Articles

In the competitive Life Sciences job market, standing out as a recruitment agency can be tough. In this article, we outline 8 things you can do to make your name known in the industry, and to help you continue to attract the best talent for your clients and develop long-lasting relationships with employers across the Life Sciences field.
In the competitive Life Sciences job market, standing out as a recruitment agency can be tough. In this article, we outline 8 things you can do to make your name known in the industry, and to help you continue to attract the best talent for your clients and develop long-lasting relationships with employers across the Life Sciences field. Immerse Yourself in the Industry To stand out as a Life Sciences recruitment agency, you’ll need to be aware of the chall…

Annotating CRFs (Case Report Forms) is an important, but almighty task. You need to manually create annotations for every single form. Then convert your forms into PDF. That’s a lot of time and resources. But you don’t need to do it the hard way… Read the article "Why switch to automated CRF annotations?" to find out how!
What’s the deal with annotated CRFs? To put it simply, annotated CRFs document the location in a database of the data collected for each question on a form. Or put another way, it’s a mapping between each item on a form to its corresponding variable contained within the corresponding dataset. Annotated CRFs are part of the mandatory CDISC submission deliverables to the FDA. So they’re a MUST! They provide traceability. They help FDA reviewers find the origin of v…

No sooner than medical device manufacturers have completed their MDR compliance project, they must prepare to adapt products, labelling and artwork to comply with upcoming IVDR counterpart legislation. Bob Tilling, VP Global Sales at Kallik, reveals the top compliance challenges manufacturers must address and how digital solutions are now set to play a leading regulatory role.
The EU’s In Vitro Diagnostic Regulation is set to be implemented in May 2022, but for many in vitro medical device manufacturers, the follow-on UDI implementation deadlines – Class D in 2023, Class C and B in 2025, and Class A in 2027 – will have greater repercussions. Over 80% of devices not requiring certification under the previous IVDD (In Vitro Diagnostic Directive) will now require IVDR certification, affecting…

They may have been developed to better manage fluids on production lines, but transparent pressure vessels are increasingly being seen as ideal testing environments for research and development. With orders from blue chip companies including Apple research organisations like Boston Scientific and major universities, engineer Loris Medart from SR-TEK discusses how vessels designed for use in industry are revolutionising R&D.
Fluids have long been seen as one of the most difficult substances to manage on a production line. Movement, pressure, temperature, and humidity are just a few of the factors that can drastically alter fluid performance. As a result, when creating the world’s only commercially available transparent pressure vessel we had to ensure it enabled complete control of the inter…

How do CDISC standards fit into the drug development process? Find out which are the CDISC data standards required for regulatory submission and when to use them!
Introduction The clinical trial process is a long, expensive, complicated one that often ends in failure. This means that to have a successful outcome, careful decision making and planning are absolutely essential. And so are data standards! The FDA requires clinical study data to be submitted in a standardized format. This allows the FDA to receive, process, review and archive submissions efficiently. It also lets them explore research options by putting together data from multiple studies. As part of a collaboration with the FDA, CDISC developed data standards to be used from study design and data collection through to analysis.…

Over the past 3 years, employees working across the Life Sciences have proven that there is space for both hybrid and fully remote working within the industry. Although these ways of working bring many benefits to the industry, they can also have their drawbacks. If you’re planning on making remote working a more permanent choice for employees, there are some extra things to consider, especially in terms of how you’re going to keep your employees connected.
Over the past 3 years, employees working across the Life Sciences have proven that there is space for both hybrid and fully remote working within the industry. Although these ways of working bring many benefits to the industry, they can also have their drawbacks. If you’re planning on making remote working a more permanent choice for emp…

Leukemia cell lines are important and widely used research tools. Their usefulness is mainly connected with their ability to provide an indefinite source of biological material for experimental purposes. Due to their high relevance for human disease, easy manipulation, and relative low costs, leukemia cell lines continue to represent vital in vitro model systems for a large range of ongoing investigations, especially basic leukemia research and drug discovery.
Leukemia cell lines are important and widely used research tools. Their usefulness is mainly connected with their ability to provide an indefinite source of biological material for experimental purposes. Due to their high relevance for human disease, easy manipulation, and relative low costs, leukemia cell lines continu…

The SH-SY5Y cell line is in the widespread use in experimental neurological studies, including the analysis of neuronal differentiation, metabolism, functions related to neurodegenerative and neuroadaptive processes, neurotoxicity, and neuroprotection.
Background SH-SY5Y cells, the subline of the parental line SK-N-SH cells, are originally established from a bone marrow biopsy of a neuroblastoma patient with sympathetic adrenergic ganglial origin. SK-N-SH were subcloned three times: first to SH-SY, and then to SH-SY5, finally to SH-SY5Y. SH-SY5Y were deposited to the ATCC® in 1970 by June L. Biedler. Once the primary mammalian neurons derived from embryonic central nervous system tissue terminally differentiate into mature neurons, the cells can be no longer propagated. While…

When attending your next pharma job interview, remember that interviewers aren’t only assessing you during the interview, but also throughout the entire process. How you act after your job interview – regardless of whether it’s your first, second or final round – can have a big impact on the impression you make on interviewers. In this article, we outline 11 things you can do after your next pharma job interview to prove your strength as a candidate.
When attending your next pharma job interview, remember that interviewers aren’t only assessing you during the interview, but also throughout the entire process. How you act after your job interview – regardless of whether it’s your first, second or final round – can have a big impact on the impression you make on interviewers. In this article,…

According to LinkedIn, around 60% of job seekers use job boards to search for new roles, making it one of the biggest channels for job hunting. Although job boards provide a great opportunity for you to push your roles to candidates outside of your organisation’s network and to engage large volumes of candidates across multiple platforms, larger boards aren’t always the best way to attract high-quality candidates. This is where niche job boards come in…
According to LinkedIn, around 60% of job seekers use job boards to search for new roles, making it one of the biggest channels for job hunting. Although job boards provide a great opportunity for you to push your roles to candidates outside of your organisation’s network and to engage large volumes of candidates across multiple platforms, la…

13 pharmaceutical events taking place in September 2021, including: Euro-Global Conference on Biotechnology and Bioengineering (September 6th-8th), 4th Edition of Global Conference on Pharmaceutics and Novel Drug Delivery Systems (September 6th-8th), 2nd Operationalize: Decentralized Clinical Trials Summit (September 7th-9th) and more.
13 pharmaceutical events taking place in September 2021: Euro-Global Conference on Biotechnology and Bioengineering (September 6th-8th) The theme of this conference is ‘Addressing Current Challenges in Biotechnology and Bioengineering.’ ECBB 2021 will consist of keynote lectures, oral & poster presentations, workshops, and seminars from experts and young scholars in the field of Biotechnology and Bioengineering. 4th Edition of Global Conference on Pharmac…

Human primary cardiomyocyte-based models are superior to whether artificial cellular models or animal models due to their native physiological and pharmacological properties. Therefore, human primary cardiomyocytes have the potential to become the most clinically relevant model for developing novel cardiac drugs and predicting safety assessment of new drugs.
What are Human Cardiomyocytes? The heart is one of the first organs formed in the embryo, which highlights its crucial function in pumping blood to carry oxygen and nutrients to other tissues of the organism whether during development or in later life. Human primordial heart starts to beat at around 22 days after fertilization. It is the presence of cardiomyocytes that results in the early beating of the heart. Cardiomyocytes,…

Animal primary cells are isolated directly from healthy or diseased tissue via an enzymatic, chemical, or mechanical process. These cells can be taken from the animal’s kidney, liver, skin, or another organ. Once removed from the in vivo environment, these cells are then placed in an artificial (in vitro) environment for propagation.
Animal Primary Cells Animal primary cells are isolated directly from healthy or diseased tissue via an enzymatic, chemical, or mechanical process. These cells can be taken from the animal’s kidney, liver, skin, or another organ. Once removed from the in vivo environment, these cells are then placed in an artificial (in vitro) environment for propagation.   When in an in vitro environment, animal cells must be carefully cultured. This includes ensu…

Stem cells are primitive, undifferentiated cells that can potentially turn into a wide variety of cell types. Liver cells, blood cells, and muscle cells are only a few of the specialized types that have their origin in stem cells. Aside from their ability to differentiate into cells with specific functions, they can also divide or renew themselves indefinitely.
Stem cells are primitive, undifferentiated cells that can potentially turn into a wide variety of cell types. Liver cells, blood cells, and muscle cells are only a few of the specialized types that have their origin in stem cells. Aside from their ability to differentiate into cells with specific functions, they can also divide or renew themselves indefinitely.     Because they can repair and regenerate damaged tissue…

BM-MNCs, the heterogeneous cell mixture, are widely used in cell-based therapy and regenerative medicine, which can promote distinct angiogenic properties, mediate vascular repair, express several cytoprotective growth factors and cytokines and restore pathologically altered genes after ischemic injury. BM-MNCs can be prepared rapidly within a few hours and be collected autologously just prior to administration, which could be advantageous in acute clinical care settings, compared with other cell sources, such as stem cells requiring a period of cell culture before transplantation.
Cell therapy has been identified as an effective method to regenerate damaged tissue. Bone marrow-derived mononuclear cells (BM-MNCs) were first reported on a therapeutic angiogenesis for…

The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value.
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value. However, there are some technical difficulties that hinder the development of children's oral liquid preparations. Poor solubil…

Pharmaceutical organisations in China are increasingly looking abroad for new markets, boosted by their Government’s strong support for businesses that invest overseas. The country is now the world’s second-largest pharma market, behind only the US, and produces around 40 per cent of the world’s active pharmaceutical ingredients.
Pharmaceutical organisations in China are increasingly looking abroad for new markets, boosted by their Government’s strong support for businesses that invest overseas. The country is now the world’s second-largest pharma market, behind only the US, and produces around 40 per cent of the world’s active pharmaceutical ingredients. And with the domestic market also moving from traditional generic medicines to more innovative therapies, Chinese pharma firms are keen t…

As you can’t predict exactly how a job interview will go, it’s important to be fully prepared beforehand to help you stay confident, calm, and collected. Being well prepared will also help you make a great first impression on your interviewer, as it will be very clear to them how much time you’ve put into your preparation, and how much you really care about the role.
As you can’t predict exactly how a job interview will go, it’s important to be fully prepared beforehand to help you stay confident, calm, and collected. Being well prepared will also help you make a great first impression on your interviewer, as it will be very clear to them how much time you’ve put into your preparation, and how much you really care about the role. In this article, we outline 10 things you can do before your…

During the Covid pandemic, digital has transformed everything from patient engagement and recruitment to continuous health monitoring and remote treatment. Kathleen O’Brien of Amplexor Life Sciences reflects on the challenges and considerations.
Process digitalisation is one positive development that has emerged from the Covid pandemic. Reliance on digital channels for conducting consultations, managing treatments and measuring outcomes has allowed many services to continue almost unhindered and the way has been paved for a more digital future. Life sciences companies must now lean into the trend and make the most of the bigger part that remote care and monitoring will play in ongoing treatment models. The FDA’s Digital Health Center of Excellence in the US sets out many of the opportunitie…

With the increasing supply of good quality fresh and cryo-preserved human hepatocytes (such as ABC-TC3646, AcceGen advanced technology), researchers can further apply this in vitro model to advance our knowledge of liver functions, the mechanisms underlying the regulation and drug-induced changes of metabolic enzyme expression and hepatocellular integrity.
Hepatocytes are parenchymal cells that constitute as much as 80% of the total liver volume and mediate a number of vital liver functions, such as the control of lipid and carbohydrate homeostasis, the synthesis of various proteins, the storage of vitamins, the processing of bile, immunological defense, and the biotransformation of endogenous molecules and xenobiotics [1]. Human hepatocytes directly reflect the specific metabolism and func…