve the purpose of treating diseases. The world's first antisense nucleic acid drug was approved in 1998, which started the journey of oligonucleo…
01-Sep-2022
A variety of newly developed peptide-based drugs are expected to become a promising new class of anti-tumor therapeutic drugs. This blog will give a brief introduction to anti-tumor drugs based on peptide form.
Peptide-based drug design has attracted much interest with the rapid growth of bioinformatics knowledge related to peptides and proteins. In the past, peptide-based drugs were not widely used due to some limitations such as low selectivity and rapid degradation of peptides in biological systems. Excitingly, novel peptide-based therapies emerged in recent years, showing excellent anti-tumor efficacy. A variety of newly developed peptide-based drugs are expected to become a promising new class of anti-tumor therapeutic drugs. This blog will give…
Peptide-based drug design has attracted much interest with the rapid growth of bioinformatics knowledge related to peptides and proteins. In the past, peptide-based drugs were not widely used due to some limitations such as low selectivity and rapid degradation of peptides in biological systems. Excitingly, novel peptide-based therapies emerged in recent years, showing excellent anti-tumor efficacy. A variety of newly developed peptide-based drugs are expected to become a promising new class of anti-tumor therapeutic drugs. This blog will give…
01-Sep-2022
CPPs are believed to matter a lot in the treatment of animal and human diseases as more interdisciplinary research goes deeper and its potential effectiveness and specificity continue to be explored.
Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nano-size particles to small chemical compounds to large fragments of DNA. As a versatile peptide, CPP has been widely used for diagnostic and therapeutic applications. 1. Oligo and siRNA Transport As an important means for targeted therapy of specific genes, oligonucleotides and siRNA can regulate protein activation and post-transcriptional gene expression. Besides, they’re also broadly utilized in the research of signal transmission systems, upstream and downstrea…
Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nano-size particles to small chemical compounds to large fragments of DNA. As a versatile peptide, CPP has been widely used for diagnostic and therapeutic applications. 1. Oligo and siRNA Transport As an important means for targeted therapy of specific genes, oligonucleotides and siRNA can regulate protein activation and post-transcriptional gene expression. Besides, they’re also broadly utilized in the research of signal transmission systems, upstream and downstrea…
Although entry level roles don’t require you to have the full set of skills and experiences needed to do a particular job, having a very limited skillset can make it harder to stand out against your peers. To get your first role in the pharmaceutical industry, proactively developing your transferable skills whilst building valuable professional relationships can really help to strengthen your applications and build your knowledge around working in the industry.
Although entry level roles don’t require you to have the full set of skills and experiences needed to do a particular job, having a very limited skillset can make it harder to stand out against your peers. To get your first role in the pharmaceutical industry, proactively developing your transferable skills whilst building valuable p…
Although entry level roles don’t require you to have the full set of skills and experiences needed to do a particular job, having a very limited skillset can make it harder to stand out against your peers. To get your first role in the pharmaceutical industry, proactively developing your transferable skills whilst building valuable p…
In recent years, governments worldwide have emphasised the need to shift towards a circular economy for packaging, with a particular focus on phasing out single-use, virgin, and unrecyclable plastics and exploring options for reusable products and refillable packaging. Many brands have also established ambitious commitments to make their packaging more sustainable by 2025. More than 500 organisations have signed up to the Ellen MacArthur Foundation’s New Plastics Economy Global Commitment.
In recent years, governments worldwide have emphasised the need to shift towards a circular economy for packaging, with a particular focus on phasing out single-use, virgin, and unrecyclable plastics and exploring options for reusable products and refillable packaging. Many brands have also established a…
In recent years, governments worldwide have emphasised the need to shift towards a circular economy for packaging, with a particular focus on phasing out single-use, virgin, and unrecyclable plastics and exploring options for reusable products and refillable packaging. Many brands have also established a…
26-Aug-2022
Having a personal brand is key when it comes to standing out against other candidates and making your name one that recruiters will remember. When searching for your next pharma job, developing your personal brand will help recruiters to understand who you are, what you stand for, the value you can bring to their organisation, and what you have that other candidates don’t.
Having a personal brand is key when it comes to standing out against other candidates and making your name one that recruiters will remember. When searching for your next pharma job, developing your personal brand will help recruiters to understand who you are, what you stand for, the value you can bring to their organisation, and what you have that other candidates don’t. In today’s highly competitive job market, having…
Having a personal brand is key when it comes to standing out against other candidates and making your name one that recruiters will remember. When searching for your next pharma job, developing your personal brand will help recruiters to understand who you are, what you stand for, the value you can bring to their organisation, and what you have that other candidates don’t. In today’s highly competitive job market, having…
Scientists in Sweden from Linköping University have successfully developed implantable corneas from pig skin for 14 previously blind patients. From sites in Iran and India, a study was performed on 20 patients who got an implant for restoring their corneal thickness and curvature to a normal level. The visual outcome was perfect as a human-donated cornea was used.
Scientists in Sweden from Linköping University have successfully developed implantable corneas from pig skin for 14 previously blind patients. From sites in Iran and India, a study was performed on 20 patients who got an implant for restoring their corneal thickness and curvature to a normal level. The visual outcome was perfect as a human-donated cornea was used. Fourteen patients entered the pilot study blind, and after two ye…
Scientists in Sweden from Linköping University have successfully developed implantable corneas from pig skin for 14 previously blind patients. From sites in Iran and India, a study was performed on 20 patients who got an implant for restoring their corneal thickness and curvature to a normal level. The visual outcome was perfect as a human-donated cornea was used. Fourteen patients entered the pilot study blind, and after two ye…
25-Aug-2022
Long Covid is a range of new, returning, or ongoing symptoms after the infection of Covid-19, also known as post-acute sequelae of SARs CoV-2 infection(PASC), technically by name. Its symptoms vary, and it has no test for its diagnosis. After a month of infection, the symptoms appear as fatigue, difficulty breathing, cough, brain fog, diarrhoea, pains in the joints, muscles, stomach, and many more.
Long Covid is a range of new, returning, or ongoing symptoms after the infection of Covid-19, also known as post-acute sequelae of SARs CoV-2 infection(PASC), technically by name. Its symptoms vary, and it has no test for its diagnosis. After a month of infection, the symptoms appear as fatigue, difficulty breathing, cough, brain fog, diarrhoea, pains in the joints, muscles, stomach, and many mor…
Long Covid is a range of new, returning, or ongoing symptoms after the infection of Covid-19, also known as post-acute sequelae of SARs CoV-2 infection(PASC), technically by name. Its symptoms vary, and it has no test for its diagnosis. After a month of infection, the symptoms appear as fatigue, difficulty breathing, cough, brain fog, diarrhoea, pains in the joints, muscles, stomach, and many mor…
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene regulation.
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene regulat…
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene regulat…
Since the first discovery of 16s rRNA sequences in environmental samples in 1990 and their value in microbial community research, we have entered the era of microbial community research in full swing. Today, community research has entered the high throughput sequencing era, and the mainstream of current research is at the intersection of next-generation amplicon sequencing and long-read amplicon sequencing.
Since the first discovery of 16s rRNA sequences in environmental samples in 1990 and their value in microbial community research, we have entered the era of microbial community research in full swing. Today, community research has entered the high throughput sequencing era, and the mainstream of current research is at the intersection of next-generation amplicon sequencing and long-read…
Since the first discovery of 16s rRNA sequences in environmental samples in 1990 and their value in microbial community research, we have entered the era of microbial community research in full swing. Today, community research has entered the high throughput sequencing era, and the mainstream of current research is at the intersection of next-generation amplicon sequencing and long-read…
26-Aug-2022
HLA, human leukocyte surface antigen, a series of tightly interlocking motifs on the short arm of human chromosome 6, is the central basis for the immune system to recognize and differentiate between allogeneic substances.
HLA, human leukocyte surface antigen, a series of tightly interlocking motifs on the short arm of human chromosome 6, is the central basis for the immune system to recognize and differentiate between allogeneic substances. It is highly polymorphic and corresponds to a complex acquired immune system. It is importantly associated with a variety of autoimmune diseases, tumors, and infectious diseases. Also, HLA plays a crucial role in transplants such as organ and bone marrow transplant and is associated with serious adverse reactions to many drugs. Therefore, HLA typing is…
HLA, human leukocyte surface antigen, a series of tightly interlocking motifs on the short arm of human chromosome 6, is the central basis for the immune system to recognize and differentiate between allogeneic substances. It is highly polymorphic and corresponds to a complex acquired immune system. It is importantly associated with a variety of autoimmune diseases, tumors, and infectious diseases. Also, HLA plays a crucial role in transplants such as organ and bone marrow transplant and is associated with serious adverse reactions to many drugs. Therefore, HLA typing is…
The cell is the basic unit of life. Most current studies on the human genome, cancer or other fields are still conducted from the population level, and the results are often the mean value of gene expression in cell populations or only represent information on the vital activities of numerically dominant cells, while failing to accurately reflect much of the information on cellular heterogeneity and ignoring the variability of gene expression regulation between cells.
The cell is the basic unit of life. Most current studies on the human genome, cancer or other fields are still conducted from the population level, and the results are often the mean value of gene expression in cell populations or only represent information on the vital activities of numerically dominant cells, while failing t…
The cell is the basic unit of life. Most current studies on the human genome, cancer or other fields are still conducted from the population level, and the results are often the mean value of gene expression in cell populations or only represent information on the vital activities of numerically dominant cells, while failing t…
Product-level serialisation has historically been associated with compliance mandates within highly regulated industries such as pharmaceuticals, medical devices, and tobacco. Its central premise was to prevent counterfeit goods from entering these markets. However, as organisations within these sectors have realised, having full traceability within the supply chain offers benefits beyond compliance alone, providing opportunities for greater visibility, data exchange, and more.
Product-level serialisation has historically been associated with compliance mandates within highly regulated industries such as pharmaceuticals, medical devices, and tobacco. Its central premise was to prevent counterfeit goods from entering these markets. However, as organisations within these sectors have realise…
Product-level serialisation has historically been associated with compliance mandates within highly regulated industries such as pharmaceuticals, medical devices, and tobacco. Its central premise was to prevent counterfeit goods from entering these markets. However, as organisations within these sectors have realise…
To further understand what is important to jobseekers using PharmiWeb.Jobs, we recently ran a LinkedIn poll asking the question “What is the most important factor when you’re looking for a new job?” Our poll received 374 responses from jobseekers across the United Kingdom, United States, Australia and Europe, and produced the following results.
As a Life Science recruiter or hiring manager, knowing exactly what your target audience of jobseekers are looking for in their next role is essential in order to attract and engage top talent. To further understand what is important to jobseekers using PharmiWeb.Jobs, we recently ran a LinkedIn poll asking the question “What is the most important factor when you’re looking for a new job?” Our poll received 374 responses from jobseekers across the Un…
As a Life Science recruiter or hiring manager, knowing exactly what your target audience of jobseekers are looking for in their next role is essential in order to attract and engage top talent. To further understand what is important to jobseekers using PharmiWeb.Jobs, we recently ran a LinkedIn poll asking the question “What is the most important factor when you’re looking for a new job?” Our poll received 374 responses from jobseekers across the Un…
When preparing for your next pharma job interview, you’ll need to be prepared to answer some of the most commonly asked – and the hardest – job interview questions. You only have a short amount of time to leave a strong impression on your interviewer, so make the most of this by doing your research and arming yourself with structured, well thought out answers that will set you apart from your peers.
When preparing for your next pharma job interview, you’ll need to be prepared to answer some of the most commonly asked – and the hardest – job interview questions. You only have a short amount of time to leave a strong impression on your interviewer, so make the most of this by doing your research and arming yourself with structured, well thought out answers that will set you apart from your pe…
When preparing for your next pharma job interview, you’ll need to be prepared to answer some of the most commonly asked – and the hardest – job interview questions. You only have a short amount of time to leave a strong impression on your interviewer, so make the most of this by doing your research and arming yourself with structured, well thought out answers that will set you apart from your pe…
27-Sep-2022
As well as being against the law in many countries across the globe, discrimination – whether intentional or not – can seriously damage your reputation as an employer, making it even more challenging to attract and retain top talent. Following on from our previous articles on how to improve your Life Science job adverts and how to improve your job advert SEO, this article outlines how to avoid different types of discrimination in your job adverts, although it does not act as legal advice.
As a Life Science employer/recruiter, you must take steps to avoid discrimination across your entire recruitment journey, including in how you present your job adverts. As well as being against the law in many countries across the globe, discrimination – whether intentional or not – can seriously damage y…
As a Life Science employer/recruiter, you must take steps to avoid discrimination across your entire recruitment journey, including in how you present your job adverts. As well as being against the law in many countries across the globe, discrimination – whether intentional or not – can seriously damage y…
04-Aug-2022
It is no secret that the COVID-19 pandemic has made burnout worse in the healthcare industry, but it can't take all the blame because, before its existence, clinical burnout already existed. Many factors can contribute to the shortage of talented-health care, ranging from an ageing workload to high demand for care.
It is no secret that the COVID-19 pandemic has made burnout worse in the healthcare industry, but it can't take all the blame because, before its existence, clinical burnout already existed. Many factors can contribute to the shortage of talented-health care, ranging from an ageing workload to high demand for care. However, health care organisations and hospitals will have difficulties finding and retaining the number of staff they need. It will cause an increased workload for th…
It is no secret that the COVID-19 pandemic has made burnout worse in the healthcare industry, but it can't take all the blame because, before its existence, clinical burnout already existed. Many factors can contribute to the shortage of talented-health care, ranging from an ageing workload to high demand for care. However, health care organisations and hospitals will have difficulties finding and retaining the number of staff they need. It will cause an increased workload for th…
