Biotech - Articles

The proteome is the sequence identification and content analysis of all proteins in a living organism, but the information of PTM (post-translational modification) cannot be ignored. Phosphorylation proteins account for about 1/3 of all proteins in organisms, so phosphorylation has become one of the types of protein PTMs that has received the most attention.
The proteome is the sequence identification and content analysis of all proteins in a living organism, but the information of PTM (post-translational modification) cannot be ignored. Phosphorylation proteins account for about 1/3 of all proteins in organisms, so phosphorylation has become one of the types of protein PTMs that has received the most attention.   Common phosphorylated protein identification methods Western-blot The pr…

Whole genome sequencing looks at the whole genome of an organism, while targeted region sequencing looks at only the parts that are of interest. Targeted genome sequencing is a very sensitive and specific way to find SNPs, indels, CNVs, and large SVs.
What is targeted region sequencing? Whole genome sequencing looks at the whole genome of an organism, while targeted region sequencing looks at only the parts that are of interest. Targeted genome sequencing is a very sensitive and specific way to find SNPs, indels, CNVs, and large SVs. Compared to whole genome sequencing, targeted genome sequencing is more focused, economical, and effective. Furthermore, targeted regions can be sequenced at a much greater depth for a lower cost, which contributes to detecting rare variations. Whole exome seq…

As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases.
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases. The human genome contains approximately 3 billion base pairs of DNA. Among them, only about 30 million base pairs of DNA carry the information for protein synthesis. This part of the genome is…

Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics research. At the moment, Illumina, Ion Torrent/Life Technologies, 454/Roche, Pacific Bioscience, Nanopore, and GenapSys are all NGS platforms that can be used. They can produce reads of 100–10,000 bp in length, enabling sufficient coverage of the genome at a lower cost. But faced with the enormous amount of sequence data, how do we best deal with it? And what are the most appropriate computational methods and analysis tools for this purpose? In this review, we focus on the bioinformatics pipeline of whole exome sequencing (WES).
Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics resear…

In competition with bacteriophages, bacteria and archaea have evolved unique ways of defending, which include the CRISPR/Cas systems and the immune systems of bacteria and archaea, which resist the invasion of foreign DNA or RNA and recognize the foreign invaders and cleave them for immune defense.
In competition with bacteriophages, bacteria and archaea have evolved unique ways of defending, which include the CRISPR/Cas systems and the immune systems of bacteria and archaea, which resist the invasion of foreign DNA or RNA and recognize the foreign invaders and cleave them for immune defense.   CRISPR/Cas systems are now useful research tools that are easy to use and work well in the field of genetic engineering. In a CRISPR/Cas9-induced gene editing process, for example, the Cas9 enzy…

Decentralization allows for more diverse patient participation and improved data collection, leading to faster, more accurate results in clinical trials.
With the emergence of COVID-19, the Decentralization of Clinical Trials became necessary to comply with social distancing requirements while carrying out clinical research. Over the past few years, the clinical trial landscape has shifted its focus to patient-centric practices to promote patient engagement. But now as the pandemic is long gone, it is time to reflect on how DCT studies are genuinely addressing long-standing issues in research and development for sponsors, study teams, and of course, the patients! The digital shift in clinical trials has brought about the potential to improve both patient experience and clinical data qualit…

In this blog post, we will find out how electronic clinical outcome assessments are helping the clinical trials industry handle the ever-growing list of patient data and, at the same time, reduce patient burden!
With the rising demand for improving patient safety in clinical trials, the adoption of patient-centric solutions is considered the best route to enhance data accuracy and experience automated workflows. This is where eCOA comes into play. In this blog post, we will find out how electronic clinical outcome assessments are helping the clinical trials industry handle the ever-growing list of patient data and, at the same time, reduce patient burden! What is eCOA? Electronic clinical outcome assessment (eCOA) refers to the process of leveraging technology to better capture data and enh…

Electroplating intermediate is an additive material for electroplating modification in terms of grain size, gloss, thickness, and plating speed.
Electroplating intermediates refer to a class of fine chemicals used as electroplating additives. Unlike the salt used in the plating production process, the electroplating intermediate is an additive material for electroplating modification in terms of grain size, gloss, thickness, and plating speed. How Can Electroplating Intermediates be Classified? According to the different plating types, electroplating intermediates can be divided into nickel plating intermediates, copper plating intermediates, tin plating intermediates, gold plating intermediates, silver plating intermediates, etc. Meanwhile, according to different functions, electropla…

The biotech industry is a large and growing field with many opportunities for those who want to pursue it professionally. The growth of this industry has been rapid in recent years, with more than 200 new products being marketed every year. In this article, we will look at the current trends in the industry and discuss how they affect marketers and consumers.
What is Biotechnology? Biotechnology is the application of biological processes and materials, including biochemistry, microbiology and molecular biology. Nobel-prize-winning chemist George Wald coined the term in 1949. Biotechnology is not the same as traditional biochemistry: it encompasses a diverse range of techniques we can use for industrial processing and research purposes. For example, it includes processes such as recombin…

There are both large and small ADC molecules. A variety of biological analysis methods and platforms are needed to analyze the diversity of ADCs. Conventional LC-MS/MS small-molecule assays are often used to analyze uncoupled payloads and DAR distributions over time, while ligand binding assays (LBA) and LC-MS/MS can also be used to analyze total antibodies (TAb) and total ADCs. The choice of analysis platform depends on the availability of key reagents, the required analytical sensitivity, and the different problems that need to be addressed at various stages of drug development. In this article, the classical LBA and LC-MS/MS methods for quantitative analysis of ADC components are briefly introduced.
Ligand binding assay (LBA) LBA is the gold standard for macromolecular bioanalysis. LB…

Probiotics are a type of active microorganisms that play a role by improving the balance of the host's intestinal microflora. They can produce definite health effects to improve the host's microecological balance and play a beneficial role. In 2001, the World Food and Agriculture Organization (FAO) and the World Health Organization (WHO) also defined probiotics as follows: Live bacteria that can play an effective role in the health of consumers by ingesting an appropriate amount. Bacteria or fungi in humans and animals mainly include: Clostridium butyricum, Lactobacillus, Bifidobacterium, Lactobacillus acidophilus, Actinomycetes, Yeasts, etc.
Probiotics are a type of active microorganisms that play a role by improving the balance of the host's intestinal microflora. They can produce definit…

Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively.
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively.   After the 1950s, the application of serum enzyme activity measurement as an indicator fo…

Whole genome sequencing (WGS) has the capacity to greatly enhance genomic knowledge and understand mysteries of life by utilizing the most advanced genetic sequencing technologies. WGS can be used for variant calling, genome annotation, phylogenetic analysis, reference genome construction, and more. WGS tries to cover the whole genome, but actually covers 95% of the genome with technical difficulties in sequencing regions such as centromeres and telomeres. Another challenge for WGS is data management. As larger datasets become more accessible and affordable, computational analysis will be the rate-limiting factor rather than sequencing technology. Here we will discuss the bioinformatics workflow for detection of genetic variations in WGS to help you get through it.
Whole genome sequencing (…

Carbon nanomaterials have been speedily developed due to their unique electronic, optical, thermal, mechanical, and chemical nature.
History of Development As early as 1985, the discovery of fullerene with the “football” structure immediately attracted the world’s attention. Then, carbon nanotubes with a hollow cylindrical structure are formed based on mild modifications toward fullerenes. In 1991, Japanese researchers discovered carbon nanotubes in carbon fibers for the first time. In 2004, researchers discovered the 2D planar nanomaterial whose planar thickness is confined to the nanoscale range. At the same time, researchers also developed a practical “scotch tape” technique to separate single-layer graphene from bulk graphene. Buckyballs (fullerenes), carbon nanotubes, and graphene all…

The biotech industry is a large and growing field with many opportunities for those who want to pursue it professionally. The growth of this industry has been rapid in recent years, with more than 200 new products being marketed every year. In this article, we will look at the current trends in the industry and discuss how they affect marketers and consumers.
What is Biotechnology? Biotechnology is the application of biological processes and materials, including biochemistry, microbiology and molecular biology. Nobel-prize-winning chemist George Wald coined the term in 1949. Biotechnology is not the same as traditional biochemistry: it encompasses a diverse range of techniques we can use for industrial processing and research purposes. For example, it includes processes such as recombin…

Lung cancer is a major type of cancer in the world, with the highest morbidity and mortality among all malignant tumors. ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases.
Lung cancer is a major type of cancer in the world, with the highest morbidity and mortality among all malignant tumors. ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases. Statistics show that about 55% of ALK-positive advanced NSCLC patients will develop brain metastases during the treatment process, which is a serious challenge facing oncologists. In recent years, the application of targe…

Protein identification here refers to the accurate screening and identification of proteins using certain biochemical and physical methods. Traditional protein identification methods, including immunoblotting, comigration analysis of known or unknown proteins, and chemical sequencing of endopeptides, are complicated, time-consuming, and less accurate.
Methods in protein identification Protein identification here refers to the accurate screening and identification of proteins using certain biochemical and physical methods. Traditional protein identification methods, including immunoblotting, comigration analysis of known or unknown proteins, and chemical sequencing of endopeptides, are complicated, time-consuming, and less accurate.   Protein identification methods have evolved fro…

16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms.
16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms. 16S/18S/ITS amplicon sequencing reveals the species of microorganisms in environmental samples and their differences, relative abundance, population structure and evolutionary relationships. It plays an important role in the research of microorganisms and human health, agriculture and animal husbandry, environmental detection and t…

16S/18S/ITS amplification sequencing uses the next/third generation sequencing platform and performs high throughput sequencing of PCR products from specific regions such as 16S rDNA/18S rDNA/ITS/ functional genes. It overcomes the disadvantage of some microorganisms that is difficult or impossible to culture, and obtains the information of microbial community structure, evolutionary relationships and microbial correlation with environment in environmental samples.
16S/18S/ITS amplification sequencing uses the next/third generation sequencing platform and performs high throughput sequencing of PCR products from specific regions such as 16S rDNA/18S rDNA/ITS/ functional genes. It overcomes the disadvantage of some microorganisms that is difficult or impossible to culture, and obtains the inf…

Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. Sequencing the entire microbial genome is important for construction of accurate reference genomes, microbial identification, and other comparative genomic studies.
Microorganisms widely exist in nature and are closely related to human life and production. They are generally divided into fungi, actinomycetes, bacteria, spirulina, rickettsia, chlamydia, mycoplasma and viruses. Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. Sequencing the entire microbial genome is important f…