Articles

Leukemia cell lines are important and widely used research tools. Their usefulness is mainly connected with their ability to provide an indefinite source of biological material for experimental purposes. Due to their high relevance for human disease, easy manipulation, and relative low costs, leukemia cell lines continue to represent vital in vitro model systems for a large range of ongoing investigations, especially basic leukemia research and drug discovery.
Leukemia cell lines are important and widely used research tools. Their usefulness is mainly connected with their ability to provide an indefinite source of biological material for experimental purposes. Due to their high relevance for human disease, easy manipulation, and relative low costs, leukemia cell lines continu…

The SH-SY5Y cell line is in the widespread use in experimental neurological studies, including the analysis of neuronal differentiation, metabolism, functions related to neurodegenerative and neuroadaptive processes, neurotoxicity, and neuroprotection.
Background SH-SY5Y cells, the subline of the parental line SK-N-SH cells, are originally established from a bone marrow biopsy of a neuroblastoma patient with sympathetic adrenergic ganglial origin. SK-N-SH were subcloned three times: first to SH-SY, and then to SH-SY5, finally to SH-SY5Y. SH-SY5Y were deposited to the ATCC® in 1970 by June L. Biedler. Once the primary mammalian neurons derived from embryonic central nervous system tissue terminally differentiate into mature neurons, the cells can be no longer propagated. While…

When attending your next pharma job interview, remember that interviewers aren’t only assessing you during the interview, but also throughout the entire process. How you act after your job interview – regardless of whether it’s your first, second or final round – can have a big impact on the impression you make on interviewers. In this article, we outline 11 things you can do after your next pharma job interview to prove your strength as a candidate.
When attending your next pharma job interview, remember that interviewers aren’t only assessing you during the interview, but also throughout the entire process. How you act after your job interview – regardless of whether it’s your first, second or final round – can have a big impact on the impression you make on interviewers. In this article,…

According to LinkedIn, around 60% of job seekers use job boards to search for new roles, making it one of the biggest channels for job hunting. Although job boards provide a great opportunity for you to push your roles to candidates outside of your organisation’s network and to engage large volumes of candidates across multiple platforms, larger boards aren’t always the best way to attract high-quality candidates. This is where niche job boards come in…
According to LinkedIn, around 60% of job seekers use job boards to search for new roles, making it one of the biggest channels for job hunting. Although job boards provide a great opportunity for you to push your roles to candidates outside of your organisation’s network and to engage large volumes of candidates across multiple platforms, la…

13 pharmaceutical events taking place in September 2021, including: Euro-Global Conference on Biotechnology and Bioengineering (September 6th-8th), 4th Edition of Global Conference on Pharmaceutics and Novel Drug Delivery Systems (September 6th-8th), 2nd Operationalize: Decentralized Clinical Trials Summit (September 7th-9th) and more.
13 pharmaceutical events taking place in September 2021: Euro-Global Conference on Biotechnology and Bioengineering (September 6th-8th) The theme of this conference is ‘Addressing Current Challenges in Biotechnology and Bioengineering.’ ECBB 2021 will consist of keynote lectures, oral & poster presentations, workshops, and seminars from experts and young scholars in the field of Biotechnology and Bioengineering. 4th Edition of Global Conference on Pharmac…

Human primary cardiomyocyte-based models are superior to whether artificial cellular models or animal models due to their native physiological and pharmacological properties. Therefore, human primary cardiomyocytes have the potential to become the most clinically relevant model for developing novel cardiac drugs and predicting safety assessment of new drugs.
What are Human Cardiomyocytes? The heart is one of the first organs formed in the embryo, which highlights its crucial function in pumping blood to carry oxygen and nutrients to other tissues of the organism whether during development or in later life. Human primordial heart starts to beat at around 22 days after fertilization. It is the presence of cardiomyocytes that results in the early beating of the heart. Cardiomyocytes,…

Animal primary cells are isolated directly from healthy or diseased tissue via an enzymatic, chemical, or mechanical process. These cells can be taken from the animal’s kidney, liver, skin, or another organ. Once removed from the in vivo environment, these cells are then placed in an artificial (in vitro) environment for propagation.
Animal Primary Cells Animal primary cells are isolated directly from healthy or diseased tissue via an enzymatic, chemical, or mechanical process. These cells can be taken from the animal’s kidney, liver, skin, or another organ. Once removed from the in vivo environment, these cells are then placed in an artificial (in vitro) environment for propagation.   When in an in vitro environment, animal cells must be carefully cultured. This includes ensu…

Stem cells are primitive, undifferentiated cells that can potentially turn into a wide variety of cell types. Liver cells, blood cells, and muscle cells are only a few of the specialized types that have their origin in stem cells. Aside from their ability to differentiate into cells with specific functions, they can also divide or renew themselves indefinitely.
Stem cells are primitive, undifferentiated cells that can potentially turn into a wide variety of cell types. Liver cells, blood cells, and muscle cells are only a few of the specialized types that have their origin in stem cells. Aside from their ability to differentiate into cells with specific functions, they can also divide or renew themselves indefinitely.     Because they can repair and regenerate damaged tissue…

BM-MNCs, the heterogeneous cell mixture, are widely used in cell-based therapy and regenerative medicine, which can promote distinct angiogenic properties, mediate vascular repair, express several cytoprotective growth factors and cytokines and restore pathologically altered genes after ischemic injury. BM-MNCs can be prepared rapidly within a few hours and be collected autologously just prior to administration, which could be advantageous in acute clinical care settings, compared with other cell sources, such as stem cells requiring a period of cell culture before transplantation.
Cell therapy has been identified as an effective method to regenerate damaged tissue. Bone marrow-derived mononuclear cells (BM-MNCs) were first reported on a therapeutic angiogenesis for…

The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value.
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value. However, there are some technical difficulties that hinder the development of children's oral liquid preparations. Poor solubil…

Pharmaceutical organisations in China are increasingly looking abroad for new markets, boosted by their Government’s strong support for businesses that invest overseas. The country is now the world’s second-largest pharma market, behind only the US, and produces around 40 per cent of the world’s active pharmaceutical ingredients.
Pharmaceutical organisations in China are increasingly looking abroad for new markets, boosted by their Government’s strong support for businesses that invest overseas. The country is now the world’s second-largest pharma market, behind only the US, and produces around 40 per cent of the world’s active pharmaceutical ingredients. And with the domestic market also moving from traditional generic medicines to more innovative therapies, Chinese pharma firms are keen t…

As you can’t predict exactly how a job interview will go, it’s important to be fully prepared beforehand to help you stay confident, calm, and collected. Being well prepared will also help you make a great first impression on your interviewer, as it will be very clear to them how much time you’ve put into your preparation, and how much you really care about the role.
As you can’t predict exactly how a job interview will go, it’s important to be fully prepared beforehand to help you stay confident, calm, and collected. Being well prepared will also help you make a great first impression on your interviewer, as it will be very clear to them how much time you’ve put into your preparation, and how much you really care about the role. In this article, we outline 10 things you can do before your…

During the Covid pandemic, digital has transformed everything from patient engagement and recruitment to continuous health monitoring and remote treatment. Kathleen O’Brien of Amplexor Life Sciences reflects on the challenges and considerations.
Process digitalisation is one positive development that has emerged from the Covid pandemic. Reliance on digital channels for conducting consultations, managing treatments and measuring outcomes has allowed many services to continue almost unhindered and the way has been paved for a more digital future. Life sciences companies must now lean into the trend and make the most of the bigger part that remote care and monitoring will play in ongoing treatment models. The FDA’s Digital Health Center of Excellence in the US sets out many of the opportunitie…

With the increasing supply of good quality fresh and cryo-preserved human hepatocytes (such as ABC-TC3646, AcceGen advanced technology), researchers can further apply this in vitro model to advance our knowledge of liver functions, the mechanisms underlying the regulation and drug-induced changes of metabolic enzyme expression and hepatocellular integrity.
Hepatocytes are parenchymal cells that constitute as much as 80% of the total liver volume and mediate a number of vital liver functions, such as the control of lipid and carbohydrate homeostasis, the synthesis of various proteins, the storage of vitamins, the processing of bile, immunological defense, and the biotransformation of endogenous molecules and xenobiotics [1]. Human hepatocytes directly reflect the specific metabolism and func…

A brief introduction to human tumor cell lines. History, benefits and applications of human cancer cell lines.
Tumor cell lines (or cancer cell lines) are derived from the cancerous growths on an organ in a human or animal subject. These cell lines have undergone laboratory modifications that render them immortalized—they are capable of proliferating indefinitely in an in vitro environment. For that reason, tumor cell lines have become invaluable tools in the field of cancer research.   History of Human Cancer Cell Lines In the first half of the 20th century, various experiments demonstrated that animal cell lines could be maintained in an in vitro environment. The first human cell line was established in 1951, from cervical carcinoma cells taken from 30-year-old H…

According to Germany Trade and Invest (GTAI), Germany is home to Europe’s largest pharmaceutical market, and the world’s fourth largest. In 2019, this market was valued at $41.4 billion, and was predicted to grow at an annual rate of 6% from 2020 to 2027, with some of the world’s largest pharmaceutical companies leading research, development and production in the country, including Boehringer Ingelheim, Bayer, and Pfizer.
According to Germany Trade and Invest (GTAI), Germany is home to Europe’s largest pharmaceutical market, and the world’s fourth largest. In 2019, this market was valued at $41.4 billion, and was predicted to grow at an annual rate of 6% from 2020 to 2027, with some of the world’s largest pharmaceutical companies leading research, development and production in the country,…

BV-2 shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity. BV-2 is widely used as an alternative model system for primary microglia and neurodegenerative disease model in vitro. The model is usually induced by Lipopolysaccharide (LPS) treatment.
BV-2 Cells Derivation and biomarker BV-2 is a type of microglial cell derived from C57/BL6 murine. The BV2 cells are immortalized by v-raf /v-myc carrying J2 retrovirus. BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level. BV2 microglia cell line retains microglia morphological and functional characteristics. In accordance with v-raf/v-myc expressed characters, the metabolic and proliferation rate of in…

A white paper shedding new light on the accelerated shift to digital engagement in Medical Affairs.
COVID-19 has had devastating effects on individuals, economies, and health systems around the world. If there is a pandemic silver lining, part of it may be that the disruption has created an opportunity for biopharmaceutical companies of all sizes to revisit how they engage with customers, including the chance to take a fresh look at how their Medical Affairs teams communicate with increasingly important stakeholders. While communication prefer- ences had already been shifting toward more digital platforms over the last several years, COVID amplified the dynamic, creating an urgency for biopharma manufacturers to quicken the pace of change.This paper sheds new light on several aspects of…

It’s estimated that almost 1 in 7 people experience mental health problems in the workplace. According to HSE, in 2019/20 there were an estimated 828,000 employees affected by work-related stress, depression, or anxiety, and this is only expected to rise as the long-lasting impacts of the COVID-19 pandemic continue to surface. In this article, we outline some of the key ways to look after your mental health at work, with tips for both employers and employees.
It’s estimated that almost 1 in 7 people experience mental health problems in the workplace. According to HSE, in 2019/20 there were an estimated 828,000 employees affected by work-related stress, depression, or anxiety, and this is only expected to rise as the long-lasting impacts of the COVID-19 pandemic continue to surface. In this…

A targeted email is one that’s sent to a defined segment of a mailing list and is more specific to the needs of those in the segment than an email that’s sent to an entire list. For recruiters in the pharma industry, targeted email campaigns can be a really great way of reaching the most relevant candidates and of developing your employer brand right at the heart of your target audience.
A targeted email is one that’s sent to a defined segment of a mailing list and is more specific to the needs of those in the segment than an email that’s sent to an entire list. For recruiters in the pharma industry, targeted email campaigns can be a really great way of reaching the most relevant candidates and of developing your employer brand right at the heart of your target audience. According to WordSt…