Articles

A brief introduction to human tumor cell lines. History, benefits and applications of human cancer cell lines.
Tumor cell lines (or cancer cell lines) are derived from the cancerous growths on an organ in a human or animal subject. These cell lines have undergone laboratory modifications that render them immortalized—they are capable of proliferating indefinitely in an in vitro environment. For that reason, tumor cell lines have become invaluable tools in the field of cancer research.   History of Human Cancer Cell Lines In the first half of the 20th century, various experiments demonstrated that animal cell lines could be maintained in an in vitro environment. The first human cell line was established in 1951, from cervical carcinoma cells taken from 30-year-old H…

According to Germany Trade and Invest (GTAI), Germany is home to Europe’s largest pharmaceutical market, and the world’s fourth largest. In 2019, this market was valued at $41.4 billion, and was predicted to grow at an annual rate of 6% from 2020 to 2027, with some of the world’s largest pharmaceutical companies leading research, development and production in the country, including Boehringer Ingelheim, Bayer, and Pfizer.
According to Germany Trade and Invest (GTAI), Germany is home to Europe’s largest pharmaceutical market, and the world’s fourth largest. In 2019, this market was valued at $41.4 billion, and was predicted to grow at an annual rate of 6% from 2020 to 2027, with some of the world’s largest pharmaceutical companies leading research, development and production in the country,…

BV-2 shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity. BV-2 is widely used as an alternative model system for primary microglia and neurodegenerative disease model in vitro. The model is usually induced by Lipopolysaccharide (LPS) treatment.
BV-2 Cells Derivation and biomarker BV-2 is a type of microglial cell derived from C57/BL6 murine. The BV2 cells are immortalized by v-raf /v-myc carrying J2 retrovirus. BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level. BV2 microglia cell line retains microglia morphological and functional characteristics. In accordance with v-raf/v-myc expressed characters, the metabolic and proliferation rate of in…

A white paper shedding new light on the accelerated shift to digital engagement in Medical Affairs.
COVID-19 has had devastating effects on individuals, economies, and health systems around the world. If there is a pandemic silver lining, part of it may be that the disruption has created an opportunity for biopharmaceutical companies of all sizes to revisit how they engage with customers, including the chance to take a fresh look at how their Medical Affairs teams communicate with increasingly important stakeholders. While communication prefer- ences had already been shifting toward more digital platforms over the last several years, COVID amplified the dynamic, creating an urgency for biopharma manufacturers to quicken the pace of change.This paper sheds new light on several aspects of…

It’s estimated that almost 1 in 7 people experience mental health problems in the workplace. According to HSE, in 2019/20 there were an estimated 828,000 employees affected by work-related stress, depression, or anxiety, and this is only expected to rise as the long-lasting impacts of the COVID-19 pandemic continue to surface. In this article, we outline some of the key ways to look after your mental health at work, with tips for both employers and employees.
It’s estimated that almost 1 in 7 people experience mental health problems in the workplace. According to HSE, in 2019/20 there were an estimated 828,000 employees affected by work-related stress, depression, or anxiety, and this is only expected to rise as the long-lasting impacts of the COVID-19 pandemic continue to surface. In this…

A targeted email is one that’s sent to a defined segment of a mailing list and is more specific to the needs of those in the segment than an email that’s sent to an entire list. For recruiters in the pharma industry, targeted email campaigns can be a really great way of reaching the most relevant candidates and of developing your employer brand right at the heart of your target audience.
A targeted email is one that’s sent to a defined segment of a mailing list and is more specific to the needs of those in the segment than an email that’s sent to an entire list. For recruiters in the pharma industry, targeted email campaigns can be a really great way of reaching the most relevant candidates and of developing your employer brand right at the heart of your target audience. According to WordSt…

ASAP Innovations diversifies its pipeline of niche PPE products for workers and advises on the importance of implementing a stricter selection process.
Organisations must stop applying a one-size-fits-all approach to PPE and ensure workers are provided with protection specially designed for an intended use. This is according to leading glove and face mask manufacturer, ASAP Innovations which says that it is imperative that distributors and purchasers understand the importance of tailoring PPE for specific industry needs. Providing suitable PPE has been at the epicentre of multiple news stories, with The Royal College of Nursing calling for an update on guidelines for suitable protective equipment. However, whilst PPE plays a major role in the healthcare industry, it is a…

The COVID pandemic has been the catalyst to change the way the pharmaceutical industry (Pharma) engages with HCPs. Partnering with large and small pharma alike, this whitepaper explores Amplity's flexible model tailored to each customer’s needs leveraging the benefits of remote and in-person promotion, optimizing the promotional mix across personal and non-personal channels, and ultimately providing relevant, timely, and credible information to HCPs.
COVID-19 has had a profound impact on the commercialization of pharmaceuticals in the United States. Health Care Provider (HCP) information-seeking needs and preferences have changed dramatically in response to the outbreak, as have the options for pharmaceutical manufacturers to meet these new needs and preferences. Indeed, in a curious twist…

In this article, we outline ten of the top pharmaceutical companies in the world, including Roche, Johnson and Johnson and Pfizer.
In this article, we outline ten of the top pharmaceutical companies in the world… Roche Founded in Switzerland in 1896, Roche has been a pioneer in healthcare for almost 125 years. The company discovers innovative pharmaceuticals and diagnostics to help millions of patients globally, and is the global leader in cancer treatments; with medicines treating breast, skin, colon, lung, and numerous other cancers. Roche also offers a diverse portfolio of biopharmaceuticals, with 17 currently on the market. The company has over 90,000 employees working across more than 100 countries, and group sales at the end of 2020 reached over $63 billion, with Roche’s pharmaceutica…

Online interviewing platforms are becoming more important in 2023 than ever before, and pharma companies including Novo Nordisk, Novartis and Takeda are already making the most of them. In this article, we outline 17 online interviewing platforms for both on-demand applicant screening and live interviewing for you to consider, drawing on the unique features each has to offer.
Online interviewing platforms are becoming more important in 2023 than ever before, and pharma companies including Novo Nordisk, Novartis and Takeda are already making the most of them. In this article, we outline 16 online interviewing platforms for both on-demand applicant screening and live interviewing for you to consider, drawing on the unique features each has to offer… Retorio Retorio is an AI video interviewing…

Penn State academics are using SR-Tek transparent pressure vessels to determine optimum production conditions for biopharmaceuticals in a bid to increase yields and prevent contamination events.
Biopharmaceuticals, or biologically produced medications, are rapidly being used to treat a host of chronic and genetic conditions. Expected to be worth $535 billion by 2027, the biopharmaceutical market is currently undergoing significant growth. However, production issues are hampering the industry’s ability to meet demand. Now a research team from Pennsylvania State University is looking to tackle one of the major bottlenecks in biopharmaceutical production – purification and filtration. Led by Dr Andrew Zydney, 14 graduate students from the university are investigating system effects, including…

Australia is home to a multi-billion-dollar pharmaceutical market that has been growing continuously over the past decade especially. Here are ten of the top pharmaceutical companies in the country as of 2021.
Australia is home to a multi-billion-dollar pharmaceutical market that has been growing continuously over the past decade especially. Here are ten of the top pharmaceutical companies in the country as of 2021… Pfizer Pfizer has manufacturing sites in Sydney, Melbourne, Perth and Adelaide, and its products are used in hospitals and pharmacies across the country. Pfizer Australia offers a portfolio containing some of the world’s best-known prescription medicines, vaccines, and OTC products. Roche Roche is dedicated to improving the health and wellbeing of people in Australia and has had…

All drugs have side effects and can be poisonous if used in in too large doses. Pharmacovigilance is a set of legally required activities performed by the pharmaceutical companies to ensure their drug has an acceptable benefit-risk profile. The adverse drug reactions can lead to hospitalization and even to death in worst cases. We list here how drugs could be made safer and how the number of deaths and hospitalization caused by drugs could be reduced. There are other ways to do it, and the actions presented here might not be the best ways in all countries, but we have explained our choices and we would be happy to hear alternative opinions from other people, authorities, and companies.
What is pharmacovigilance? The goal of pharmacovigilance is to make drugs safer by monitoring the benefit…

With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items.
With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items. However, the real advantage of 3D printing technology lies in its printing materials. Only by developing more new materials can the application fields of 3D printing technology be expanded. At present, 3D printing materials mainly include engineering plastics, photosensitive resins, rubber materials, metal materials, and ceramic materials. In addition, food materials such as colored plaster materials, artificial bone meal, cellular biological materials, and sugar can also be used in the field of 3D printing. What kind of polymer materials can be used in 3D Printing? Engineering plasti…

Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions.
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions. Except for insoluble coating materials or broken capsule shells, all solid preparations should pass through the screen. Therefore, a disintegration test should be carried out to make sure that a drug is rele…

We often associate the term ‘user experience’ (UX) with technology and, more specifically, software. However, to ignore its role in the physical world is to limit the potential of product design in improving safety, efficiency and cost-effectiveness.
Delivering exceptional UX means putting the user at the centre of design and incorporating the input of designers, stakeholders, experts and users themselves at every stage of the process. In pharma, this ‘user’ is the patient.  It isn’t as simple as developing products that patients enjoy using, though. Truly user-centred pharmaceutical products mitigate all patient challenges, including safety and security and adherence.  Built alongside patie…

10 pharmaceutical events taking place in August 2021, including: 2nd Gene Therapy Immunogenicity Summit, 14th International Conference on Pharmaceutics and Drug Safety, 34th World Congress on Pharmacology, Prostate Cancer Drug Development Summit and 6th CAR-TCR Summit.
10 pharmaceutical events taking place in August 2021: 2nd Gene Therapy Immunogenicity Summit (August 3rd-5th) The 2nd Gene Therapy Immunogenicity Summit is the industry’s definitive forum enabling you to better modulate, measure and predict immune response to your gene therapy candidate. 14th International Conference on Pharmaceutics and Drug Safety (August 6th-7th) This conference brings together professional groups of scientists and researchers from all over the world to present and exchange advanced ideas related to drug s…

There are two types of enzymes produced by biological cells: one type of enzymes that are produced inside the cell and then secreted outside the cell for action, called extracellular enzymes. Most of these enzymes are hydrolases. For example, the two amylases used in enzymatic production of glucose are secreted by Bacillus subtilis and root enzymes during fermentation. Such enzymes are generally high in content and easy to obtain.
There are two types of enzymes produced by biological cells: one type of enzymes that are produced inside the cell and then secreted outside the cell for action, called extracellular enzymes. Most of these enzymes are hydrolases. For example, the two amylases used in enzymatic production of glucose are secreted by Bacillus subtilis and root enzymes during fermenta…

The factors that affect enzyme catalysis (that is, enzyme activity) will definitely affect the rate of enzymatic reactions, but the factors that affect the rate of enzymatic reactions do not necessarily affect the catalysis. pH, temperature, ultraviolet light, heavy metal salts, inhibitors, activators, etc. will affect the catalysis and the rate of enzymatic reactions. The concentration of the enzyme, the concentration of the substrate, etc. will not affect the enzyme catalysis, but can affect the rate of the enzymatic reaction.
The factors that affect enzyme catalysis (that is, enzyme activity) will definitely affect the rate of enzymatic reactions, but the factors that affect the rate of enzymatic reactions do not necessarily affect the catalysis. pH, temperature, ultraviolet light, heav…

Whilst a remote pharma job may have the same job description as an in-office role, these are two very different working environments, and so the things you look for when interviewing candidates may differ. In this article, we outline some of the most important qualities a remote employee should have, along with some interview questions for you to ask to assess each one.
Whilst a remote pharma job may have the same job description as an in-office role, these are two very different working environments, and so the things you look for when interviewing candidates may differ. In this article, we outline some of the most important qualities a remote employee should have, along with some interview questions for you to ask to assess each one… Reliability You need to be able to trust remote employe…